Synphilin-1 is present in lewy bodies in Parkinson's disease

Koichi Wakabayashi, Simone Engelender, Makoto Yoshimoto, Shoji Tsuji, Christopher A Ross, Hitoshi Takahashi

Research output: Contribution to journalArticle

Abstract

α-Synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the α-synuclein gene are responsible for familial forms of PD and α-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with α-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.

Original languageEnglish (US)
Pages (from-to)521-523
Number of pages3
JournalAnnals of Neurology
Volume47
Issue number4
DOIs
StatePublished - 2000

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Synucleins
Parkinson Disease
Lewy Bodies
Proteins
Mutation
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

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Synphilin-1 is present in lewy bodies in Parkinson's disease. / Wakabayashi, Koichi; Engelender, Simone; Yoshimoto, Makoto; Tsuji, Shoji; Ross, Christopher A; Takahashi, Hitoshi.

In: Annals of Neurology, Vol. 47, No. 4, 2000, p. 521-523.

Research output: Contribution to journalArticle

Wakabayashi, K, Engelender, S, Yoshimoto, M, Tsuji, S, Ross, CA & Takahashi, H 2000, 'Synphilin-1 is present in lewy bodies in Parkinson's disease', Annals of Neurology, vol. 47, no. 4, pp. 521-523. https://doi.org/10.1002/1531-8249(200004)47:4<521::AID-ANA18>3.0.CO;2-B
Wakabayashi, Koichi ; Engelender, Simone ; Yoshimoto, Makoto ; Tsuji, Shoji ; Ross, Christopher A ; Takahashi, Hitoshi. / Synphilin-1 is present in lewy bodies in Parkinson's disease. In: Annals of Neurology. 2000 ; Vol. 47, No. 4. pp. 521-523.
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