Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A

Alan P. Kozikowski, Giuseppe Campiani, Ashima Saxena, Bhupendra P. Doctor

Research output: Contribution to journalArticlepeer-review

Abstract

Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; β-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.

Original languageEnglish (US)
Pages (from-to)283-285
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number2
DOIs
StatePublished - Dec 1 1995

ASJC Scopus subject areas

  • Molecular Medicine

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