Synergistic Coordination of Chromatin Torsional Mechanics and Topoisomerase Activity

Tung T. Le, Xiang Gao, Seong ha Park, Jaeyoon Lee, James T. Inman, Joyce H. Lee, Jessica L. Killian, Ryan P. Badman, James M. Berger, Michelle D. Wang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The material properties of eukaryotic chromatin fibers partition supercoiling ahead of progressing replication forks, illustrating that chromatin provides a buffer against torsional stress and that its unique mechanical properties help to facilitate replication and minimize genome instability.

Original languageEnglish (US)
Pages (from-to)619-631.e15
Issue number3
StatePublished - Oct 17 2019


  • DNA supercoiling
  • angular optical trap
  • braiding
  • chromatin
  • fork rotation
  • magnetic tweezers
  • replication
  • topoisomerase
  • torque
  • torsional modulus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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