Abstract
We report the first case of distinct, synchronous serous carcinomas of the adnexa arising in a patient with a family history of breast and ovarian cancer and a germline loss of function mutation in BRCA1. Illustrating an exceedingly rare phenomenon of synchronous high-grade carcinomas with distinct histomorphologic, immunohistochemical and cytogenetic features, the case serves as a point of departure for the discussion of phenotypic patterns of carcinomas arising in BRCA1 mutation carriers. We also review patient management, including the importance of risk-reducing salpingo-oophorectomy in women with deleterious BRCA1 mutations, as well as the potential need for an intraoperative pathologic assessment to find occult, high-grade carcinomas in this setting.
Original language | English (US) |
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Pages (from-to) | 117-122 |
Number of pages | 6 |
Journal | International Journal of Gynecological Pathology |
Volume | 37 |
Issue number | 2 |
DOIs | |
State | Published - 2018 |
Externally published | Yes |
Keywords
- BRCA1
- Breast carcinoma
- Exon 13 duplication
- Ovarian carcinoma
- Serous carcinoma
- Synchronous ovarian carcinoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Obstetrics and Gynecology