Sydenham's chorea: A possible presynaptic dopaminergic dysfunction initially

Sakkubai Naidu, N. Narasimhachari

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


A 10‐year‐old white girl showed chorea with elevated antibody titers indicative of an earlier group A streptococcal infection. Prior to treatment, cerebrospinal fluid homovanillic acid levels were markedly elevated. Haloperidol caused minimal improvement. She was then treated with reserpine alone, which resulted in remarkable improvement within one week. A repeat lumbar puncture one month after reserpine was started showed moderate reduction of homovanillic acid levels. When reserpine was discontinued, symptoms recurred. The data suggest presynaptic dopaminergic overactivity.

Original languageEnglish (US)
Pages (from-to)445-447
Number of pages3
JournalAnnals of neurology
Issue number4
StatePublished - Oct 1980
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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