Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder

Mohammad H. Rahbar, Maureen Samms-Vaughan, Jianzhong Ma, Jan Bressler, Aisha Dickerson, Manouchehr Hessabi, Katherine A. Loveland, Megan L. Grove, Sydonnie Shakespeare-Pellington, Compton Beecher, Wayne McLaughlin, Eric Boerwinkle

Research output: Contribution to journalArticle

Abstract

Abstract We used data from 100 age- and sex-matched case-control pairs (age 2-8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ≥ 12 μg/L had about 4 times higher odds of ASD than those with BMC < 12 μg/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ≥ 12 μg/L had about six times higher odds of ASD than those with BMC < 12 μg/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted.

Original languageEnglish (US)
Article number1069
Pages (from-to)73-82
Number of pages10
JournalResearch in Autism Spectrum Disorders
Volume18
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Fingerprint

Manganese
Genetic Models
Genotype
Glutathione S-Transferase pi
Jamaica
Glutathione Transferase
Autism Spectrum Disorder
Population
Genes

Keywords

  • Autism Spectrum Disorder (ASD)
  • Glutathione-S-transferase (GST) genes
  • Interactions
  • Jamaica
  • Manganese
  • Oxidative stress

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder. / Rahbar, Mohammad H.; Samms-Vaughan, Maureen; Ma, Jianzhong; Bressler, Jan; Dickerson, Aisha; Hessabi, Manouchehr; Loveland, Katherine A.; Grove, Megan L.; Shakespeare-Pellington, Sydonnie; Beecher, Compton; McLaughlin, Wayne; Boerwinkle, Eric.

In: Research in Autism Spectrum Disorders, Vol. 18, 1069, 01.10.2015, p. 73-82.

Research output: Contribution to journalArticle

Rahbar, MH, Samms-Vaughan, M, Ma, J, Bressler, J, Dickerson, A, Hessabi, M, Loveland, KA, Grove, ML, Shakespeare-Pellington, S, Beecher, C, McLaughlin, W & Boerwinkle, E 2015, 'Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder', Research in Autism Spectrum Disorders, vol. 18, 1069, pp. 73-82. https://doi.org/10.1016/j.rasd.2015.08.001
Rahbar, Mohammad H. ; Samms-Vaughan, Maureen ; Ma, Jianzhong ; Bressler, Jan ; Dickerson, Aisha ; Hessabi, Manouchehr ; Loveland, Katherine A. ; Grove, Megan L. ; Shakespeare-Pellington, Sydonnie ; Beecher, Compton ; McLaughlin, Wayne ; Boerwinkle, Eric. / Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder. In: Research in Autism Spectrum Disorders. 2015 ; Vol. 18. pp. 73-82.
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