Symptoms associated with menopausal transition and reproductive hormones in midlife women

Ellen W. Freeman, Mary D. Sammel, Hui Lin, Clarisa R. Gracia, Grace W. Pien, Deborah B. Nelson, Li Sheng

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To test the hypothesis that prevalence of women with menopausal symptoms of hot flushes; aches, joint pain, and stiffness; depressed mood; poor sleep; decreased libido; or vaginal dryness increases with progression through the menopausal transition. METHODS: Women in the Penn Ovarian Aging Study were assessed longitudinally for 9 years. Data were obtained from structured interviews, a validated symptom questionnaire, menstrual bleeding dates and early follicular hormone measures (estradiol [E2], follicle-stimulating hormone [FSH], and inhibin b). Menopausal stages were based on menstrual bleeding patterns. Other risk factors included age, race, history of depression, current smoking, body mass index, and perceived stress. Generalized linear regression models for repeated measures were used to estimate associations among the variables with each symptom. RESULTS: The prevalence of hot flushes; aches, joint pain, and stiffness; and depressed mood increased in the menopausal transition. Menopausal stage was associated with hot flushes (P

Original languageEnglish (US)
Pages (from-to)230-240
Number of pages11
JournalObstetrics and Gynecology
Volume110
Issue number2 I
DOIs
StatePublished - Aug 2007
Externally publishedYes

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Arthralgia
Linear Models
Hormones
Hemorrhage
Pain
Libido
Inhibins
Follicle Stimulating Hormone
Estradiol
Sleep
Body Mass Index
Smoking
Interviews
Depression
Surveys and Questionnaires

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Symptoms associated with menopausal transition and reproductive hormones in midlife women. / Freeman, Ellen W.; Sammel, Mary D.; Lin, Hui; Gracia, Clarisa R.; Pien, Grace W.; Nelson, Deborah B.; Sheng, Li.

In: Obstetrics and Gynecology, Vol. 110, No. 2 I, 08.2007, p. 230-240.

Research output: Contribution to journalArticle

Freeman, Ellen W. ; Sammel, Mary D. ; Lin, Hui ; Gracia, Clarisa R. ; Pien, Grace W. ; Nelson, Deborah B. ; Sheng, Li. / Symptoms associated with menopausal transition and reproductive hormones in midlife women. In: Obstetrics and Gynecology. 2007 ; Vol. 110, No. 2 I. pp. 230-240.
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