Syntheses of 18F‐labeled reduced haloperidol and 11C‐labeled reduced 3‐N‐methylspiperone

Hayden T. Ravert, Robert F. Dannals, Alan A. Wilson, Dean F. Wong, Henry N. Wagner

Research output: Contribution to journalComment/debate

Abstract

18F‐Labeled reduced haloperidol and 11C‐labeled reduced 3‐N‐methylspiperone were synthesized in a convenient and quantitative one step reduction from 18F‐labeled haloperidol and 11C‐labeled N‐methylspiperone, respectively. Both products were purified by semipreparative HPLC and were obtained at high specific activity and radiochemical purity.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume29
Issue number3
DOIs
StatePublished - Mar 1991

Keywords

  • Reduced haloperidol
  • carbon‐11
  • fluorine‐18
  • positron emission tomography
  • reduced methyl‐spiperone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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