SYNTAX Score and Long-Term Outcomes: The BARI-2D Trial

Fumiaki Ikeno, Maria Mori Brooks, Kaori Nakagawa, Min Kyu Kim, Hideaki Kaneda, Yoshiaki Mitsutake, Helen A. Vlachos, Leonard Schwartz, Robert L. Frye, Sheryl F. Kelsey, Katsuhisa Waseda, Mark A. Hlatky, Katherine M. Detre, Sheryl F. Kelsey, Maria Mori Brooks, Trevor J. Orchard, Stephen B. Thomas, Kim Sutton Tyrrell, Jamal S. Rana, Frani AverbachJoan M. MacGregor, Scott M. O'Neal, Kathleen Pitluga, Veronica Sansing, Mary Tranchine, Sharon W. Crow, Marianne (Marnie) Bertolet, Regina Hardison, Kevin Kip, Manuel Lombardero, Jiang Lu, Sue Janiszewski, Darina Protivnak, Sarah Reiser, Stephen Barton, Ping Guo, Yulia Kushner, Owen Michael, Jeffrey P. Martin, Christopher Kania, Michael Kania, Jeffrey O'Donnell, Rae Ann Maxwell, Robert L. Frye, Suzanne Goldberg, Yves Rosenberg, Patrice Desvigne-Nickens, Abby Ershow, David Gordon, Dina Paltoo, Teresa L Z Jones, Whady Hueb, José Ramires, Neuza Lopes, Bernardo Léo Wajchenberg, Eulogio E. Martinez, Sergio A. Oliveira, Expedito E. Ribeiro, Marcos Perin, Roberto Betti, Leonard Schwartz, George Steiner, Alan Barolet, Yolanda Groenewoud, Lisa Mighton, Kathy Camelon, Robert O'Rourke, Janet Blodgett, Edward Sako, Judith Nicastro, Robin Prescott, Charanjit Rihal, Frank Kennedy, Gregory Barsness, Amanda Basu, Alfredo Clavell, Robert Frye, David R. Holmes, Amir Lerman, Charles Mullaney, Guy Reeder, Robert Rizza, Hartzell Schaff, Steven Smith, Virend Somers, Thoralf Sundt, Henry Ting, R. Scott Wright, Pam Helgemoe, Diane Lesmeister, Deborah Rolbiecki, Luis Lepe-Montoya, Jorge Escobedo, Rafael Barraza, Rubén Baleón, Arturo Campos, Paula García, Carlos Lezama, Carlos Miramontes, Salvador Ocampo, Joaquín V. Peñafiel, Aquiles Valdespino, Raúl Verdín, Héctor Albarrán, Fernando Ayala, Eduardo Chávez, Héctor Murillo, Luisa Virginia Buitrón, Beatriz Rico-Verdin, Fabiola Angulo, Dale Adler, Austin Arthur Halle, Faramarz Ismail-Beigi, Suvinay Paranjape, Stacey Mazzurco, Karen Ridley, Kodangudi Ramanathan, Solomon Solomon, Barry Wall, Darryl Weinman, Tammy Touchstone, Lillie Douglas, Martial Bourassa, Jean Claude Tardif, Jean Louis Chiasson, Marc Andre Lavoie, Rémi Rabasa-Lhoret, Hélène Langelier, Suzy Foucher, Johanne Trudel, Scott Monrad, Vankeepuram Srinivas, Joel Zonszein, Jill Crandall, Helena Duffy, Eugen Vartolomei, Spencer King, Carl Jacobs, David Robertson, Marty Porter, Melanie Eley, Emmalee Nichols, Jennifer LaCorte, Melinda Mock, William Rogers, Fernando Ovalle, David Bell, Vijay K. Misra, William B. Hillegass, Raed Aqel, Penny Pierce, Melanie Smith, Leah Saag, Ashley Vaughn, Dwight Smith, Tiffany Grimes, Susan Rolli, Roberta Hill, Beth Dean Barrett, Clarinda Morehead, Ken Doss, Charles J. Davidson, Mark Molitch, Nirat Beohar, Elaine Massaro, Lynne Goodreau, Fabiola Arroyo, Petr Neužil, Lenka Pavlickova, Štĕpánka Stehlíková, Jaroslav Benedik, Liz Coling, Richard Davies, Christopher Glover, Michel LeMay, Thierry Mesana, Teik Chye Ooi, Mark Silverman, Alexander Sorisky, Colette Favreau, Susan McClinton, Melvin Weiss, Irene Weiss, Leo Saulle, Harichandra Kannam, Joanne C. Kurylas, Lorraine Vasi, John Douglas, Ziyad Ghazzal, Laurence Sperling, Spencer King, Priya Dayamani, Suzanne Gebhart, Sabreena Basu, Tarek Helmy, Vin Tangpricha, Pamela Hyde, Margaret Jenkins, Barbara P. Grant, Kenneth Kent, William Suddath, Michelle Magee, Patricia Julien-Williams, Vida Reed, Carine Nassar, Gilles Dagenais, Claude Garceau, Dominique Auger, Christopher Buller, Tom Elliott, Krishnan Ramanathan, Donald Ricci, Rebecca Fox, Daniela Kolesniak, Michael Attubato, Frederick Feit, Stephen Richardson, Ivan Pena Sing, James Slater, Angela Amendola, Bernardo Vargas, Nicholas Tsapatsaris, Bartholomew Woods, Gary Cushing, Martin Rutter, Premranjan Singh, Gail DesRochers, Gail Woodhead, Deborah Gannon, Nancy Shinopulos Campbell, Michael Ragosta, Ian Sarembock, Eric Powers, Eugene Barrett, Linda Jahn, Karen Murie, Gladwin Das, Gardar Sigurdsson, Carl White, John Bantle, J. Bruce Redmon, Christine Kwong, Jacqueline Tamis-Holland, Jeanine Albu, Judith S. Hochman, James Slater, James Wilentz, Sylvaine Frances, Deborah Tormey, Carl Pepine, Karen Smith, Laurence Kennedy, Karen Brezner, Tempa Curry, Frank Bleyer, Stewart Albert, Arshag Mooradian, Sharon Plummer, Francisco Fuentes, Roberto Robles, Victor Lavis, Jaime Gomez, Cesar Iliescu, Carol Underwood, Maria Selin Fulton, Julie Gomez Ramirez, Jennifer Merta, Glenna Scott, Ashok Krishnaswami, Lynn Dowdell, Sarah Berkheimer, Adam Greenbaum, Fred Whitehouse, Raquel Pangilinan, Kelly Mann, Alice K. Jacobs, Elliot Sternthal, Susana Ebner, Zoran Nedeljkovic, Paula Beardsley, David Schneider, Richard Pratley, William Cefalu, Joel Schnure, Michaelanne Rowen, Linda Tilton, Alan Niederman, Cristina Mata, Terri Kellerman, John Farmer, Alan J. Garber, Neal Kleiman, Nancy Howard, Debra Nichols, Madonna Pool, Thomas W Donner, Mark Feinglos, George Adams, Jennifer Green, Bernadette Druken, Dani Underwood, J. Lawrence Stafford, Thomas Donner, Warren Laskey, Dana Beach, John Lopez, Andrew Davis, David Faxon, Sirimon Reutrakul, Emily Bayer, Oscar Marroquin, Howard Cohen, Mary Korytkowski, Glory Koerbel, Lisa Baxendell, Debbie Rosenfelder, Louise DeRiso, Carole Farrell, Tina Vita, Janet McGill, Ronald Krone, Richard Bach, Carol Recklein, Kristin M. Luepke, Mary Jane Clifton, Michael E. Farkouh, Michael C. Kim, Donald A. Smith, Ida Guzman, Arlene Travis, James O'Keefe, Alan Forker, William Isley, Richard Moe, Paul Kennedy, Margaret Rosson, Aimee Long, Sheldon Gottlieb, Annabelle Rodriguez-Oquendo, Rodica Pop-Busui, Claire Duvernoy, Martin Stevens, Ann Luciano, Cheryl Majors, Sheldon H. Gottlieb, Annabelle Rodriguez, Melanie Herr, David Williams, Robert J. Smith, J. Dawn Abbott, Marc J. Laufgraben, Mary Grogan, Janice Muratori, Gabriel Habib, Marco Marcelli, Issam Mikati, Emilia Cordero, Gina Caldwell, David Schechter, Daniel Lorber, Phyllis August, Maisie Brown, Patricia Depree, Kurt Huber, Ursula Hanusch-Enserer, Nelly Jordanova, Dilek Cilesiz, Birgit Vogel, Ben McCallister, Michael Kleerekoper, Kelly Mandagere, Robert Urbanic, James Bengston, Bobby K. Kong, Andrew Pruitt, Jeffrey Sanfield, Carol Carulli, Ruth Churley-Strom, Raymond Magorien, Kwame Osei, Cecilia Casey Boyer, Richard Lee, Pasquale Palumbo, Joyce Wisbey, Edwin Alderman, Fumiaki Ikeno, Anne Schwarzkopf Michael Steffes, Maren Nowicki, Jean Bucksa, Bernard Chaitman, Jane Eckstein, Karen Stocke, Mark A. Hlatky, Derek B. Boothroyd, Kathryn A. Melsop, Burton E. Sobel, Michaelanne Rowen, Dagnija Neimane, Ami E. Iskandrian, Mary Beth Schaaf, Saul Genuth, Theresa Bongarno, Richard Nesto, Phyllis August, Karen Hultberg, Sheldon H. Gottlieb, Jeanine Albu, Helene Rosenhouse-Romeo, Trevor J. Orchard, Georgia Pambianco, Manuel Lombardero, Michael Mock, Robert L. Frye, Maria Mori Brooks, Patrice Desvigne-Nickens, Abby Ershow, Saul Genuth, Suzanne Goldberg, David Gordon, Regina Hardison, Teresa L Z Jones, Sheryl Kelsey, Richard Nesto, Trevor Orchard, Dina Paltoo, Yves Rosenberg, Thomas Ryan, Harold Lebovitz, Robert Brown, Gottlieb Friesinger, Edward Horton, Jay Mason, Renu Virmani, Lawrence Wechsler, C. Noel Bairey-Merz, J. Ward Kennedy, David Gordon, Elliott Antman, John Colwell, Sarah Fowler, Curt Furberg, Lee Goldman, Bruce Jennings, Scott Rankin

Research output: Contribution to journalArticle

Abstract

Background The extent of coronary disease affects clinical outcomes and may predict the effectiveness of coronary revascularization with either coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI). The SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score quantifies the extent of coronary disease. Objectives This study sought to determine whether SYNTAX scores predicted outcomes and the effectiveness of coronary revascularization compared with medical therapy in the BARI-2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial. Methods Baseline SYNTAX scores were retrospectively calculated for BARI-2D patients without prior revascularization (N = 1,550) by angiographic laboratory investigators masked to patient characteristics and outcomes. The primary outcome was major cardiovascular events (a composite of death, myocardial infarction, and stroke) over 5 years. Results A mid/high SYNTAX score (≥23) was associated with a higher risk of major cardiovascular events (hazard ratio: 1.36, confidence interval: 1.07 to 1.75, p = 0.01). Patients in the CABG stratum had significantly higher SYNTAX scores: 36% had mid/high SYNTAX scores compared with 13% in the PCI stratum (p < 0.001). Among patients with low SYNTAX scores (≤22), major cardiovascular events did not differ significantly between revascularization and medical therapy, either in the CABG stratum (26.1% vs. 29.9%, p = 0.41) or in the PCI stratum (17.8% vs. 19.2%, p = 0.84). Among patients with mid/high SYNTAX scores, however, major cardiovascular events were lower after revascularization than with medical therapy in the CABG stratum (15.3% vs. 30.3%, p = 0.02), but not in the PCI stratum (35.6% vs. 26.5%, p = 0.12). Conclusions Among patients with diabetes and stable ischemic heart disease, higher SYNTAX scores predict higher rates of major cardiovascular events and were associated with more favorable outcomes of revascularization compared with medical therapy among patients suitable for CABG. (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes; NCT00006305)

Original languageEnglish (US)
Pages (from-to)395-403
Number of pages9
JournalJournal of the American College of Cardiology
Volume69
Issue number4
DOIs
StatePublished - Jan 31 2017

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Angioplasty
Percutaneous Coronary Intervention
Coronary Artery Bypass
Transplants
Coronary Disease
Taxus
Therapeutics
Type 2 Diabetes Mellitus
Thoracic Surgery
Myocardial Ischemia
Stroke
Myocardial Infarction
Research Personnel
Confidence Intervals

Keywords

  • angiography
  • coronary disease
  • ischemia
  • prognosis
  • stents
  • surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ikeno, F., Brooks, M. M., Nakagawa, K., Kim, M. K., Kaneda, H., Mitsutake, Y., ... Rankin, S. (2017). SYNTAX Score and Long-Term Outcomes: The BARI-2D Trial. Journal of the American College of Cardiology, 69(4), 395-403. https://doi.org/10.1016/j.jacc.2016.10.067

SYNTAX Score and Long-Term Outcomes : The BARI-2D Trial. / Ikeno, Fumiaki; Brooks, Maria Mori; Nakagawa, Kaori; Kim, Min Kyu; Kaneda, Hideaki; Mitsutake, Yoshiaki; Vlachos, Helen A.; Schwartz, Leonard; Frye, Robert L.; Kelsey, Sheryl F.; Waseda, Katsuhisa; Hlatky, Mark A.; Detre, Katherine M.; Kelsey, Sheryl F.; Brooks, Maria Mori; Orchard, Trevor J.; Thomas, Stephen B.; Tyrrell, Kim Sutton; Rana, Jamal S.; Averbach, Frani; MacGregor, Joan M.; O'Neal, Scott M.; Pitluga, Kathleen; Sansing, Veronica; Tranchine, Mary; Crow, Sharon W.; Bertolet, Marianne (Marnie); Hardison, Regina; Kip, Kevin; Lombardero, Manuel; Lu, Jiang; Janiszewski, Sue; Protivnak, Darina; Reiser, Sarah; Barton, Stephen; Guo, Ping; Kushner, Yulia; Michael, Owen; Martin, Jeffrey P.; Kania, Christopher; Kania, Michael; O'Donnell, Jeffrey; Maxwell, Rae Ann; Frye, Robert L.; Goldberg, Suzanne; Rosenberg, Yves; Desvigne-Nickens, Patrice; Ershow, Abby; Gordon, David; Paltoo, Dina; Jones, Teresa L Z; Hueb, Whady; Ramires, José; Lopes, Neuza; Wajchenberg, Bernardo Léo; Martinez, Eulogio E.; Oliveira, Sergio A.; Ribeiro, Expedito E.; Perin, Marcos; Betti, Roberto; Schwartz, Leonard; Steiner, George; Barolet, Alan; Groenewoud, Yolanda; Mighton, Lisa; Camelon, Kathy; O'Rourke, Robert; Blodgett, Janet; Sako, Edward; Nicastro, Judith; Prescott, Robin; Rihal, Charanjit; Kennedy, Frank; Barsness, Gregory; Basu, Amanda; Clavell, Alfredo; Frye, Robert; Holmes, David R.; Lerman, Amir; Mullaney, Charles; Reeder, Guy; Rizza, Robert; Schaff, Hartzell; Smith, Steven; Somers, Virend; Sundt, Thoralf; Ting, Henry; Wright, R. Scott; Helgemoe, Pam; Lesmeister, Diane; Rolbiecki, Deborah; Lepe-Montoya, Luis; Escobedo, Jorge; Barraza, Rafael; Baleón, Rubén; Campos, Arturo; García, Paula; Lezama, Carlos; Miramontes, Carlos; Ocampo, Salvador; Peñafiel, Joaquín V.; Valdespino, Aquiles; Verdín, Raúl; Albarrán, Héctor; Ayala, Fernando; Chávez, Eduardo; Murillo, Héctor; Buitrón, Luisa Virginia; Rico-Verdin, Beatriz; Angulo, Fabiola; Adler, Dale; Halle, Austin Arthur; Ismail-Beigi, Faramarz; Paranjape, Suvinay; Mazzurco, Stacey; Ridley, Karen; Ramanathan, Kodangudi; Solomon, Solomon; Wall, Barry; Weinman, Darryl; Touchstone, Tammy; Douglas, Lillie; Bourassa, Martial; Tardif, Jean Claude; Chiasson, Jean Louis; Lavoie, Marc Andre; Rabasa-Lhoret, Rémi; Langelier, Hélène; Foucher, Suzy; Trudel, Johanne; Monrad, Scott; Srinivas, Vankeepuram; Zonszein, Joel; Crandall, Jill; Duffy, Helena; Vartolomei, Eugen; King, Spencer; Jacobs, Carl; Robertson, David; Porter, Marty; Eley, Melanie; Nichols, Emmalee; LaCorte, Jennifer; Mock, Melinda; Rogers, William; Ovalle, Fernando; Bell, David; Misra, Vijay K.; Hillegass, William B.; Aqel, Raed; Pierce, Penny; Smith, Melanie; Saag, Leah; Vaughn, Ashley; Smith, Dwight; Grimes, Tiffany; Rolli, Susan; Hill, Roberta; Barrett, Beth Dean; Morehead, Clarinda; Doss, Ken; Davidson, Charles J.; Molitch, Mark; Beohar, Nirat; Massaro, Elaine; Goodreau, Lynne; Arroyo, Fabiola; Neužil, Petr; Pavlickova, Lenka; Stehlíková, Štĕpánka; Benedik, Jaroslav; Coling, Liz; Davies, Richard; Glover, Christopher; LeMay, Michel; Mesana, Thierry; Ooi, Teik Chye; Silverman, Mark; Sorisky, Alexander; Favreau, Colette; McClinton, Susan; Weiss, Melvin; Weiss, Irene; Saulle, Leo; Kannam, Harichandra; Kurylas, Joanne C.; Vasi, Lorraine; Douglas, John; Ghazzal, Ziyad; Sperling, Laurence; King, Spencer; Dayamani, Priya; Gebhart, Suzanne; Basu, Sabreena; Helmy, Tarek; Tangpricha, Vin; Hyde, Pamela; Jenkins, Margaret; Grant, Barbara P.; Kent, Kenneth; Suddath, William; Magee, Michelle; Julien-Williams, Patricia; Reed, Vida; Nassar, Carine; Dagenais, Gilles; Garceau, Claude; Auger, Dominique; Buller, Christopher; Elliott, Tom; Ramanathan, Krishnan; Ricci, Donald; Fox, Rebecca; Kolesniak, Daniela; Attubato, Michael; Feit, Frederick; Richardson, Stephen; Sing, Ivan Pena; Slater, James; Amendola, Angela; Vargas, Bernardo; Tsapatsaris, Nicholas; Woods, Bartholomew; Cushing, Gary; Rutter, Martin; Singh, Premranjan; DesRochers, Gail; Woodhead, Gail; Gannon, Deborah; Campbell, Nancy Shinopulos; Ragosta, Michael; Sarembock, Ian; Powers, Eric; Barrett, Eugene; Jahn, Linda; Murie, Karen; Das, Gladwin; Sigurdsson, Gardar; White, Carl; Bantle, John; Redmon, J. Bruce; Kwong, Christine; Tamis-Holland, Jacqueline; Albu, Jeanine; Hochman, Judith S.; Slater, James; Wilentz, James; Frances, Sylvaine; Tormey, Deborah; Pepine, Carl; Smith, Karen; Kennedy, Laurence; Brezner, Karen; Curry, Tempa; Bleyer, Frank; Albert, Stewart; Mooradian, Arshag; Plummer, Sharon; Fuentes, Francisco; Robles, Roberto; Lavis, Victor; Gomez, Jaime; Iliescu, Cesar; Underwood, Carol; Fulton, Maria Selin; Ramirez, Julie Gomez; Merta, Jennifer; Scott, Glenna; Krishnaswami, Ashok; Dowdell, Lynn; Berkheimer, Sarah; Greenbaum, Adam; Whitehouse, Fred; Pangilinan, Raquel; Mann, Kelly; Jacobs, Alice K.; Sternthal, Elliot; Ebner, Susana; Nedeljkovic, Zoran; Beardsley, Paula; Schneider, David; Pratley, Richard; Cefalu, William; Schnure, Joel; Rowen, Michaelanne; Tilton, Linda; Niederman, Alan; Mata, Cristina; Kellerman, Terri; Farmer, John; Garber, Alan J.; Kleiman, Neal; Howard, Nancy; Nichols, Debra; Pool, Madonna; Donner, Thomas W; Feinglos, Mark; Adams, George; Green, Jennifer; Druken, Bernadette; Underwood, Dani; Stafford, J. Lawrence; Donner, Thomas; Laskey, Warren; Beach, Dana; Lopez, John; Davis, Andrew; Faxon, David; Reutrakul, Sirimon; Bayer, Emily; Marroquin, Oscar; Cohen, Howard; Korytkowski, Mary; Koerbel, Glory; Baxendell, Lisa; Rosenfelder, Debbie; DeRiso, Louise; Farrell, Carole; Vita, Tina; McGill, Janet; Krone, Ronald; Bach, Richard; Recklein, Carol; Luepke, Kristin M.; Clifton, Mary Jane; Farkouh, Michael E.; Kim, Michael C.; Smith, Donald A.; Guzman, Ida; Travis, Arlene; O'Keefe, James; Forker, Alan; Isley, William; Moe, Richard; Kennedy, Paul; Rosson, Margaret; Long, Aimee; Gottlieb, Sheldon; Rodriguez-Oquendo, Annabelle; Pop-Busui, Rodica; Duvernoy, Claire; Stevens, Martin; Luciano, Ann; Majors, Cheryl; Gottlieb, Sheldon H.; Rodriguez, Annabelle; Herr, Melanie; Williams, David; Smith, Robert J.; Abbott, J. Dawn; Laufgraben, Marc J.; Grogan, Mary; Muratori, Janice; Habib, Gabriel; Marcelli, Marco; Mikati, Issam; Cordero, Emilia; Caldwell, Gina; Schechter, David; Lorber, Daniel; August, Phyllis; Brown, Maisie; Depree, Patricia; Huber, Kurt; Hanusch-Enserer, Ursula; Jordanova, Nelly; Cilesiz, Dilek; Vogel, Birgit; McCallister, Ben; Kleerekoper, Michael; Mandagere, Kelly; Urbanic, Robert; Bengston, James; Kong, Bobby K.; Pruitt, Andrew; Sanfield, Jeffrey; Carulli, Carol; Churley-Strom, Ruth; Magorien, Raymond; Osei, Kwame; Boyer, Cecilia Casey; Lee, Richard; Palumbo, Pasquale; Wisbey, Joyce; Alderman, Edwin; Ikeno, Fumiaki; Michael Steffes, Anne Schwarzkopf; Nowicki, Maren; Bucksa, Jean; Chaitman, Bernard; Eckstein, Jane; Stocke, Karen; Hlatky, Mark A.; Boothroyd, Derek B.; Melsop, Kathryn A.; Sobel, Burton E.; Rowen, Michaelanne; Neimane, Dagnija; Iskandrian, Ami E.; Schaaf, Mary Beth; Genuth, Saul; Bongarno, Theresa; Nesto, Richard; August, Phyllis; Hultberg, Karen; Gottlieb, Sheldon H.; Albu, Jeanine; Rosenhouse-Romeo, Helene; Orchard, Trevor J.; Pambianco, Georgia; Lombardero, Manuel; Mock, Michael; Frye, Robert L.; Brooks, Maria Mori; Desvigne-Nickens, Patrice; Ershow, Abby; Genuth, Saul; Goldberg, Suzanne; Gordon, David; Hardison, Regina; Jones, Teresa L Z; Kelsey, Sheryl; Nesto, Richard; Orchard, Trevor; Paltoo, Dina; Rosenberg, Yves; Ryan, Thomas; Lebovitz, Harold; Brown, Robert; Friesinger, Gottlieb; Horton, Edward; Mason, Jay; Virmani, Renu; Wechsler, Lawrence; Bairey-Merz, C. Noel; Kennedy, J. Ward; Gordon, David; Antman, Elliott; Colwell, John; Fowler, Sarah; Furberg, Curt; Goldman, Lee; Jennings, Bruce; Rankin, Scott.

In: Journal of the American College of Cardiology, Vol. 69, No. 4, 31.01.2017, p. 395-403.

Research output: Contribution to journalArticle

Ikeno, F, Brooks, MM, Nakagawa, K, Kim, MK, Kaneda, H, Mitsutake, Y, Vlachos, HA, Schwartz, L, Frye, RL, Kelsey, SF, Waseda, K, Hlatky, MA, Detre, KM, Kelsey, SF, Brooks, MM, Orchard, TJ, Thomas, SB, Tyrrell, KS, Rana, JS, Averbach, F, MacGregor, JM, O'Neal, SM, Pitluga, K, Sansing, V, Tranchine, M, Crow, SW, Bertolet, MM, Hardison, R, Kip, K, Lombardero, M, Lu, J, Janiszewski, S, Protivnak, D, Reiser, S, Barton, S, Guo, P, Kushner, Y, Michael, O, Martin, JP, Kania, C, Kania, M, O'Donnell, J, Maxwell, RA, Frye, RL, Goldberg, S, Rosenberg, Y, Desvigne-Nickens, P, Ershow, A, Gordon, D, Paltoo, D, Jones, TLZ, Hueb, W, Ramires, J, Lopes, N, Wajchenberg, BL, Martinez, EE, Oliveira, SA, Ribeiro, EE, Perin, M, Betti, R, Schwartz, L, Steiner, G, Barolet, A, Groenewoud, Y, Mighton, L, Camelon, K, O'Rourke, R, Blodgett, J, Sako, E, Nicastro, J, Prescott, R, Rihal, C, Kennedy, F, Barsness, G, Basu, A, Clavell, A, Frye, R, Holmes, DR, Lerman, A, Mullaney, C, Reeder, G, Rizza, R, Schaff, H, Smith, S, Somers, V, Sundt, T, Ting, H, Wright, RS, Helgemoe, P, Lesmeister, D, Rolbiecki, D, Lepe-Montoya, L, Escobedo, J, Barraza, R, Baleón, R, Campos, A, García, P, Lezama, C, Miramontes, C, Ocampo, S, Peñafiel, JV, Valdespino, A, Verdín, R, Albarrán, H, Ayala, F, Chávez, E, Murillo, H, Buitrón, LV, Rico-Verdin, B, Angulo, F, Adler, D, Halle, AA, Ismail-Beigi, F, Paranjape, S, Mazzurco, S, Ridley, K, Ramanathan, K, Solomon, S, Wall, B, Weinman, D, Touchstone, T, Douglas, L, Bourassa, M, Tardif, JC, Chiasson, JL, Lavoie, MA, Rabasa-Lhoret, R, Langelier, H, Foucher, S, Trudel, J, Monrad, S, Srinivas, V, Zonszein, J, Crandall, J, Duffy, H, Vartolomei, E, King, S, Jacobs, C, Robertson, D, Porter, M, Eley, M, Nichols, E, LaCorte, J, Mock, M, Rogers, W, Ovalle, F, Bell, D, Misra, VK, Hillegass, WB, Aqel, R, Pierce, P, Smith, M, Saag, L, Vaughn, A, Smith, D, Grimes, T, Rolli, S, Hill, R, Barrett, BD, Morehead, C, Doss, K, Davidson, CJ, Molitch, M, Beohar, N, Massaro, E, Goodreau, L, Arroyo, F, Neužil, P, Pavlickova, L, Stehlíková, Š, Benedik, J, Coling, L, Davies, R, Glover, C, LeMay, M, Mesana, T, Ooi, TC, Silverman, M, Sorisky, A, Favreau, C, McClinton, S, Weiss, M, Weiss, I, Saulle, L, Kannam, H, Kurylas, JC, Vasi, L, Douglas, J, Ghazzal, Z, Sperling, L, King, S, Dayamani, P, Gebhart, S, Basu, S, Helmy, T, Tangpricha, V, Hyde, P, Jenkins, M, Grant, BP, Kent, K, Suddath, W, Magee, M, Julien-Williams, P, Reed, V, Nassar, C, Dagenais, G, Garceau, C, Auger, D, Buller, C, Elliott, T, Ramanathan, K, Ricci, D, Fox, R, Kolesniak, D, Attubato, M, Feit, F, Richardson, S, Sing, IP, Slater, J, Amendola, A, Vargas, B, Tsapatsaris, N, Woods, B, Cushing, G, Rutter, M, Singh, P, DesRochers, G, Woodhead, G, Gannon, D, Campbell, NS, Ragosta, M, Sarembock, I, Powers, E, Barrett, E, Jahn, L, Murie, K, Das, G, Sigurdsson, G, White, C, Bantle, J, Redmon, JB, Kwong, C, Tamis-Holland, J, Albu, J, Hochman, JS, Slater, J, Wilentz, J, Frances, S, Tormey, D, Pepine, C, Smith, K, Kennedy, L, Brezner, K, Curry, T, Bleyer, F, Albert, S, Mooradian, A, Plummer, S, Fuentes, F, Robles, R, Lavis, V, Gomez, J, Iliescu, C, Underwood, C, Fulton, MS, Ramirez, JG, Merta, J, Scott, G, Krishnaswami, A, Dowdell, L, Berkheimer, S, Greenbaum, A, Whitehouse, F, Pangilinan, R, Mann, K, Jacobs, AK, Sternthal, E, Ebner, S, Nedeljkovic, Z, Beardsley, P, Schneider, D, Pratley, R, Cefalu, W, Schnure, J, Rowen, M, Tilton, L, Niederman, A, Mata, C, Kellerman, T, Farmer, J, Garber, AJ, Kleiman, N, Howard, N, Nichols, D, Pool, M, Donner, TW, Feinglos, M, Adams, G, Green, J, Druken, B, Underwood, D, Stafford, JL, Donner, T, Laskey, W, Beach, D, Lopez, J, Davis, A, Faxon, D, Reutrakul, S, Bayer, E, Marroquin, O, Cohen, H, Korytkowski, M, Koerbel, G, Baxendell, L, Rosenfelder, D, DeRiso, L, Farrell, C, Vita, T, McGill, J, Krone, R, Bach, R, Recklein, C, Luepke, KM, Clifton, MJ, Farkouh, ME, Kim, MC, Smith, DA, Guzman, I, Travis, A, O'Keefe, J, Forker, A, Isley, W, Moe, R, Kennedy, P, Rosson, M, Long, A, Gottlieb, S, Rodriguez-Oquendo, A, Pop-Busui, R, Duvernoy, C, Stevens, M, Luciano, A, Majors, C, Gottlieb, SH, Rodriguez, A, Herr, M, Williams, D, Smith, RJ, Abbott, JD, Laufgraben, MJ, Grogan, M, Muratori, J, Habib, G, Marcelli, M, Mikati, I, Cordero, E, Caldwell, G, Schechter, D, Lorber, D, August, P, Brown, M, Depree, P, Huber, K, Hanusch-Enserer, U, Jordanova, N, Cilesiz, D, Vogel, B, McCallister, B, Kleerekoper, M, Mandagere, K, Urbanic, R, Bengston, J, Kong, BK, Pruitt, A, Sanfield, J, Carulli, C, Churley-Strom, R, Magorien, R, Osei, K, Boyer, CC, Lee, R, Palumbo, P, Wisbey, J, Alderman, E, Ikeno, F, Michael Steffes, AS, Nowicki, M, Bucksa, J, Chaitman, B, Eckstein, J, Stocke, K, Hlatky, MA, Boothroyd, DB, Melsop, KA, Sobel, BE, Rowen, M, Neimane, D, Iskandrian, AE, Schaaf, MB, Genuth, S, Bongarno, T, Nesto, R, August, P, Hultberg, K, Gottlieb, SH, Albu, J, Rosenhouse-Romeo, H, Orchard, TJ, Pambianco, G, Lombardero, M, Mock, M, Frye, RL, Brooks, MM, Desvigne-Nickens, P, Ershow, A, Genuth, S, Goldberg, S, Gordon, D, Hardison, R, Jones, TLZ, Kelsey, S, Nesto, R, Orchard, T, Paltoo, D, Rosenberg, Y, Ryan, T, Lebovitz, H, Brown, R, Friesinger, G, Horton, E, Mason, J, Virmani, R, Wechsler, L, Bairey-Merz, CN, Kennedy, JW, Gordon, D, Antman, E, Colwell, J, Fowler, S, Furberg, C, Goldman, L, Jennings, B & Rankin, S 2017, 'SYNTAX Score and Long-Term Outcomes: The BARI-2D Trial', Journal of the American College of Cardiology, vol. 69, no. 4, pp. 395-403. https://doi.org/10.1016/j.jacc.2016.10.067
Ikeno F, Brooks MM, Nakagawa K, Kim MK, Kaneda H, Mitsutake Y et al. SYNTAX Score and Long-Term Outcomes: The BARI-2D Trial. Journal of the American College of Cardiology. 2017 Jan 31;69(4):395-403. https://doi.org/10.1016/j.jacc.2016.10.067
Ikeno, Fumiaki ; Brooks, Maria Mori ; Nakagawa, Kaori ; Kim, Min Kyu ; Kaneda, Hideaki ; Mitsutake, Yoshiaki ; Vlachos, Helen A. ; Schwartz, Leonard ; Frye, Robert L. ; Kelsey, Sheryl F. ; Waseda, Katsuhisa ; Hlatky, Mark A. ; Detre, Katherine M. ; Kelsey, Sheryl F. ; Brooks, Maria Mori ; Orchard, Trevor J. ; Thomas, Stephen B. ; Tyrrell, Kim Sutton ; Rana, Jamal S. ; Averbach, Frani ; MacGregor, Joan M. ; O'Neal, Scott M. ; Pitluga, Kathleen ; Sansing, Veronica ; Tranchine, Mary ; Crow, Sharon W. ; Bertolet, Marianne (Marnie) ; Hardison, Regina ; Kip, Kevin ; Lombardero, Manuel ; Lu, Jiang ; Janiszewski, Sue ; Protivnak, Darina ; Reiser, Sarah ; Barton, Stephen ; Guo, Ping ; Kushner, Yulia ; Michael, Owen ; Martin, Jeffrey P. ; Kania, Christopher ; Kania, Michael ; O'Donnell, Jeffrey ; Maxwell, Rae Ann ; Frye, Robert L. ; Goldberg, Suzanne ; Rosenberg, Yves ; Desvigne-Nickens, Patrice ; Ershow, Abby ; Gordon, David ; Paltoo, Dina ; Jones, Teresa L Z ; Hueb, Whady ; Ramires, José ; Lopes, Neuza ; Wajchenberg, Bernardo Léo ; Martinez, Eulogio E. ; Oliveira, Sergio A. ; Ribeiro, Expedito E. ; Perin, Marcos ; Betti, Roberto ; Schwartz, Leonard ; Steiner, George ; Barolet, Alan ; Groenewoud, Yolanda ; Mighton, Lisa ; Camelon, Kathy ; O'Rourke, Robert ; Blodgett, Janet ; Sako, Edward ; Nicastro, Judith ; Prescott, Robin ; Rihal, Charanjit ; Kennedy, Frank ; Barsness, Gregory ; Basu, Amanda ; Clavell, Alfredo ; Frye, Robert ; Holmes, David R. ; Lerman, Amir ; Mullaney, Charles ; Reeder, Guy ; Rizza, Robert ; Schaff, Hartzell ; Smith, Steven ; Somers, Virend ; Sundt, Thoralf ; Ting, Henry ; Wright, R. Scott ; Helgemoe, Pam ; Lesmeister, Diane ; Rolbiecki, Deborah ; Lepe-Montoya, Luis ; Escobedo, Jorge ; Barraza, Rafael ; Baleón, Rubén ; Campos, Arturo ; García, Paula ; Lezama, Carlos ; Miramontes, Carlos ; Ocampo, Salvador ; Peñafiel, Joaquín V. ; Valdespino, Aquiles ; Verdín, Raúl ; Albarrán, Héctor ; Ayala, Fernando ; Chávez, Eduardo ; Murillo, Héctor ; Buitrón, Luisa Virginia ; Rico-Verdin, Beatriz ; Angulo, Fabiola ; Adler, Dale ; Halle, Austin Arthur ; Ismail-Beigi, Faramarz ; Paranjape, Suvinay ; Mazzurco, Stacey ; Ridley, Karen ; Ramanathan, Kodangudi ; Solomon, Solomon ; Wall, Barry ; Weinman, Darryl ; Touchstone, Tammy ; Douglas, Lillie ; Bourassa, Martial ; Tardif, Jean Claude ; Chiasson, Jean Louis ; Lavoie, Marc Andre ; Rabasa-Lhoret, Rémi ; Langelier, Hélène ; Foucher, Suzy ; Trudel, Johanne ; Monrad, Scott ; Srinivas, Vankeepuram ; Zonszein, Joel ; Crandall, Jill ; Duffy, Helena ; Vartolomei, Eugen ; King, Spencer ; Jacobs, Carl ; Robertson, David ; Porter, Marty ; Eley, Melanie ; Nichols, Emmalee ; LaCorte, Jennifer ; Mock, Melinda ; Rogers, William ; Ovalle, Fernando ; Bell, David ; Misra, Vijay K. ; Hillegass, William B. ; Aqel, Raed ; Pierce, Penny ; Smith, Melanie ; Saag, Leah ; Vaughn, Ashley ; Smith, Dwight ; Grimes, Tiffany ; Rolli, Susan ; Hill, Roberta ; Barrett, Beth Dean ; Morehead, Clarinda ; Doss, Ken ; Davidson, Charles J. ; Molitch, Mark ; Beohar, Nirat ; Massaro, Elaine ; Goodreau, Lynne ; Arroyo, Fabiola ; Neužil, Petr ; Pavlickova, Lenka ; Stehlíková, Štĕpánka ; Benedik, Jaroslav ; Coling, Liz ; Davies, Richard ; Glover, Christopher ; LeMay, Michel ; Mesana, Thierry ; Ooi, Teik Chye ; Silverman, Mark ; Sorisky, Alexander ; Favreau, Colette ; McClinton, Susan ; Weiss, Melvin ; Weiss, Irene ; Saulle, Leo ; Kannam, Harichandra ; Kurylas, Joanne C. ; Vasi, Lorraine ; Douglas, John ; Ghazzal, Ziyad ; Sperling, Laurence ; King, Spencer ; Dayamani, Priya ; Gebhart, Suzanne ; Basu, Sabreena ; Helmy, Tarek ; Tangpricha, Vin ; Hyde, Pamela ; Jenkins, Margaret ; Grant, Barbara P. ; Kent, Kenneth ; Suddath, William ; Magee, Michelle ; Julien-Williams, Patricia ; Reed, Vida ; Nassar, Carine ; Dagenais, Gilles ; Garceau, Claude ; Auger, Dominique ; Buller, Christopher ; Elliott, Tom ; Ramanathan, Krishnan ; Ricci, Donald ; Fox, Rebecca ; Kolesniak, Daniela ; Attubato, Michael ; Feit, Frederick ; Richardson, Stephen ; Sing, Ivan Pena ; Slater, James ; Amendola, Angela ; Vargas, Bernardo ; Tsapatsaris, Nicholas ; Woods, Bartholomew ; Cushing, Gary ; Rutter, Martin ; Singh, Premranjan ; DesRochers, Gail ; Woodhead, Gail ; Gannon, Deborah ; Campbell, Nancy Shinopulos ; Ragosta, Michael ; Sarembock, Ian ; Powers, Eric ; Barrett, Eugene ; Jahn, Linda ; Murie, Karen ; Das, Gladwin ; Sigurdsson, Gardar ; White, Carl ; Bantle, John ; Redmon, J. Bruce ; Kwong, Christine ; Tamis-Holland, Jacqueline ; Albu, Jeanine ; Hochman, Judith S. ; Slater, James ; Wilentz, James ; Frances, Sylvaine ; Tormey, Deborah ; Pepine, Carl ; Smith, Karen ; Kennedy, Laurence ; Brezner, Karen ; Curry, Tempa ; Bleyer, Frank ; Albert, Stewart ; Mooradian, Arshag ; Plummer, Sharon ; Fuentes, Francisco ; Robles, Roberto ; Lavis, Victor ; Gomez, Jaime ; Iliescu, Cesar ; Underwood, Carol ; Fulton, Maria Selin ; Ramirez, Julie Gomez ; Merta, Jennifer ; Scott, Glenna ; Krishnaswami, Ashok ; Dowdell, Lynn ; Berkheimer, Sarah ; Greenbaum, Adam ; Whitehouse, Fred ; Pangilinan, Raquel ; Mann, Kelly ; Jacobs, Alice K. ; Sternthal, Elliot ; Ebner, Susana ; Nedeljkovic, Zoran ; Beardsley, Paula ; Schneider, David ; Pratley, Richard ; Cefalu, William ; Schnure, Joel ; Rowen, Michaelanne ; Tilton, Linda ; Niederman, Alan ; Mata, Cristina ; Kellerman, Terri ; Farmer, John ; Garber, Alan J. ; Kleiman, Neal ; Howard, Nancy ; Nichols, Debra ; Pool, Madonna ; Donner, Thomas W ; Feinglos, Mark ; Adams, George ; Green, Jennifer ; Druken, Bernadette ; Underwood, Dani ; Stafford, J. Lawrence ; Donner, Thomas ; Laskey, Warren ; Beach, Dana ; Lopez, John ; Davis, Andrew ; Faxon, David ; Reutrakul, Sirimon ; Bayer, Emily ; Marroquin, Oscar ; Cohen, Howard ; Korytkowski, Mary ; Koerbel, Glory ; Baxendell, Lisa ; Rosenfelder, Debbie ; DeRiso, Louise ; Farrell, Carole ; Vita, Tina ; McGill, Janet ; Krone, Ronald ; Bach, Richard ; Recklein, Carol ; Luepke, Kristin M. ; Clifton, Mary Jane ; Farkouh, Michael E. ; Kim, Michael C. ; Smith, Donald A. ; Guzman, Ida ; Travis, Arlene ; O'Keefe, James ; Forker, Alan ; Isley, William ; Moe, Richard ; Kennedy, Paul ; Rosson, Margaret ; Long, Aimee ; Gottlieb, Sheldon ; Rodriguez-Oquendo, Annabelle ; Pop-Busui, Rodica ; Duvernoy, Claire ; Stevens, Martin ; Luciano, Ann ; Majors, Cheryl ; Gottlieb, Sheldon H. ; Rodriguez, Annabelle ; Herr, Melanie ; Williams, David ; Smith, Robert J. ; Abbott, J. Dawn ; Laufgraben, Marc J. ; Grogan, Mary ; Muratori, Janice ; Habib, Gabriel ; Marcelli, Marco ; Mikati, Issam ; Cordero, Emilia ; Caldwell, Gina ; Schechter, David ; Lorber, Daniel ; August, Phyllis ; Brown, Maisie ; Depree, Patricia ; Huber, Kurt ; Hanusch-Enserer, Ursula ; Jordanova, Nelly ; Cilesiz, Dilek ; Vogel, Birgit ; McCallister, Ben ; Kleerekoper, Michael ; Mandagere, Kelly ; Urbanic, Robert ; Bengston, James ; Kong, Bobby K. ; Pruitt, Andrew ; Sanfield, Jeffrey ; Carulli, Carol ; Churley-Strom, Ruth ; Magorien, Raymond ; Osei, Kwame ; Boyer, Cecilia Casey ; Lee, Richard ; Palumbo, Pasquale ; Wisbey, Joyce ; Alderman, Edwin ; Ikeno, Fumiaki ; Michael Steffes, Anne Schwarzkopf ; Nowicki, Maren ; Bucksa, Jean ; Chaitman, Bernard ; Eckstein, Jane ; Stocke, Karen ; Hlatky, Mark A. ; Boothroyd, Derek B. ; Melsop, Kathryn A. ; Sobel, Burton E. ; Rowen, Michaelanne ; Neimane, Dagnija ; Iskandrian, Ami E. ; Schaaf, Mary Beth ; Genuth, Saul ; Bongarno, Theresa ; Nesto, Richard ; August, Phyllis ; Hultberg, Karen ; Gottlieb, Sheldon H. ; Albu, Jeanine ; Rosenhouse-Romeo, Helene ; Orchard, Trevor J. ; Pambianco, Georgia ; Lombardero, Manuel ; Mock, Michael ; Frye, Robert L. ; Brooks, Maria Mori ; Desvigne-Nickens, Patrice ; Ershow, Abby ; Genuth, Saul ; Goldberg, Suzanne ; Gordon, David ; Hardison, Regina ; Jones, Teresa L Z ; Kelsey, Sheryl ; Nesto, Richard ; Orchard, Trevor ; Paltoo, Dina ; Rosenberg, Yves ; Ryan, Thomas ; Lebovitz, Harold ; Brown, Robert ; Friesinger, Gottlieb ; Horton, Edward ; Mason, Jay ; Virmani, Renu ; Wechsler, Lawrence ; Bairey-Merz, C. Noel ; Kennedy, J. Ward ; Gordon, David ; Antman, Elliott ; Colwell, John ; Fowler, Sarah ; Furberg, Curt ; Goldman, Lee ; Jennings, Bruce ; Rankin, Scott. / SYNTAX Score and Long-Term Outcomes : The BARI-2D Trial. In: Journal of the American College of Cardiology. 2017 ; Vol. 69, No. 4. pp. 395-403.
@article{af5b2c25a9444ab6ad98ded03b65181a,
title = "SYNTAX Score and Long-Term Outcomes: The BARI-2D Trial",
abstract = "Background The extent of coronary disease affects clinical outcomes and may predict the effectiveness of coronary revascularization with either coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI). The SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score quantifies the extent of coronary disease. Objectives This study sought to determine whether SYNTAX scores predicted outcomes and the effectiveness of coronary revascularization compared with medical therapy in the BARI-2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial. Methods Baseline SYNTAX scores were retrospectively calculated for BARI-2D patients without prior revascularization (N = 1,550) by angiographic laboratory investigators masked to patient characteristics and outcomes. The primary outcome was major cardiovascular events (a composite of death, myocardial infarction, and stroke) over 5 years. Results A mid/high SYNTAX score (≥23) was associated with a higher risk of major cardiovascular events (hazard ratio: 1.36, confidence interval: 1.07 to 1.75, p = 0.01). Patients in the CABG stratum had significantly higher SYNTAX scores: 36{\%} had mid/high SYNTAX scores compared with 13{\%} in the PCI stratum (p < 0.001). Among patients with low SYNTAX scores (≤22), major cardiovascular events did not differ significantly between revascularization and medical therapy, either in the CABG stratum (26.1{\%} vs. 29.9{\%}, p = 0.41) or in the PCI stratum (17.8{\%} vs. 19.2{\%}, p = 0.84). Among patients with mid/high SYNTAX scores, however, major cardiovascular events were lower after revascularization than with medical therapy in the CABG stratum (15.3{\%} vs. 30.3{\%}, p = 0.02), but not in the PCI stratum (35.6{\%} vs. 26.5{\%}, p = 0.12). Conclusions Among patients with diabetes and stable ischemic heart disease, higher SYNTAX scores predict higher rates of major cardiovascular events and were associated with more favorable outcomes of revascularization compared with medical therapy among patients suitable for CABG. (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes; NCT00006305)",
keywords = "angiography, coronary disease, ischemia, prognosis, stents, surgery",
author = "Fumiaki Ikeno and Brooks, {Maria Mori} and Kaori Nakagawa and Kim, {Min Kyu} and Hideaki Kaneda and Yoshiaki Mitsutake and Vlachos, {Helen A.} and Leonard Schwartz and Frye, {Robert L.} and Kelsey, {Sheryl F.} and Katsuhisa Waseda and Hlatky, {Mark A.} and Detre, {Katherine M.} and Kelsey, {Sheryl F.} and Brooks, {Maria Mori} and Orchard, {Trevor J.} and Thomas, {Stephen B.} and Tyrrell, {Kim Sutton} and Rana, {Jamal S.} and Frani Averbach and MacGregor, {Joan M.} and O'Neal, {Scott M.} and Kathleen Pitluga and Veronica Sansing and Mary Tranchine and Crow, {Sharon W.} and Bertolet, {Marianne (Marnie)} and Regina Hardison and Kevin Kip and Manuel Lombardero and Jiang Lu and Sue Janiszewski and Darina Protivnak and Sarah Reiser and Stephen Barton and Ping Guo and Yulia Kushner and Owen Michael and Martin, {Jeffrey P.} and Christopher Kania and Michael Kania and Jeffrey O'Donnell and Maxwell, {Rae Ann} and Frye, {Robert L.} and Suzanne Goldberg and Yves Rosenberg and Patrice Desvigne-Nickens and Abby Ershow and David Gordon and Dina Paltoo and Jones, {Teresa L Z} and Whady Hueb and Jos{\'e} Ramires and Neuza Lopes and Wajchenberg, {Bernardo L{\'e}o} and Martinez, {Eulogio E.} and Oliveira, {Sergio A.} and Ribeiro, {Expedito E.} and Marcos Perin and Roberto Betti and Leonard Schwartz and George Steiner and Alan Barolet and Yolanda Groenewoud and Lisa Mighton and Kathy Camelon and Robert O'Rourke and Janet Blodgett and Edward Sako and Judith Nicastro and Robin Prescott and Charanjit Rihal and Frank Kennedy and Gregory Barsness and Amanda Basu and Alfredo Clavell and Robert Frye and Holmes, {David R.} and Amir Lerman and Charles Mullaney and Guy Reeder and Robert Rizza and Hartzell Schaff and Steven Smith and Virend Somers and Thoralf Sundt and Henry Ting and Wright, {R. Scott} and Pam Helgemoe and Diane Lesmeister and Deborah Rolbiecki and Luis Lepe-Montoya and Jorge Escobedo and Rafael Barraza and Rub{\'e}n Bale{\'o}n and Arturo Campos and Paula Garc{\'i}a and Carlos Lezama and Carlos Miramontes and Salvador Ocampo and Pe{\~n}afiel, {Joaqu{\'i}n V.} and Aquiles Valdespino and Ra{\'u}l Verd{\'i}n and H{\'e}ctor Albarr{\'a}n and Fernando Ayala and Eduardo Ch{\'a}vez and H{\'e}ctor Murillo and Buitr{\'o}n, {Luisa Virginia} and Beatriz Rico-Verdin and Fabiola Angulo and Dale Adler and Halle, {Austin Arthur} and Faramarz Ismail-Beigi and Suvinay Paranjape and Stacey Mazzurco and Karen Ridley and Kodangudi Ramanathan and Solomon Solomon and Barry Wall and Darryl Weinman and Tammy Touchstone and Lillie Douglas and Martial Bourassa and Tardif, {Jean Claude} and Chiasson, {Jean Louis} and Lavoie, {Marc Andre} and R{\'e}mi Rabasa-Lhoret and H{\'e}l{\`e}ne Langelier and Suzy Foucher and Johanne Trudel and Scott Monrad and Vankeepuram Srinivas and Joel Zonszein and Jill Crandall and Helena Duffy and Eugen Vartolomei and Spencer King and Carl Jacobs and David Robertson and Marty Porter and Melanie Eley and Emmalee Nichols and Jennifer LaCorte and Melinda Mock and William Rogers and Fernando Ovalle and David Bell and Misra, {Vijay K.} and Hillegass, {William B.} and Raed Aqel and Penny Pierce and Melanie Smith and Leah Saag and Ashley Vaughn and Dwight Smith and Tiffany Grimes and Susan Rolli and Roberta Hill and Barrett, {Beth Dean} and Clarinda Morehead and Ken Doss and Davidson, {Charles J.} and Mark Molitch and Nirat Beohar and Elaine Massaro and Lynne Goodreau and Fabiola Arroyo and Petr Neužil and Lenka Pavlickova and Štĕp{\'a}nka Stehl{\'i}kov{\'a} and Jaroslav Benedik and Liz Coling and Richard Davies and Christopher Glover and Michel LeMay and Thierry Mesana and Ooi, {Teik Chye} and Mark Silverman and Alexander Sorisky and Colette Favreau and Susan McClinton and Melvin Weiss and Irene Weiss and Leo Saulle and Harichandra Kannam and Kurylas, {Joanne C.} and Lorraine Vasi and John Douglas and Ziyad Ghazzal and Laurence Sperling and Spencer King and Priya Dayamani and Suzanne Gebhart and Sabreena Basu and Tarek Helmy and Vin Tangpricha and Pamela Hyde and Margaret Jenkins and Grant, {Barbara P.} and Kenneth Kent and William Suddath and Michelle Magee and Patricia Julien-Williams and Vida Reed and Carine Nassar and Gilles Dagenais and Claude Garceau and Dominique Auger and Christopher Buller and Tom Elliott and Krishnan Ramanathan and Donald Ricci and Rebecca Fox and Daniela Kolesniak and Michael Attubato and Frederick Feit and Stephen Richardson and Sing, {Ivan Pena} and James Slater and Angela Amendola and Bernardo Vargas and Nicholas Tsapatsaris and Bartholomew Woods and Gary Cushing and Martin Rutter and Premranjan Singh and Gail DesRochers and Gail Woodhead and Deborah Gannon and Campbell, {Nancy Shinopulos} and Michael Ragosta and Ian Sarembock and Eric Powers and Eugene Barrett and Linda Jahn and Karen Murie and Gladwin Das and Gardar Sigurdsson and Carl White and John Bantle and Redmon, {J. Bruce} and Christine Kwong and Jacqueline Tamis-Holland and Jeanine Albu and Hochman, {Judith S.} and James Slater and James Wilentz and Sylvaine Frances and Deborah Tormey and Carl Pepine and Karen Smith and Laurence Kennedy and Karen Brezner and Tempa Curry and Frank Bleyer and Stewart Albert and Arshag Mooradian and Sharon Plummer and Francisco Fuentes and Roberto Robles and Victor Lavis and Jaime Gomez and Cesar Iliescu and Carol Underwood and Fulton, {Maria Selin} and Ramirez, {Julie Gomez} and Jennifer Merta and Glenna Scott and Ashok Krishnaswami and Lynn Dowdell and Sarah Berkheimer and Adam Greenbaum and Fred Whitehouse and Raquel Pangilinan and Kelly Mann and Jacobs, {Alice K.} and Elliot Sternthal and Susana Ebner and Zoran Nedeljkovic and Paula Beardsley and David Schneider and Richard Pratley and William Cefalu and Joel Schnure and Michaelanne Rowen and Linda Tilton and Alan Niederman and Cristina Mata and Terri Kellerman and John Farmer and Garber, {Alan J.} and Neal Kleiman and Nancy Howard and Debra Nichols and Madonna Pool and Donner, {Thomas W} and Mark Feinglos and George Adams and Jennifer Green and Bernadette Druken and Dani Underwood and Stafford, {J. Lawrence} and Thomas Donner and Warren Laskey and Dana Beach and John Lopez and Andrew Davis and David Faxon and Sirimon Reutrakul and Emily Bayer and Oscar Marroquin and Howard Cohen and Mary Korytkowski and Glory Koerbel and Lisa Baxendell and Debbie Rosenfelder and Louise DeRiso and Carole Farrell and Tina Vita and Janet McGill and Ronald Krone and Richard Bach and Carol Recklein and Luepke, {Kristin M.} and Clifton, {Mary Jane} and Farkouh, {Michael E.} and Kim, {Michael C.} and Smith, {Donald A.} and Ida Guzman and Arlene Travis and James O'Keefe and Alan Forker and William Isley and Richard Moe and Paul Kennedy and Margaret Rosson and Aimee Long and Sheldon Gottlieb and Annabelle Rodriguez-Oquendo and Rodica Pop-Busui and Claire Duvernoy and Martin Stevens and Ann Luciano and Cheryl Majors and Gottlieb, {Sheldon H.} and Annabelle Rodriguez and Melanie Herr and David Williams and Smith, {Robert J.} and Abbott, {J. Dawn} and Laufgraben, {Marc J.} and Mary Grogan and Janice Muratori and Gabriel Habib and Marco Marcelli and Issam Mikati and Emilia Cordero and Gina Caldwell and David Schechter and Daniel Lorber and Phyllis August and Maisie Brown and Patricia Depree and Kurt Huber and Ursula Hanusch-Enserer and Nelly Jordanova and Dilek Cilesiz and Birgit Vogel and Ben McCallister and Michael Kleerekoper and Kelly Mandagere and Robert Urbanic and James Bengston and Kong, {Bobby K.} and Andrew Pruitt and Jeffrey Sanfield and Carol Carulli and Ruth Churley-Strom and Raymond Magorien and Kwame Osei and Boyer, {Cecilia Casey} and Richard Lee and Pasquale Palumbo and Joyce Wisbey and Edwin Alderman and Fumiaki Ikeno and {Michael Steffes}, {Anne Schwarzkopf} and Maren Nowicki and Jean Bucksa and Bernard Chaitman and Jane Eckstein and Karen Stocke and Hlatky, {Mark A.} and Boothroyd, {Derek B.} and Melsop, {Kathryn A.} and Sobel, {Burton E.} and Michaelanne Rowen and Dagnija Neimane and Iskandrian, {Ami E.} and Schaaf, {Mary Beth} and Saul Genuth and Theresa Bongarno and Richard Nesto and Phyllis August and Karen Hultberg and Gottlieb, {Sheldon H.} and Jeanine Albu and Helene Rosenhouse-Romeo and Orchard, {Trevor J.} and Georgia Pambianco and Manuel Lombardero and Michael Mock and Frye, {Robert L.} and Brooks, {Maria Mori} and Patrice Desvigne-Nickens and Abby Ershow and Saul Genuth and Suzanne Goldberg and David Gordon and Regina Hardison and Jones, {Teresa L Z} and Sheryl Kelsey and Richard Nesto and Trevor Orchard and Dina Paltoo and Yves Rosenberg and Thomas Ryan and Harold Lebovitz and Robert Brown and Gottlieb Friesinger and Edward Horton and Jay Mason and Renu Virmani and Lawrence Wechsler and Bairey-Merz, {C. Noel} and Kennedy, {J. Ward} and David Gordon and Elliott Antman and John Colwell and Sarah Fowler and Curt Furberg and Lee Goldman and Bruce Jennings and Scott Rankin",
year = "2017",
month = "1",
day = "31",
doi = "10.1016/j.jacc.2016.10.067",
language = "English (US)",
volume = "69",
pages = "395--403",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - SYNTAX Score and Long-Term Outcomes

T2 - The BARI-2D Trial

AU - Ikeno, Fumiaki

AU - Brooks, Maria Mori

AU - Nakagawa, Kaori

AU - Kim, Min Kyu

AU - Kaneda, Hideaki

AU - Mitsutake, Yoshiaki

AU - Vlachos, Helen A.

AU - Schwartz, Leonard

AU - Frye, Robert L.

AU - Kelsey, Sheryl F.

AU - Waseda, Katsuhisa

AU - Hlatky, Mark A.

AU - Detre, Katherine M.

AU - Kelsey, Sheryl F.

AU - Brooks, Maria Mori

AU - Orchard, Trevor J.

AU - Thomas, Stephen B.

AU - Tyrrell, Kim Sutton

AU - Rana, Jamal S.

AU - Averbach, Frani

AU - MacGregor, Joan M.

AU - O'Neal, Scott M.

AU - Pitluga, Kathleen

AU - Sansing, Veronica

AU - Tranchine, Mary

AU - Crow, Sharon W.

AU - Bertolet, Marianne (Marnie)

AU - Hardison, Regina

AU - Kip, Kevin

AU - Lombardero, Manuel

AU - Lu, Jiang

AU - Janiszewski, Sue

AU - Protivnak, Darina

AU - Reiser, Sarah

AU - Barton, Stephen

AU - Guo, Ping

AU - Kushner, Yulia

AU - Michael, Owen

AU - Martin, Jeffrey P.

AU - Kania, Christopher

AU - Kania, Michael

AU - O'Donnell, Jeffrey

AU - Maxwell, Rae Ann

AU - Frye, Robert L.

AU - Goldberg, Suzanne

AU - Rosenberg, Yves

AU - Desvigne-Nickens, Patrice

AU - Ershow, Abby

AU - Gordon, David

AU - Paltoo, Dina

AU - Jones, Teresa L Z

AU - Hueb, Whady

AU - Ramires, José

AU - Lopes, Neuza

AU - Wajchenberg, Bernardo Léo

AU - Martinez, Eulogio E.

AU - Oliveira, Sergio A.

AU - Ribeiro, Expedito E.

AU - Perin, Marcos

AU - Betti, Roberto

AU - Schwartz, Leonard

AU - Steiner, George

AU - Barolet, Alan

AU - Groenewoud, Yolanda

AU - Mighton, Lisa

AU - Camelon, Kathy

AU - O'Rourke, Robert

AU - Blodgett, Janet

AU - Sako, Edward

AU - Nicastro, Judith

AU - Prescott, Robin

AU - Rihal, Charanjit

AU - Kennedy, Frank

AU - Barsness, Gregory

AU - Basu, Amanda

AU - Clavell, Alfredo

AU - Frye, Robert

AU - Holmes, David R.

AU - Lerman, Amir

AU - Mullaney, Charles

AU - Reeder, Guy

AU - Rizza, Robert

AU - Schaff, Hartzell

AU - Smith, Steven

AU - Somers, Virend

AU - Sundt, Thoralf

AU - Ting, Henry

AU - Wright, R. Scott

AU - Helgemoe, Pam

AU - Lesmeister, Diane

AU - Rolbiecki, Deborah

AU - Lepe-Montoya, Luis

AU - Escobedo, Jorge

AU - Barraza, Rafael

AU - Baleón, Rubén

AU - Campos, Arturo

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AU - Pambianco, Georgia

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AU - Mock, Michael

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AU - Brooks, Maria Mori

AU - Desvigne-Nickens, Patrice

AU - Ershow, Abby

AU - Genuth, Saul

AU - Goldberg, Suzanne

AU - Gordon, David

AU - Hardison, Regina

AU - Jones, Teresa L Z

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AU - Wechsler, Lawrence

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AU - Kennedy, J. Ward

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AU - Fowler, Sarah

AU - Furberg, Curt

AU - Goldman, Lee

AU - Jennings, Bruce

AU - Rankin, Scott

PY - 2017/1/31

Y1 - 2017/1/31

N2 - Background The extent of coronary disease affects clinical outcomes and may predict the effectiveness of coronary revascularization with either coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI). The SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score quantifies the extent of coronary disease. Objectives This study sought to determine whether SYNTAX scores predicted outcomes and the effectiveness of coronary revascularization compared with medical therapy in the BARI-2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial. Methods Baseline SYNTAX scores were retrospectively calculated for BARI-2D patients without prior revascularization (N = 1,550) by angiographic laboratory investigators masked to patient characteristics and outcomes. The primary outcome was major cardiovascular events (a composite of death, myocardial infarction, and stroke) over 5 years. Results A mid/high SYNTAX score (≥23) was associated with a higher risk of major cardiovascular events (hazard ratio: 1.36, confidence interval: 1.07 to 1.75, p = 0.01). Patients in the CABG stratum had significantly higher SYNTAX scores: 36% had mid/high SYNTAX scores compared with 13% in the PCI stratum (p < 0.001). Among patients with low SYNTAX scores (≤22), major cardiovascular events did not differ significantly between revascularization and medical therapy, either in the CABG stratum (26.1% vs. 29.9%, p = 0.41) or in the PCI stratum (17.8% vs. 19.2%, p = 0.84). Among patients with mid/high SYNTAX scores, however, major cardiovascular events were lower after revascularization than with medical therapy in the CABG stratum (15.3% vs. 30.3%, p = 0.02), but not in the PCI stratum (35.6% vs. 26.5%, p = 0.12). Conclusions Among patients with diabetes and stable ischemic heart disease, higher SYNTAX scores predict higher rates of major cardiovascular events and were associated with more favorable outcomes of revascularization compared with medical therapy among patients suitable for CABG. (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes; NCT00006305)

AB - Background The extent of coronary disease affects clinical outcomes and may predict the effectiveness of coronary revascularization with either coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI). The SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score quantifies the extent of coronary disease. Objectives This study sought to determine whether SYNTAX scores predicted outcomes and the effectiveness of coronary revascularization compared with medical therapy in the BARI-2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial. Methods Baseline SYNTAX scores were retrospectively calculated for BARI-2D patients without prior revascularization (N = 1,550) by angiographic laboratory investigators masked to patient characteristics and outcomes. The primary outcome was major cardiovascular events (a composite of death, myocardial infarction, and stroke) over 5 years. Results A mid/high SYNTAX score (≥23) was associated with a higher risk of major cardiovascular events (hazard ratio: 1.36, confidence interval: 1.07 to 1.75, p = 0.01). Patients in the CABG stratum had significantly higher SYNTAX scores: 36% had mid/high SYNTAX scores compared with 13% in the PCI stratum (p < 0.001). Among patients with low SYNTAX scores (≤22), major cardiovascular events did not differ significantly between revascularization and medical therapy, either in the CABG stratum (26.1% vs. 29.9%, p = 0.41) or in the PCI stratum (17.8% vs. 19.2%, p = 0.84). Among patients with mid/high SYNTAX scores, however, major cardiovascular events were lower after revascularization than with medical therapy in the CABG stratum (15.3% vs. 30.3%, p = 0.02), but not in the PCI stratum (35.6% vs. 26.5%, p = 0.12). Conclusions Among patients with diabetes and stable ischemic heart disease, higher SYNTAX scores predict higher rates of major cardiovascular events and were associated with more favorable outcomes of revascularization compared with medical therapy among patients suitable for CABG. (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes; NCT00006305)

KW - angiography

KW - coronary disease

KW - ischemia

KW - prognosis

KW - stents

KW - surgery

UR - http://www.scopus.com/inward/record.url?scp=85010442916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010442916&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2016.10.067

DO - 10.1016/j.jacc.2016.10.067

M3 - Article

C2 - 28126156

AN - SCOPUS:85010442916

VL - 69

SP - 395

EP - 403

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 4

ER -