TY - JOUR
T1 - Symptomatic, familial, perinatal, and social correlates of computerized axial tomography (Cat) changes in schizophrenics and bipolars
AU - Pearlson, Godfrey D.
AU - Garbacz, David J.
AU - Moberg, Paul J.
AU - Ahn, Hyo S.
AU - Depaulo, J. Raymond
PY - 1985/1
Y1 - 1985/1
N2 - Computerized axial tomography (CAT) scans were blindly examined, and lateral ventric-ular-to-brain ratios calculated in 19 schizophrenic and 27 bipolar patients, and in an equal number of individually matched normal controls. Family history, early development, past psychiatric history, and current functioning and symptomatology were analyzed for all patients. Lateral ventricular enlargement on CAT was found in a significant proportion of both patient groups. Patients with such enlargement tended to have greater numbers of negative symptoms and poorer premorbid adjustment, but did not differ regarding family history of psychiatric illness. A subgroup of schizophrenics with presumed early brain damage was identified. This group had more marked ventricular enlargement, a greater number of negative symptoms, and an earlier onset of illness.
AB - Computerized axial tomography (CAT) scans were blindly examined, and lateral ventric-ular-to-brain ratios calculated in 19 schizophrenic and 27 bipolar patients, and in an equal number of individually matched normal controls. Family history, early development, past psychiatric history, and current functioning and symptomatology were analyzed for all patients. Lateral ventricular enlargement on CAT was found in a significant proportion of both patient groups. Patients with such enlargement tended to have greater numbers of negative symptoms and poorer premorbid adjustment, but did not differ regarding family history of psychiatric illness. A subgroup of schizophrenics with presumed early brain damage was identified. This group had more marked ventricular enlargement, a greater number of negative symptoms, and an earlier onset of illness.
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U2 - 10.1097/00005053-198501000-00007
DO - 10.1097/00005053-198501000-00007
M3 - Article
C2 - 3965611
AN - SCOPUS:0021919245
SN - 0022-3018
VL - 173
SP - 42
EP - 50
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 1
ER -