Symposium report: Correlating in vitro data to in vivo findings for risk assessment

Ambuja S. Bale, Elaina Kenyon, Thomas J. Flynn, John C. Lipscomb, Donna L. Mendrick, Thomas Hartung, Geoffrey W. Patton

Research output: Contribution to journalArticle

Abstract

A special session at the Toxicology and Risk Assessment Conference in Cincinnati, OH, USA in May, 2012 presented approaches to expand current uses of in vitro toxicity data for risk assessment. Evaluation of xenobiotics through use of in vitro study methods is increasing exponentially and these methodologies offer a relatively fast and considerably cheaper way to determine toxicities in comparison to traditional animal-based approaches. One of the challenges with in vitro data is to effectively use this information for risk assessment purposes. Currently, in vitro studies are used as supportive information for hazard characterization and to identify mechanisms associated with toxicity. Being able to effectively correlate in vitro effects with in vivo observations represents a major challenge for risk assessors. The presentations in this special session provided innovative approaches toward effectively using in vitro data for the human health risk assessment process.

Original languageEnglish (US)
Pages (from-to)79-90
Number of pages12
JournalAltex
Volume31
Issue number1
DOIs
Publication statusPublished - 2014

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Keywords

  • Biomarkers
  • In vitro-to-in vivo correlation
  • Risk assessment
  • Toxome

ASJC Scopus subject areas

  • Medical Laboratory Technology
  • Pharmacology

Cite this

Bale, A. S., Kenyon, E., Flynn, T. J., Lipscomb, J. C., Mendrick, D. L., Hartung, T., & Patton, G. W. (2014). Symposium report: Correlating in vitro data to in vivo findings for risk assessment. Altex, 31(1), 79-90. https://doi.org/10.14573/altex.1310011