TY - JOUR
T1 - Synaptic processes and immune-related pathways implicated in Tourette syndrome
AU - on behalf of the Tourette Association of America International Consortium for Genetics
AU - the Gilles de la Tourette GWAS Replication Initiative
AU - the Tourette International Collaborative Genetics Study
AU - and the Psychiatric Genomics Consortium Tourette Syndrome Working Group
AU - Tsetsos, Fotis
AU - Yu, Dongmei
AU - Sul, Jae Hoon
AU - Huang, Alden Y.
AU - Illmann, Cornelia
AU - Osiecki, Lisa
AU - Darrow, Sabrina M.
AU - Hirschtritt, Matthew E.
AU - Greenberg, Erica
AU - Muller-Vahl, Kirsten R.
AU - Stuhrmann, Manfred
AU - Dion, Yves
AU - Rouleau, Guy A.
AU - Aschauer, Harald Aschauer Harald
AU - Stamenkovic, Mara
AU - Schlögelhofer, Monika
AU - Sandor, Paul
AU - Barr, Cathy L.
AU - Grados, Marco A.
AU - Singer, Harvey S.
AU - Nöthen, Markus M.
AU - Hebebrand, Johannes
AU - Hinney, Anke
AU - King, Robert A.
AU - Fernandez, Thomas V.
AU - Barta, Csaba
AU - Tarnok, Zsanett
AU - Nagy, Peter
AU - Depienne, Christel
AU - Worbe, Yulia
AU - Hartmann, Andreas
AU - Rizzo, Renata
AU - Lyon, Gholson J.
AU - McMahon, William M.
AU - Batterson, James R.
AU - Malaty, Irene A.
AU - Okun, Michael S.
AU - Berlin, Cheston
AU - Woods, Douglas W.
AU - Lee, Paul C.
AU - Jankovic, Joseph
AU - Robertson, Mary M.
AU - Gilbert, Donald L.
AU - Brown, Lawrence W.
AU - Coffey, Barbara J.
AU - Dietrich, Andrea
AU - Hoekstra, Pieter J.
AU - Kuperman, Samuel
AU - Zinner, Samuel H.
AU - Wagner, Michael
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating ligand-gated ion channel signaling, lymphocytic, and cell adhesion and transsynaptic signaling processes. MAGMA analysis further supported the involvement of the cell adhesion and trans-synaptic signaling gene set. The lymphocytic gene set was driven by variants in FLT3, raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pathogenesis. The indications of involvement of ligand-gated ion channel signaling reinforce the role of GABA in TS, while the association of cell adhesion and trans-synaptic signaling gene set provides additional support for the role of adhesion molecules in neuropsychiatric disorders. This study reinforces previous findings but also provides new insights into the neurobiology of TS.
AB - Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating ligand-gated ion channel signaling, lymphocytic, and cell adhesion and transsynaptic signaling processes. MAGMA analysis further supported the involvement of the cell adhesion and trans-synaptic signaling gene set. The lymphocytic gene set was driven by variants in FLT3, raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pathogenesis. The indications of involvement of ligand-gated ion channel signaling reinforce the role of GABA in TS, while the association of cell adhesion and trans-synaptic signaling gene set provides additional support for the role of adhesion molecules in neuropsychiatric disorders. This study reinforces previous findings but also provides new insights into the neurobiology of TS.
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U2 - 10.1038/s41398-020-01082-z
DO - 10.1038/s41398-020-01082-z
M3 - Article
C2 - 33462189
AN - SCOPUS:85099660047
SN - 2158-3188
VL - 11
JO - Translational psychiatry
JF - Translational psychiatry
IS - 1
M1 - 56
ER -