Sympathetic nervous activity to brown adipose tissue increases in cold-tolerant mice

Ryoichi Kawate, Mark I. Talan, Bernard T. Engel

Research output: Contribution to journalArticle

Abstract

Brown adipose tissue (BAT) is thought to be responsible for increased heat production in cold-acclimated rodents. We measured sympathetic nerve activity (SNA) in interscapular BAT (IBAT) during cold stimulation in cold-acclimated C57BL/6J mice (ACCLI). Cold acclimation was achieved (cold tolerance was increased) by repeated exposure to cold stress every other week for 3 weeks. We compared SNA in these animals with SNA in mice that had no previous cold stress experience (naive). During the test, mice were anesthetized by urethane and isoflurane and were paralyzed with vecuronium bromide. Sympathetic nerve activity was recorded directly from one of the fine nerves to IBAT. The animal's body caudal to the pelvic area was covered with a plastic bag containing a slurry of ice water to decrease colonic temperature 7°C below control level, which took approximately 20 min. Interscapular BAT-SNA increased during cold stress in both groups, but ACCLI mice had higher IBAT-SNA during cold stress than naive mice. These findings confirmed the hypothesis that during the acute cold exposure, cold-acclimated mice have greater sympathetic outflow to BAT adipocytes.

Original languageEnglish (US)
Pages (from-to)921-925
Number of pages5
JournalPhysiology and Behavior
Volume55
Issue number5
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Brown Adipose Tissue
Inbred C57BL Mouse
Vecuronium Bromide
Thermogenesis
Acclimatization
Isoflurane
Urethane
Ice
Adipocytes
Plastics
Rodentia

Keywords

  • Cold acclimation
  • Cold exposure
  • Cold stress
  • Mouse
  • Sympathetic nerve

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Sympathetic nervous activity to brown adipose tissue increases in cold-tolerant mice. / Kawate, Ryoichi; Talan, Mark I.; Engel, Bernard T.

In: Physiology and Behavior, Vol. 55, No. 5, 1994, p. 921-925.

Research output: Contribution to journalArticle

Kawate, Ryoichi ; Talan, Mark I. ; Engel, Bernard T. / Sympathetic nervous activity to brown adipose tissue increases in cold-tolerant mice. In: Physiology and Behavior. 1994 ; Vol. 55, No. 5. pp. 921-925.
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