Synergistic anti-pneumocystis carinii effects of erythromycin and sulfisoxazole

Walter T. Hughes, John T. Killmar

Research output: Contribution to journalArticle

Abstract

Pneumocystis carinii pneumonitis was effectively prevented in 90% of immunosuppressed rats by the administration of 100 mg of erythromycin and 300 mg/kg/day of sulfisoxazole. All of the untreated control and erythromycintreated animals developed the infection and 80% of rats given sulfisoxazole alone had the pneumonitis. A similar pattern of response occurred when the drugs were used therapeutically for rats with established P. carinii pneumonitis. The erythromycin and sulfisoxazole ratio of 1:3 was the most effective of several dose combinations tested. The established safety record from three decades of clinical use of this drug combination plus the broad spectrum of coverage for other causes of diffuse pneumonitis such as Chlamydia, Mycoplasma, and Legionella warrant further study of erythromycin-sulfisoxazole in AIDS patients.

Original languageEnglish (US)
Pages (from-to)532-537
Number of pages6
JournalJournal of acquired immune deficiency syndromes
Volume4
Issue number5
StatePublished - May 1991

Keywords

  • Erythromycin
  • Pneumocystis carinii
  • Pneumonitis
  • Sulfisoxazole

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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