Synergism of CAY-1 with amphotericin B and itraconazole

A. J. De Lucca; J. M. Bland; S. Boue; C. B. Vigo; T. E. Cleveland; T. J. Walsh

doi:10.1159/000095959

Synergism of CAY-1 with amphotericin B and itraconazole

A. J. De Lucca, J. M. Bland, S. Boue, C. B. Vigo, T. E. Cleveland, T. J. Walsh

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT. Methods: CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixed with nongerminated (NG) and germinating (G) conidia of three Aspergillus species and Candida albicans. Inhibition was visually determined at 24 and 48 h. Results: CAY-1 had predominantly additive-synergistic interaction with AB or IT against the Aspergillus NG and G conidia. Excellent synergy between CAY-1 and AB occurred at 24 and 48 h against C. albicans. Results suggest CAY-1 enhances AB and IT efficacy.

Original language	English (US)
Pages (from-to)	285-287
Number of pages	3
Journal	CHEMOTHERAPY
Volume	52
Issue number	6
DOIs	https://doi.org/10.1159/000095959
State	Published - Oct 2006
Externally published	Yes

Keywords

Additive-synergistic effect
Amphotericin B
Itraconazole
Saponin
Synergism

ASJC Scopus subject areas

Oncology
Pharmacology
Drug Discovery
Pharmacology (medical)
Infectious Diseases

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10.1159/000095959

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title = "Synergism of CAY-1 with amphotericin B and itraconazole",

abstract = "Background: CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT. Methods: CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixed with nongerminated (NG) and germinating (G) conidia of three Aspergillus species and Candida albicans. Inhibition was visually determined at 24 and 48 h. Results: CAY-1 had predominantly additive-synergistic interaction with AB or IT against the Aspergillus NG and G conidia. Excellent synergy between CAY-1 and AB occurred at 24 and 48 h against C. albicans. Results suggest CAY-1 enhances AB and IT efficacy.",

keywords = "Additive-synergistic effect, Amphotericin B, Itraconazole, Saponin, Synergism",

author = "{De Lucca}, {A. J.} and Bland, {J. M.} and S. Boue and Vigo, {C. B.} and Cleveland, {T. E.} and Walsh, {T. J.}",

year = "2006",

month = oct,

doi = "10.1159/000095959",

language = "English (US)",

volume = "52",

pages = "285--287",

journal = "CHEMOTHERAPY",

issn = "0009-3157",

publisher = "S. Karger AG",

number = "6",

}

TY - JOUR

T1 - Synergism of CAY-1 with amphotericin B and itraconazole

AU - De Lucca, A. J.

AU - Bland, J. M.

AU - Boue, S.

AU - Vigo, C. B.

AU - Cleveland, T. E.

AU - Walsh, T. J.

PY - 2006/10

Y1 - 2006/10

N2 - Background: CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT. Methods: CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixed with nongerminated (NG) and germinating (G) conidia of three Aspergillus species and Candida albicans. Inhibition was visually determined at 24 and 48 h. Results: CAY-1 had predominantly additive-synergistic interaction with AB or IT against the Aspergillus NG and G conidia. Excellent synergy between CAY-1 and AB occurred at 24 and 48 h against C. albicans. Results suggest CAY-1 enhances AB and IT efficacy.

AB - Background: CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT. Methods: CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixed with nongerminated (NG) and germinating (G) conidia of three Aspergillus species and Candida albicans. Inhibition was visually determined at 24 and 48 h. Results: CAY-1 had predominantly additive-synergistic interaction with AB or IT against the Aspergillus NG and G conidia. Excellent synergy between CAY-1 and AB occurred at 24 and 48 h against C. albicans. Results suggest CAY-1 enhances AB and IT efficacy.

KW - Additive-synergistic effect

KW - Amphotericin B

KW - Itraconazole

KW - Saponin

KW - Synergism

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DO - 10.1159/000095959

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JO - CHEMOTHERAPY

JF - CHEMOTHERAPY

IS - 6

ER -

Synergism of CAY-1 with amphotericin B and itraconazole

Abstract

Keywords

ASJC Scopus subject areas

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