Symptoms of depression and anxiety as unique predictors of pain-related outcomes following burn injury

Robert R. Edwards, Michael T Smith, Brendan Klick, Gina Magyar-Russell, Jennifer Haythornthwaite, Radha Holavanahalli, David R. Patterson, Patricia Blakeney, Dennis Lezotte, Jodi McKibben, James A Fauerbach

Research output: Contribution to journalArticle

Abstract

Background: The adverse consequences of burn injuries include pain and psychological distress, which show bidirectional associations. However, much of the existing research has relied on global measures of distress that do not separate distinct symptoms of anxiety and depression. Purpose: The purpose is to assess the prospective effects of anxiety and depression on pain and functional outcomes following burn injury. Methods: This article describes a 2-year cohort study inpatients hospitalized for serious burn injuries (assessments at discharge and 6-month, 1-year, and 2-year follow-up). Linear mixed effects analyses were conducted to model anxiety and depression's unique longitudinal effects; at each time point, depressive and anxiety symptoms were studied as predictors of subsequent changes in pain, fatigue, and physical function. Results: When studied in separate prediction models, both depression and anxiety were strong prospective predictors of greater pain, more fatigue, and physical dysfunction at the subsequent time point (ps <.01). However, when both were included in a single model to study their unique effects, depressive symptoms (but not anxiety) emerged as a significant predictor of subsequent increases in pain and reductions in physical functioning, whereas anxiety (but not depression) predicted subsequent elevations in fatigue. Conclusions: These findings suggest potentially distinct effects of depression and anxiety and imply that assessment and early treatment of both depressive and anxiety symptoms may help improve a broad range of long-term pain-related outcomes following burn injury.

Original languageEnglish (US)
Pages (from-to)313-322
Number of pages10
JournalAnnals of Behavioral Medicine
Volume34
Issue number3
DOIs
StatePublished - 2007

Fingerprint

Anxiety
Depression
Pain
Wounds and Injuries
Fatigue
Inpatients
Cohort Studies
Psychology
Research

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Symptoms of depression and anxiety as unique predictors of pain-related outcomes following burn injury. / Edwards, Robert R.; Smith, Michael T; Klick, Brendan; Magyar-Russell, Gina; Haythornthwaite, Jennifer; Holavanahalli, Radha; Patterson, David R.; Blakeney, Patricia; Lezotte, Dennis; McKibben, Jodi; Fauerbach, James A.

In: Annals of Behavioral Medicine, Vol. 34, No. 3, 2007, p. 313-322.

Research output: Contribution to journalArticle

Edwards, RR, Smith, MT, Klick, B, Magyar-Russell, G, Haythornthwaite, J, Holavanahalli, R, Patterson, DR, Blakeney, P, Lezotte, D, McKibben, J & Fauerbach, JA 2007, 'Symptoms of depression and anxiety as unique predictors of pain-related outcomes following burn injury', Annals of Behavioral Medicine, vol. 34, no. 3, pp. 313-322. https://doi.org/10.1007/BF02874556
Edwards, Robert R. ; Smith, Michael T ; Klick, Brendan ; Magyar-Russell, Gina ; Haythornthwaite, Jennifer ; Holavanahalli, Radha ; Patterson, David R. ; Blakeney, Patricia ; Lezotte, Dennis ; McKibben, Jodi ; Fauerbach, James A. / Symptoms of depression and anxiety as unique predictors of pain-related outcomes following burn injury. In: Annals of Behavioral Medicine. 2007 ; Vol. 34, No. 3. pp. 313-322.
@article{f74d0a75a370410ea6ec4edce3f7c42f,
title = "Symptoms of depression and anxiety as unique predictors of pain-related outcomes following burn injury",
abstract = "Background: The adverse consequences of burn injuries include pain and psychological distress, which show bidirectional associations. However, much of the existing research has relied on global measures of distress that do not separate distinct symptoms of anxiety and depression. Purpose: The purpose is to assess the prospective effects of anxiety and depression on pain and functional outcomes following burn injury. Methods: This article describes a 2-year cohort study inpatients hospitalized for serious burn injuries (assessments at discharge and 6-month, 1-year, and 2-year follow-up). Linear mixed effects analyses were conducted to model anxiety and depression's unique longitudinal effects; at each time point, depressive and anxiety symptoms were studied as predictors of subsequent changes in pain, fatigue, and physical function. Results: When studied in separate prediction models, both depression and anxiety were strong prospective predictors of greater pain, more fatigue, and physical dysfunction at the subsequent time point (ps <.01). However, when both were included in a single model to study their unique effects, depressive symptoms (but not anxiety) emerged as a significant predictor of subsequent increases in pain and reductions in physical functioning, whereas anxiety (but not depression) predicted subsequent elevations in fatigue. Conclusions: These findings suggest potentially distinct effects of depression and anxiety and imply that assessment and early treatment of both depressive and anxiety symptoms may help improve a broad range of long-term pain-related outcomes following burn injury.",
author = "Edwards, {Robert R.} and Smith, {Michael T} and Brendan Klick and Gina Magyar-Russell and Jennifer Haythornthwaite and Radha Holavanahalli and Patterson, {David R.} and Patricia Blakeney and Dennis Lezotte and Jodi McKibben and Fauerbach, {James A}",
year = "2007",
doi = "10.1007/BF02874556",
language = "English (US)",
volume = "34",
pages = "313--322",
journal = "Annals of Behavioral Medicine",
issn = "0883-6612",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Symptoms of depression and anxiety as unique predictors of pain-related outcomes following burn injury

AU - Edwards, Robert R.

AU - Smith, Michael T

AU - Klick, Brendan

AU - Magyar-Russell, Gina

AU - Haythornthwaite, Jennifer

AU - Holavanahalli, Radha

AU - Patterson, David R.

AU - Blakeney, Patricia

AU - Lezotte, Dennis

AU - McKibben, Jodi

AU - Fauerbach, James A

PY - 2007

Y1 - 2007

N2 - Background: The adverse consequences of burn injuries include pain and psychological distress, which show bidirectional associations. However, much of the existing research has relied on global measures of distress that do not separate distinct symptoms of anxiety and depression. Purpose: The purpose is to assess the prospective effects of anxiety and depression on pain and functional outcomes following burn injury. Methods: This article describes a 2-year cohort study inpatients hospitalized for serious burn injuries (assessments at discharge and 6-month, 1-year, and 2-year follow-up). Linear mixed effects analyses were conducted to model anxiety and depression's unique longitudinal effects; at each time point, depressive and anxiety symptoms were studied as predictors of subsequent changes in pain, fatigue, and physical function. Results: When studied in separate prediction models, both depression and anxiety were strong prospective predictors of greater pain, more fatigue, and physical dysfunction at the subsequent time point (ps <.01). However, when both were included in a single model to study their unique effects, depressive symptoms (but not anxiety) emerged as a significant predictor of subsequent increases in pain and reductions in physical functioning, whereas anxiety (but not depression) predicted subsequent elevations in fatigue. Conclusions: These findings suggest potentially distinct effects of depression and anxiety and imply that assessment and early treatment of both depressive and anxiety symptoms may help improve a broad range of long-term pain-related outcomes following burn injury.

AB - Background: The adverse consequences of burn injuries include pain and psychological distress, which show bidirectional associations. However, much of the existing research has relied on global measures of distress that do not separate distinct symptoms of anxiety and depression. Purpose: The purpose is to assess the prospective effects of anxiety and depression on pain and functional outcomes following burn injury. Methods: This article describes a 2-year cohort study inpatients hospitalized for serious burn injuries (assessments at discharge and 6-month, 1-year, and 2-year follow-up). Linear mixed effects analyses were conducted to model anxiety and depression's unique longitudinal effects; at each time point, depressive and anxiety symptoms were studied as predictors of subsequent changes in pain, fatigue, and physical function. Results: When studied in separate prediction models, both depression and anxiety were strong prospective predictors of greater pain, more fatigue, and physical dysfunction at the subsequent time point (ps <.01). However, when both were included in a single model to study their unique effects, depressive symptoms (but not anxiety) emerged as a significant predictor of subsequent increases in pain and reductions in physical functioning, whereas anxiety (but not depression) predicted subsequent elevations in fatigue. Conclusions: These findings suggest potentially distinct effects of depression and anxiety and imply that assessment and early treatment of both depressive and anxiety symptoms may help improve a broad range of long-term pain-related outcomes following burn injury.

UR - http://www.scopus.com/inward/record.url?scp=37249047438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37249047438&partnerID=8YFLogxK

U2 - 10.1007/BF02874556

DO - 10.1007/BF02874556

M3 - Article

C2 - 18020941

AN - SCOPUS:37249047438

VL - 34

SP - 313

EP - 322

JO - Annals of Behavioral Medicine

JF - Annals of Behavioral Medicine

SN - 0883-6612

IS - 3

ER -