Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; β-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of the Chemical Society, Chemical Communications|
|State||Published - Dec 1 1995|
ASJC Scopus subject areas
- Molecular Medicine