Synergism of CAY-1 with amphotericin B and itraconazole

A. J. De Lucca, J. M. Bland, S. Boue, C. B. Vigo, T. E. Cleveland, T. J. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

Background: CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT. Methods: CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixed with nongerminated (NG) and germinating (G) conidia of three Aspergillus species and Candida albicans. Inhibition was visually determined at 24 and 48 h. Results: CAY-1 had predominantly additive-synergistic interaction with AB or IT against the Aspergillus NG and G conidia. Excellent synergy between CAY-1 and AB occurred at 24 and 48 h against C. albicans. Results suggest CAY-1 enhances AB and IT efficacy.

Original languageEnglish (US)
Pages (from-to)285-287
Number of pages3
JournalCHEMOTHERAPY
Volume52
Issue number6
DOIs
StatePublished - Oct 2006

Keywords

  • Additive-synergistic effect
  • Amphotericin B
  • Itraconazole
  • Saponin
  • Synergism

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

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