Synaptic targeting of glutamate receptors

Michael D. Ehlers, Andrew L. Mammen, Lit Fui Lau, Richard L. Huganir

Research output: Contribution to journalArticlepeer-review

Abstract

The proper targeting and clustering of neurotransmitter receptors at appropriate postsynaptic sites are principal requirements for the formation of functional synapses. Recently, new studies have begun to elucidate the mechanisms underlying the targeting and clustering of glutamate receptors at excitatory synapses in the brain. Members of the SAP90/PSD-95 family of proteins have emerged as potential regulators of glutamate-receptor membrane distribution. Further, targeting motifs within glutamate receptor subunits have been identified. These findings provide important clues in the effort to understand the molecular features of synaptic organization.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume8
Issue number4
DOIs
StatePublished - Aug 1996

ASJC Scopus subject areas

  • Cell Biology

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