Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A

Alan P. Kozikowski, Giuseppe Campiani, Ashima Saxena, Bhupendra P. Doctor

Research output: Contribution to journalArticle

Abstract

Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; β-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.

Original languageEnglish (US)
Pages (from-to)283-285
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

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Pyrimidinones
Cholinesterase Inhibitors
Lactones
Acetylcholinesterase
Thermodynamic properties
Hot Temperature
Serum
huperzine A

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A. / Kozikowski, Alan P.; Campiani, Giuseppe; Saxena, Ashima; Doctor, Bhupendra P.

In: Journal of the Chemical Society, Chemical Communications, No. 2, 1995, p. 283-285.

Research output: Contribution to journalArticle

Kozikowski, Alan P. ; Campiani, Giuseppe ; Saxena, Ashima ; Doctor, Bhupendra P. / Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A. In: Journal of the Chemical Society, Chemical Communications. 1995 ; No. 2. pp. 283-285.
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