Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder

Mohammad H. Rahbar, Maureen Samms-Vaughan, Jianzhong Ma, Jan Bressler, Aisha S. Dickerson, Manouchehr Hessabi, Katherine A. Loveland, Megan L. Grove, Sydonnie Shakespeare-Pellington, Compton Beecher, Wayne McLaughlin, Eric Boerwinkle

Research output: Contribution to journalArticle

Abstract

Abstract We used data from 100 age- and sex-matched case-control pairs (age 2-8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ≥ 12 μg/L had about 4 times higher odds of ASD than those with BMC < 12 μg/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ≥ 12 μg/L had about six times higher odds of ASD than those with BMC < 12 μg/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted.

Original languageEnglish (US)
Article number1069
Pages (from-to)73-82
Number of pages10
JournalResearch in Autism Spectrum Disorders
Volume18
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Keywords

  • Autism Spectrum Disorder (ASD)
  • Glutathione-S-transferase (GST) genes
  • Interactions
  • Jamaica
  • Manganese
  • Oxidative stress

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology
  • Psychiatry and Mental health

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  • Cite this

    Rahbar, M. H., Samms-Vaughan, M., Ma, J., Bressler, J., Dickerson, A. S., Hessabi, M., Loveland, K. A., Grove, M. L., Shakespeare-Pellington, S., Beecher, C., McLaughlin, W., & Boerwinkle, E. (2015). Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder. Research in Autism Spectrum Disorders, 18, 73-82. [1069]. https://doi.org/10.1016/j.rasd.2015.08.001