Symmetry breaking in the life cycle of the budding yeast.

Brian D. Slaughter, Sarah E. Smith, Rong Li

Research output: Contribution to journalReview articlepeer-review

119 Scopus citations


The budding yeast Saccharomyces cerevisiae has been an invaluable model system for the study of the establishment of cellular asymmetry and growth polarity in response to specific physiological cues. A large body of experimental observations has shown that yeast cells are able to break symmetry and establish polarity through two coupled and partially redundant intrinsic mechanisms, even in the absence of any pre-existing external asymmetry. One of these mechanisms is dependent upon interplay between the actin cytoskeleton and the Rho family GTPase Cdc42, whereas the other relies on a Cdc42 GTPase signaling network. Integral to these mechanisms appear to be positive feedback loops capable of amplifying small and stochastic asymmetries. Spatial cues, such as bud scars and pheromone gradients, orient cell polarity by modulating the regulation of the Cdc42 GTPase cycle, thereby biasing the site of asymmetry amplification.

Original languageEnglish (US)
Pages (from-to)a003384
JournalCold Spring Harbor Perspectives in Biology
Issue number3
StatePublished - Sep 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Symmetry breaking in the life cycle of the budding yeast.'. Together they form a unique fingerprint.

Cite this