Synergism of combined lithium-neuroleptic therapy: A double-blind, placebo-controlled case study

L. B. Bigelow, D. R. Weinberger, R. J. Wyatt

Research output: Contribution to journalArticlepeer-review

Abstract

The authors describe a longitudinal, placebo-controlled study of the response to drug treatment of a 62-year-old schizoaffective patient hospitalized for 40 years. While neither lithium nor a neuroleptic drug alone was effective, both drugs administered simultaneously led to the gradual extinction of a pronounced behavioral cycle and the disappearance of manifest psychosis. The authors suggest a synergistic interaction between the two drugs and stress the need for sustained trials of the combination in patients with similar behavioral cycles.

Original languageEnglish (US)
Pages (from-to)81-83
Number of pages3
JournalAmerican Journal of Psychiatry
Volume138
Issue number1
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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