TY - JOUR
T1 - Synchronous primary perianal Paget's disease and rectal adenocarcinoma
T2 - Report of a hitherto undescribed phenomenon
AU - Shi, Chanjuan
AU - Argani, Pedram
PY - 2009/2
Y1 - 2009/2
N2 - Perianal Paget's disease is rare. It usually represents intraepidermal extension of an invasive carcinoma from an adjacent internal organ, but some cases represent primary intraepithelial cutaneous apocrine adenocarcinomas. Here, we report a unique case, which we interpret as synchronous primary perianal Paget's disease and lower rectal adenocarcinoma. Immunohistochemical stains demonstrated that the Paget's cells were CK7+/CK20 -/GCDFP+, whereas the rectal adenocarcinoma was CK7 +(variable)/CK20+/GCDFP-. This discordant immunoprofile supported our impression that the Paget's disease in this patient was of cutaneous apocrine origin rather than a pagetoid extension from the patient's nearby rectal adenocarcinoma-to our knowledge a hitherto undocumented occurrence.
AB - Perianal Paget's disease is rare. It usually represents intraepidermal extension of an invasive carcinoma from an adjacent internal organ, but some cases represent primary intraepithelial cutaneous apocrine adenocarcinomas. Here, we report a unique case, which we interpret as synchronous primary perianal Paget's disease and lower rectal adenocarcinoma. Immunohistochemical stains demonstrated that the Paget's cells were CK7+/CK20 -/GCDFP+, whereas the rectal adenocarcinoma was CK7 +(variable)/CK20+/GCDFP-. This discordant immunoprofile supported our impression that the Paget's disease in this patient was of cutaneous apocrine origin rather than a pagetoid extension from the patient's nearby rectal adenocarcinoma-to our knowledge a hitherto undocumented occurrence.
KW - Perianal
KW - Primary Paget's disease
KW - Rectal adenocarcinoma
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U2 - 10.1177/1066896908316069
DO - 10.1177/1066896908316069
M3 - Article
C2 - 18499687
AN - SCOPUS:58349103755
VL - 17
SP - 42
EP - 45
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
SN - 1066-8969
IS - 1
ER -