Synaptosomal uptake and release of dopamine in substantia nigra: Effects of γ-aminobutyric acid and substance P

E. K. Silbergeld, J. R. Walters

Research output: Contribution to journalArticlepeer-review

Abstract

Nigral tissue prepared as synaptosomes demonstrates both high and low affinity uptake of [3H]dopamine. Recently accumulated [3H]dopamine is releasable by 35 mM K+. Substance P increases both uptake and release of dopamine by nigral synaptosomes; γ-aminobutyric acid (GABA) inhibits release with no effect on uptake at concentrations less than 10-4 M. In the striatum, substance P inhibits both uptake and release of dopamine. The results support the existence of dopamine-containing terminals in substantia nigra tissue. The differences in response to substance P and GABA found between nigra and striatum may reflect structural differences in dopamine-containing processes in these areas, related to their proposed origin as dend-tritic (substantia nigra) and axonal (striatal) terminals.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalNeuroscience Letters
Volume12
Issue number1
DOIs
StatePublished - Apr 1979
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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