Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology

Xiudong Liu, Weiming Xue, Qun Liu, Weiting Yu, Yingli Fu, Xin Xiong, Xiaojun Ma, Quan Yuan

Research output: Contribution to journalArticlepeer-review

Abstract

Swelling behaviour is one of the important properties for microcapsules made by hydrogels, which always affects the diffusion and release of drugs when the microcapsules are applied in drug delivery systems. In this paper, alginate-chitosan microcapsules were prepared by different technologies called external or internal gelation process respectively. With the volume swelling degree (Sw) as an index, the effect of properties of chitosan on the swelling behaviour of both microcapsules was investigated. It was demonstrated that the microcapsules with low molecular weight and high concentration of chitosan gave rise to low Sw. Considering the need of maintaining drug activity and drug loading, neutral pH and short gelation time were favorable. It was also noticed that Sw of internal gelation microcapsules was lower than that of external gelation microcapsules, which was interpreted by the structure analysis of internal or external gelation Ca-alginate beads with the aid of confocal laser scanning microscope.

Original languageEnglish (US)
Pages (from-to)459-464
Number of pages6
JournalCarbohydrate Polymers
Volume56
Issue number4
DOIs
StatePublished - Jul 15 2004
Externally publishedYes

Keywords

  • Alginate-chitosan microcapsule
  • External gelation
  • Internal gelation
  • Swelling behaviour

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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