Synergistic Coordination of Chromatin Torsional Mechanics and Topoisomerase Activity

Tung T. Le, Xiang Gao, Seong ha Park, Jaeyoon Lee, James T. Inman, Joyce H. Lee, Jessica L. Killian, Ryan P. Badman, James M. Berger, Michelle D. Wang

Research output: Contribution to journalArticlepeer-review

Abstract

The material properties of eukaryotic chromatin fibers partition supercoiling ahead of progressing replication forks, illustrating that chromatin provides a buffer against torsional stress and that its unique mechanical properties help to facilitate replication and minimize genome instability.

Original languageEnglish (US)
Pages (from-to)619-631.e15
JournalCell
Volume179
Issue number3
DOIs
StatePublished - Oct 17 2019

Keywords

  • DNA supercoiling
  • angular optical trap
  • braiding
  • chromatin
  • fork rotation
  • magnetic tweezers
  • replication
  • topoisomerase
  • torque
  • torsional modulus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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