Synopsis of guidelines for the clinical management of cerebral cavernous malformations

Consensus recommendations based on systematic literature review by the angioma alliance scientific advisory board clinical experts panel

Amy Akers, Rustam Al-Shahi Salman, Issam A. Awad, Kristen Dahlem, Kelly Flemming, Blaine Hart, Helen Kim, Ignacio Jusue-Torres, Douglas Kondziolka, Cornelia Lee, Leslie Morrison, Daniele Rigamonti, Tania Rebeiz, Elisabeth Tournier-Lasserve, Darrel Waggoner, Kevin Whitehead, M. Yashar, S. Kalani, Rafael J Tamargo

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Despite many publications about cerebral cavernous malformations (CCMs), controversy remains regarding diagnostic and management strategies. OBJECTIVE: To develop guidelines for CCM management. METHODS: The Angioma Alliance (www.angioma.org), the patient support group in the United States advocating on behalf of patients and research in CCM, convened a multidisciplinary writing group comprising expert CCM clinicians to help summarize the existing literature related to the clinical care of CCM, focusing on 5 topics: (1) epidemiology and natural history, (2) genetic testing and counseling, (3) diagnostic criteria and radiology standards, (4) neurosurgical considerations, and (5) neurological considerations. The group reviewed literature, rated evidence, developed recommendations, and established consensus, controversies, and knowledge gaps according to a prespecified protocol. RESULTS: Of 1270 publications published between January 1, 1983 and September 31, 2014, we selected 98 based on methodological criteria, and identified 38 additional recent or relevant publications. Topic authors used these publications to summarize current knowledge and arrive at 23 consensus management recommendations, which we rated by class (size of effect) and level (estimate of certainty) according to the American Heart Association/American Stroke Association criteria. No recommendation was level A (because of the absence of randomized controlled trials), 11 (48%) were level B, and 12 (52%) were level C. Recommendations were class I in 8 (35%), class II in 10 (43%), and class III in 5 (22%). CONCLUSION: Current evidence supports recommendations for the management of CCM, but their generally low levels and classes mandate further research to better inform clinical practice and update these recommendations. The complete recommendations document, including the criteria for selecting reference citations, a more detailed justification of the respective recommendations, and a summary of controversies and knowledge gaps, was similarly peer reviewed and is available on line www.angioma.org/CCMGuidelines.

Original languageEnglish (US)
Pages (from-to)665-680
Number of pages16
JournalClinical Neurosurgery
Volume80
Issue number5
DOIs
StatePublished - Jan 1 2017

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Central Nervous System Cavernous Hemangioma
Hemangioma
Guidelines
Publications
Self-Help Groups
Genetic Counseling
Genetic Testing
Natural History
Research
Radiology
Epidemiology
Randomized Controlled Trials

Keywords

  • Angioma
  • Cavernous
  • Guidelines
  • Malformation
  • Recommendations

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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Synopsis of guidelines for the clinical management of cerebral cavernous malformations : Consensus recommendations based on systematic literature review by the angioma alliance scientific advisory board clinical experts panel. / Akers, Amy; Al-Shahi Salman, Rustam; Awad, Issam A.; Dahlem, Kristen; Flemming, Kelly; Hart, Blaine; Kim, Helen; Jusue-Torres, Ignacio; Kondziolka, Douglas; Lee, Cornelia; Morrison, Leslie; Rigamonti, Daniele; Rebeiz, Tania; Tournier-Lasserve, Elisabeth; Waggoner, Darrel; Whitehead, Kevin; Yashar, M.; Kalani, S.; Tamargo, Rafael J.

In: Clinical Neurosurgery, Vol. 80, No. 5, 01.01.2017, p. 665-680.

Research output: Contribution to journalArticle

Akers, A, Al-Shahi Salman, R, Awad, IA, Dahlem, K, Flemming, K, Hart, B, Kim, H, Jusue-Torres, I, Kondziolka, D, Lee, C, Morrison, L, Rigamonti, D, Rebeiz, T, Tournier-Lasserve, E, Waggoner, D, Whitehead, K, Yashar, M, Kalani, S & Tamargo, RJ 2017, 'Synopsis of guidelines for the clinical management of cerebral cavernous malformations: Consensus recommendations based on systematic literature review by the angioma alliance scientific advisory board clinical experts panel', Clinical Neurosurgery, vol. 80, no. 5, pp. 665-680. https://doi.org/10.1093/neuros/nyx091
Akers, Amy ; Al-Shahi Salman, Rustam ; Awad, Issam A. ; Dahlem, Kristen ; Flemming, Kelly ; Hart, Blaine ; Kim, Helen ; Jusue-Torres, Ignacio ; Kondziolka, Douglas ; Lee, Cornelia ; Morrison, Leslie ; Rigamonti, Daniele ; Rebeiz, Tania ; Tournier-Lasserve, Elisabeth ; Waggoner, Darrel ; Whitehead, Kevin ; Yashar, M. ; Kalani, S. ; Tamargo, Rafael J. / Synopsis of guidelines for the clinical management of cerebral cavernous malformations : Consensus recommendations based on systematic literature review by the angioma alliance scientific advisory board clinical experts panel. In: Clinical Neurosurgery. 2017 ; Vol. 80, No. 5. pp. 665-680.
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abstract = "BACKGROUND: Despite many publications about cerebral cavernous malformations (CCMs), controversy remains regarding diagnostic and management strategies. OBJECTIVE: To develop guidelines for CCM management. METHODS: The Angioma Alliance (www.angioma.org), the patient support group in the United States advocating on behalf of patients and research in CCM, convened a multidisciplinary writing group comprising expert CCM clinicians to help summarize the existing literature related to the clinical care of CCM, focusing on 5 topics: (1) epidemiology and natural history, (2) genetic testing and counseling, (3) diagnostic criteria and radiology standards, (4) neurosurgical considerations, and (5) neurological considerations. The group reviewed literature, rated evidence, developed recommendations, and established consensus, controversies, and knowledge gaps according to a prespecified protocol. RESULTS: Of 1270 publications published between January 1, 1983 and September 31, 2014, we selected 98 based on methodological criteria, and identified 38 additional recent or relevant publications. Topic authors used these publications to summarize current knowledge and arrive at 23 consensus management recommendations, which we rated by class (size of effect) and level (estimate of certainty) according to the American Heart Association/American Stroke Association criteria. No recommendation was level A (because of the absence of randomized controlled trials), 11 (48{\%}) were level B, and 12 (52{\%}) were level C. Recommendations were class I in 8 (35{\%}), class II in 10 (43{\%}), and class III in 5 (22{\%}). CONCLUSION: Current evidence supports recommendations for the management of CCM, but their generally low levels and classes mandate further research to better inform clinical practice and update these recommendations. The complete recommendations document, including the criteria for selecting reference citations, a more detailed justification of the respective recommendations, and a summary of controversies and knowledge gaps, was similarly peer reviewed and is available on line www.angioma.org/CCMGuidelines.",
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AU - Awad, Issam A.

AU - Dahlem, Kristen

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AU - Hart, Blaine

AU - Kim, Helen

AU - Jusue-Torres, Ignacio

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AU - Lee, Cornelia

AU - Morrison, Leslie

AU - Rigamonti, Daniele

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AU - Tournier-Lasserve, Elisabeth

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N2 - BACKGROUND: Despite many publications about cerebral cavernous malformations (CCMs), controversy remains regarding diagnostic and management strategies. OBJECTIVE: To develop guidelines for CCM management. METHODS: The Angioma Alliance (www.angioma.org), the patient support group in the United States advocating on behalf of patients and research in CCM, convened a multidisciplinary writing group comprising expert CCM clinicians to help summarize the existing literature related to the clinical care of CCM, focusing on 5 topics: (1) epidemiology and natural history, (2) genetic testing and counseling, (3) diagnostic criteria and radiology standards, (4) neurosurgical considerations, and (5) neurological considerations. The group reviewed literature, rated evidence, developed recommendations, and established consensus, controversies, and knowledge gaps according to a prespecified protocol. RESULTS: Of 1270 publications published between January 1, 1983 and September 31, 2014, we selected 98 based on methodological criteria, and identified 38 additional recent or relevant publications. Topic authors used these publications to summarize current knowledge and arrive at 23 consensus management recommendations, which we rated by class (size of effect) and level (estimate of certainty) according to the American Heart Association/American Stroke Association criteria. No recommendation was level A (because of the absence of randomized controlled trials), 11 (48%) were level B, and 12 (52%) were level C. Recommendations were class I in 8 (35%), class II in 10 (43%), and class III in 5 (22%). CONCLUSION: Current evidence supports recommendations for the management of CCM, but their generally low levels and classes mandate further research to better inform clinical practice and update these recommendations. The complete recommendations document, including the criteria for selecting reference citations, a more detailed justification of the respective recommendations, and a summary of controversies and knowledge gaps, was similarly peer reviewed and is available on line www.angioma.org/CCMGuidelines.

AB - BACKGROUND: Despite many publications about cerebral cavernous malformations (CCMs), controversy remains regarding diagnostic and management strategies. OBJECTIVE: To develop guidelines for CCM management. METHODS: The Angioma Alliance (www.angioma.org), the patient support group in the United States advocating on behalf of patients and research in CCM, convened a multidisciplinary writing group comprising expert CCM clinicians to help summarize the existing literature related to the clinical care of CCM, focusing on 5 topics: (1) epidemiology and natural history, (2) genetic testing and counseling, (3) diagnostic criteria and radiology standards, (4) neurosurgical considerations, and (5) neurological considerations. The group reviewed literature, rated evidence, developed recommendations, and established consensus, controversies, and knowledge gaps according to a prespecified protocol. RESULTS: Of 1270 publications published between January 1, 1983 and September 31, 2014, we selected 98 based on methodological criteria, and identified 38 additional recent or relevant publications. Topic authors used these publications to summarize current knowledge and arrive at 23 consensus management recommendations, which we rated by class (size of effect) and level (estimate of certainty) according to the American Heart Association/American Stroke Association criteria. No recommendation was level A (because of the absence of randomized controlled trials), 11 (48%) were level B, and 12 (52%) were level C. Recommendations were class I in 8 (35%), class II in 10 (43%), and class III in 5 (22%). CONCLUSION: Current evidence supports recommendations for the management of CCM, but their generally low levels and classes mandate further research to better inform clinical practice and update these recommendations. The complete recommendations document, including the criteria for selecting reference citations, a more detailed justification of the respective recommendations, and a summary of controversies and knowledge gaps, was similarly peer reviewed and is available on line www.angioma.org/CCMGuidelines.

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