TY - JOUR
T1 - Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder
AU - Rahbar, Mohammad H.
AU - Samms-Vaughan, Maureen
AU - Ma, Jianzhong
AU - Bressler, Jan
AU - Dickerson, Aisha S.
AU - Hessabi, Manouchehr
AU - Loveland, Katherine A.
AU - Grove, Megan L.
AU - Shakespeare-Pellington, Sydonnie
AU - Beecher, Compton
AU - McLaughlin, Wayne
AU - Boerwinkle, Eric
N1 - Funding Information:
This research is co-funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institutes of Health Fogarty International Center (NIH-FIC) by a grant (R21HD057808) as well as National Institute of Environmental Health Sciences (NIEHS) by a grant (R01ES022165) awarded to University of Texas Health Science Center at Houston. We also acknowledge the support provided by the Biostatistics/Epidemiology/Research Design (BERD) component of the Center for Clinical and Translational Sciences (CCTS) for this project. CCTS is mainly funded by the NIH Centers for Translational Science Award (NIH CTSA) grant (UL1 RR024148), awarded to University of Texas Health Science Center at Houston in 2006 by the National Center for Research Resources (NCRR) and its renewal (UL1 TR000371) by the National Center for Advancing Translational Sciences (NCATS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NICHD or the NIH-FIC or NIEHS or the NCRR or the NCATS. Finally, we acknowledge a special discount received from the Western Psychological Services (WPS) (Torrance, CA) for the purchase of ADOS, ADI-R, and SCQ forms that were used for this study.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Abstract We used data from 100 age- and sex-matched case-control pairs (age 2-8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ≥ 12 μg/L had about 4 times higher odds of ASD than those with BMC < 12 μg/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ≥ 12 μg/L had about six times higher odds of ASD than those with BMC < 12 μg/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted.
AB - Abstract We used data from 100 age- and sex-matched case-control pairs (age 2-8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ≥ 12 μg/L had about 4 times higher odds of ASD than those with BMC < 12 μg/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ≥ 12 μg/L had about six times higher odds of ASD than those with BMC < 12 μg/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted.
KW - Autism Spectrum Disorder (ASD)
KW - Glutathione-S-transferase (GST) genes
KW - Interactions
KW - Jamaica
KW - Manganese
KW - Oxidative stress
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U2 - 10.1016/j.rasd.2015.08.001
DO - 10.1016/j.rasd.2015.08.001
M3 - Article
AN - SCOPUS:84939488361
SN - 1750-9467
VL - 18
SP - 73
EP - 82
JO - Research in Autism Spectrum Disorders
JF - Research in Autism Spectrum Disorders
M1 - 1069
ER -