Synchronous primary perianal Paget's disease and rectal adenocarcinoma: Report of a hitherto undescribed phenomenon

Chanjuan Shi, Pedram Argani

Research output: Contribution to journalArticlepeer-review

Abstract

Perianal Paget's disease is rare. It usually represents intraepidermal extension of an invasive carcinoma from an adjacent internal organ, but some cases represent primary intraepithelial cutaneous apocrine adenocarcinomas. Here, we report a unique case, which we interpret as synchronous primary perianal Paget's disease and lower rectal adenocarcinoma. Immunohistochemical stains demonstrated that the Paget's cells were CK7+/CK20 -/GCDFP+, whereas the rectal adenocarcinoma was CK7 +(variable)/CK20+/GCDFP-. This discordant immunoprofile supported our impression that the Paget's disease in this patient was of cutaneous apocrine origin rather than a pagetoid extension from the patient's nearby rectal adenocarcinoma-to our knowledge a hitherto undocumented occurrence.

Original languageEnglish (US)
Pages (from-to)42-45
Number of pages4
JournalInternational journal of surgical pathology
Volume17
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • Perianal
  • Primary Paget's disease
  • Rectal adenocarcinoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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