Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid

Youhong Hu; Emmanuelle J. Meuillet; Lixin Qiao; Margaret M. Berggren; Garth Powis; Alan P. Kozikowski

doi:10.1016/S0040-4039(00)01186-2

Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid

Youhong Hu, Emmanuelle J. Meuillet, Lixin Qiao, Margaret M. Berggren, Garth Powis, Alan P. Kozikowski

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

1D-3,4-Dideoxyphosphatidylinositol ether lipid 2, a PI analog, was synthesized through a sequence of protection/deprotection protocols and two Barton deoxygenation reactions, starting from L-(-)-quebrachitol. DDPIEL is 18-fold more potent than its monodeoxy counterpart DPIEL in the inhibition of PI3-K.

Original language	English (US)
Pages (from-to)	7415-7418
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	39
DOIs	https://doi.org/10.1016/S0040-4039(00)01186-2
State	Published - Sep 23 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)01186-2

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title = "Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid",

abstract = "1D-3,4-Dideoxyphosphatidylinositol ether lipid 2, a PI analog, was synthesized through a sequence of protection/deprotection protocols and two Barton deoxygenation reactions, starting from L-(-)-quebrachitol. DDPIEL is 18-fold more potent than its monodeoxy counterpart DPIEL in the inhibition of PI3-K.",

author = "Youhong Hu and Meuillet, {Emmanuelle J.} and Lixin Qiao and Berggren, {Margaret M.} and Garth Powis and Kozikowski, {Alan P.}",

note = "Funding Information: This work was supported by the National Institutes of Health (Grant No. CA61015) and the Department of Defense (DAMD 17-93-V-3018). ",

year = "2000",

month = sep,

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doi = "10.1016/S0040-4039(00)01186-2",

language = "English (US)",

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T1 - Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid

AU - Hu, Youhong

AU - Meuillet, Emmanuelle J.

AU - Qiao, Lixin

AU - Berggren, Margaret M.

AU - Powis, Garth

AU - Kozikowski, Alan P.

N1 - Funding Information: This work was supported by the National Institutes of Health (Grant No. CA61015) and the Department of Defense (DAMD 17-93-V-3018).

PY - 2000/9/23

Y1 - 2000/9/23

N2 - 1D-3,4-Dideoxyphosphatidylinositol ether lipid 2, a PI analog, was synthesized through a sequence of protection/deprotection protocols and two Barton deoxygenation reactions, starting from L-(-)-quebrachitol. DDPIEL is 18-fold more potent than its monodeoxy counterpart DPIEL in the inhibition of PI3-K.

AB - 1D-3,4-Dideoxyphosphatidylinositol ether lipid 2, a PI analog, was synthesized through a sequence of protection/deprotection protocols and two Barton deoxygenation reactions, starting from L-(-)-quebrachitol. DDPIEL is 18-fold more potent than its monodeoxy counterpart DPIEL in the inhibition of PI3-K.

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U2 - 10.1016/S0040-4039(00)01186-2

DO - 10.1016/S0040-4039(00)01186-2

M3 - Article

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SN - 0040-4039

VL - 41

SP - 7415

EP - 7418

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 39

ER -

Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid

Abstract

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