Synergistic antibacterial effect between silybin and N,N'- dicyclohexylcarbodiimide in clinical Pseudomonas aeruginosa isolates

Hyun Jun Jung, Dong Gun Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Silybin is a composition of the silymarin group as a hepatoprotective agent, and it exhibits various biological activities, including an antibacterial activity. In this study, the effects of a combination of silybin with N,N'-dicyclohexylcarbodiimide (DCCD) against clinical isolates of Pseudomonas aeruginosa were investigated. In the results of susceptibility assay, silybin showed more potent antibacterial activity in methicilin-resistant Staphylococcus aureus (MRSA) than in P. aeruginosa, but DCCD significantly increased the antibacterial activity of silybin in P. aeruginosa. The antibacterial activity of silybin was affected by the strong action of multidrug-resistant pumps rather than by a permeable disruption of lipopolysaccharide and silybin showed a remarkable synergistic activity in combination with some antibiotic agents against drug-resistant bacteria. Therefore, silybin has a potential as a combination therapeutic agent for treatment of infectious diseases by multidrug-resistant bacteria.

Original languageEnglish (US)
Pages (from-to)462-467
Number of pages6
JournalJournal of Microbiology
Volume46
Issue number4
DOIs
StatePublished - Aug 2008
Externally publishedYes

Keywords

  • Antibacterial activity
  • MDR pump
  • N,N'-dicyclohexylcarbodiimide
  • Silybin
  • Synergistic effect

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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