Sympathectomy does not abolish bradykinin-induced cutaneous hyperalgesia in man

Research output: Contribution to journalArticle

Abstract

Bradykinin is an endogenous peptide that is thought to be a chemical mediator of the hyperalgesia following inflammation. In rat, bradykinin has been postulated to cause hyperalgesia to mechanical stimuli by releasing prostaglandin from sympathetic post-ganglionic terminals. The aim of this study was to determine whether bradykinin-induced cutaneous hyperalgesia in humans requires post-ganglionic sympathetic terminals. In humans, intradermal injection of bradykinin produces dramatic hyperalgesia to heat but not mechanical stimuli. Therefore, we measured the magnitude and duration of pain and hyperalgesia to heat stimuli following intradermal injection of bradykinin into the leg of a woman before and 6 months after an ipsilateral, surgical, lumbar sympathectomy. The pain and hyperalgesia to heat following bradykinin was found to be unaffected by the sympathectomy. These results suggest that the algesic effects of cutaneous bradykinin in human are independent of the sympathetic nervous system.

Original languageEnglish (US)
Pages (from-to)323-327
Number of pages5
JournalPain
Volume51
Issue number3
DOIs
StatePublished - Dec 1992

Keywords

  • Bradykinin
  • Hyperalgesia
  • Inflammation
  • Injury
  • Pain
  • Psychophysics
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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