SynaptomeDB: An ontology-based knowledgebase for synaptic genes

Research output: Contribution to journalArticle

Abstract

Motivation: The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking. Results: We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.

Original languageEnglish (US)
Article numberbts040
Pages (from-to)897-899
Number of pages3
JournalBioinformatics
Volume28
Issue number6
DOIs
StatePublished - Mar 1 2012

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

Fingerprint Dive into the research topics of 'SynaptomeDB: An ontology-based knowledgebase for synaptic genes'. Together they form a unique fingerprint.

  • Cite this