Synaptosomes: Different populations storing catecholamines and Gamma-aminobutyric acid in homogenates of rat brain [25]

Leslie L. Iversen, Solomon H. Snyder

Research output: Contribution to journalLetterpeer-review

Abstract

IT is well established that when brain tissue is homogenized large numbers of nerve terminals pinch off to form intact membrane-bound particles known as "synaptosomes". These can be isolated from brain homogenates by density gradient centrifugation1-3. Such particles contain various presumptive transmitter substances such as acetylcholine, noradrenaline (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT)1-3. Knowledge of synaptic organization could be greatly advanced if a differential morphology for nerve terminals using various transmitters could be established. Attempts to separate synaptosomes storing different transmitters, however, have met with only limited success4-6.

Original languageEnglish (US)
Pages (from-to)796-798
Number of pages3
JournalNature
Volume220
Issue number5169
DOIs
StatePublished - Dec 1 1968

ASJC Scopus subject areas

  • General

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