Sylvian fissure size in schizophrenia measured with the magnetic resonance imaging rating protocol of the consortium to establish a registry for Alzheimer's disease

Joseph Schwartz, Elizabeth H. Aylward, Patrick Ernest Barta, Larry E. Tune, Godfrey D. Pearlson

Research output: Contribution to journalArticle

Abstract

Objective: Since previous work indicated smaller than normal temporal lobe structures in schizophrenic patients, the authors tested the hypothesis that this abnormality might be reflected in abnormally large sylvian fissures. Method: The subjects were 48 schizophrenic patients and 51 normal comparison subjects matched groupwise with regard to age and sex. CSF spaces (sylvian fissures, temporal lobe sulci, temporal horns, third ventricle, lateral ventricles, and superficial cerebral sulci) were visually assessed with the magnetic resonance imaging rating protocol of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Results: The sylvian fissures of the schizophrenic patients were found to be bilaterally wider than those of the comparison subjects. There were no other significant differences. Conclusions: Schizophrenic patients appear to have larger than normal sylvian fissures, which may reflect smaller superior temporal gyri.

Original languageEnglish (US)
Pages (from-to)1195-1198
Number of pages4
JournalAmerican Journal of Psychiatry
Volume149
Issue number9
StatePublished - 1992

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Temporal Lobe
Registries
Schizophrenia
Alzheimer Disease
Magnetic Resonance Imaging
Third Ventricle
Lateral Ventricles

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

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title = "Sylvian fissure size in schizophrenia measured with the magnetic resonance imaging rating protocol of the consortium to establish a registry for Alzheimer's disease",
abstract = "Objective: Since previous work indicated smaller than normal temporal lobe structures in schizophrenic patients, the authors tested the hypothesis that this abnormality might be reflected in abnormally large sylvian fissures. Method: The subjects were 48 schizophrenic patients and 51 normal comparison subjects matched groupwise with regard to age and sex. CSF spaces (sylvian fissures, temporal lobe sulci, temporal horns, third ventricle, lateral ventricles, and superficial cerebral sulci) were visually assessed with the magnetic resonance imaging rating protocol of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Results: The sylvian fissures of the schizophrenic patients were found to be bilaterally wider than those of the comparison subjects. There were no other significant differences. Conclusions: Schizophrenic patients appear to have larger than normal sylvian fissures, which may reflect smaller superior temporal gyri.",
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T1 - Sylvian fissure size in schizophrenia measured with the magnetic resonance imaging rating protocol of the consortium to establish a registry for Alzheimer's disease

AU - Schwartz, Joseph

AU - Aylward, Elizabeth H.

AU - Barta, Patrick Ernest

AU - Tune, Larry E.

AU - Pearlson, Godfrey D.

PY - 1992

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AB - Objective: Since previous work indicated smaller than normal temporal lobe structures in schizophrenic patients, the authors tested the hypothesis that this abnormality might be reflected in abnormally large sylvian fissures. Method: The subjects were 48 schizophrenic patients and 51 normal comparison subjects matched groupwise with regard to age and sex. CSF spaces (sylvian fissures, temporal lobe sulci, temporal horns, third ventricle, lateral ventricles, and superficial cerebral sulci) were visually assessed with the magnetic resonance imaging rating protocol of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Results: The sylvian fissures of the schizophrenic patients were found to be bilaterally wider than those of the comparison subjects. There were no other significant differences. Conclusions: Schizophrenic patients appear to have larger than normal sylvian fissures, which may reflect smaller superior temporal gyri.

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