Sweat and vitamin D status in congenital, lifetime, untreated GH deficiency

Cynthia S. Barros-Oliveira, Roberto Salvatori, Jéssica S.S. dos Santos, Paula F.C. Santos, Alécia A. Oliveira-Santos, Cindi G. Marinho, Elenilde G. Santos, Ângela C.G.B. Leal, Viviane C. Campos, Nayra P. Damascena, Carla R.P. Oliveira, Manuel H. Aguiar-Oliveira

Research output: Contribution to journalArticle

Abstract

Purpose: A reciprocal relationship exists between the skin and the GH/IGF-I axis. Skin produces both IGF- I and vitamin D, and GH and IGF-I exert several actions in the skin. Reduced sweating and altered phosphor-calcium homeostasis are occasionally reported in subjects with GH deficiency (GHD), mostly in the setting of hypopituitarism, therefore associated to other hormonal deficiencies. It is unclear whether these findings are due to GHD. The aim of this study was to assess skin function in subjects with isolated GHD (IGHD) due to a mutation in the GHRH receptor gene. Methods: In a cross-sectional study we enrolled 20 IGHD and 20 local controls. Sweating (volume, conductivity and chloride content) was assessed by a 30 min pilocarpine iontophoresis test, using the Macroduct® Sweat Collection System. IGF-I, Insulin, PTH, 25-hydroxyvitamin D, C-reactive protein (CRP), CPK, glucose, calcium, phosphate, alkaline phosphatase, total proteins and fractions, urinary calcium, and insulin were measured. HOMA-IR was calculated. Results: IGHD presented lower sweating, but normal vitamin D and phosphor-calcium homeostasis. Additionally, IGHD subjects presented lower HOMA-IR, higher CRP and reduced CPK. Conclusion: Untreated IGHD cause reduction in sweating, but does not affect phosphor-calcium homeostasis.

Original languageEnglish (US)
JournalEndocrine
DOIs
StatePublished - Jan 1 2019

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Sweating
Sweat
Insulin-Like Growth Factor I
Vitamin D
Calcium
Skin
Homeostasis
Pituitary Dwarfism
Insulin
Dilatation and Curettage
Iontophoresis
Hypopituitarism
Pilocarpine
C-Reactive Protein
Alkaline Phosphatase
Chlorides
Proteins
Cross-Sectional Studies
Glucose
Mutation

Keywords

  • GH deficiency
  • skin
  • sweat
  • vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Barros-Oliveira, C. S., Salvatori, R., dos Santos, J. S. S., Santos, P. F. C., Oliveira-Santos, A. A., Marinho, C. G., ... Aguiar-Oliveira, M. H. (2019). Sweat and vitamin D status in congenital, lifetime, untreated GH deficiency. Endocrine. https://doi.org/10.1007/s12020-019-01998-7

Sweat and vitamin D status in congenital, lifetime, untreated GH deficiency. / Barros-Oliveira, Cynthia S.; Salvatori, Roberto; dos Santos, Jéssica S.S.; Santos, Paula F.C.; Oliveira-Santos, Alécia A.; Marinho, Cindi G.; Santos, Elenilde G.; Leal, Ângela C.G.B.; Campos, Viviane C.; Damascena, Nayra P.; Oliveira, Carla R.P.; Aguiar-Oliveira, Manuel H.

In: Endocrine, 01.01.2019.

Research output: Contribution to journalArticle

Barros-Oliveira, CS, Salvatori, R, dos Santos, JSS, Santos, PFC, Oliveira-Santos, AA, Marinho, CG, Santos, EG, Leal, ÂCGB, Campos, VC, Damascena, NP, Oliveira, CRP & Aguiar-Oliveira, MH 2019, 'Sweat and vitamin D status in congenital, lifetime, untreated GH deficiency', Endocrine. https://doi.org/10.1007/s12020-019-01998-7
Barros-Oliveira CS, Salvatori R, dos Santos JSS, Santos PFC, Oliveira-Santos AA, Marinho CG et al. Sweat and vitamin D status in congenital, lifetime, untreated GH deficiency. Endocrine. 2019 Jan 1. https://doi.org/10.1007/s12020-019-01998-7
Barros-Oliveira, Cynthia S. ; Salvatori, Roberto ; dos Santos, Jéssica S.S. ; Santos, Paula F.C. ; Oliveira-Santos, Alécia A. ; Marinho, Cindi G. ; Santos, Elenilde G. ; Leal, Ângela C.G.B. ; Campos, Viviane C. ; Damascena, Nayra P. ; Oliveira, Carla R.P. ; Aguiar-Oliveira, Manuel H. / Sweat and vitamin D status in congenital, lifetime, untreated GH deficiency. In: Endocrine. 2019.
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abstract = "Purpose: A reciprocal relationship exists between the skin and the GH/IGF-I axis. Skin produces both IGF- I and vitamin D, and GH and IGF-I exert several actions in the skin. Reduced sweating and altered phosphor-calcium homeostasis are occasionally reported in subjects with GH deficiency (GHD), mostly in the setting of hypopituitarism, therefore associated to other hormonal deficiencies. It is unclear whether these findings are due to GHD. The aim of this study was to assess skin function in subjects with isolated GHD (IGHD) due to a mutation in the GHRH receptor gene. Methods: In a cross-sectional study we enrolled 20 IGHD and 20 local controls. Sweating (volume, conductivity and chloride content) was assessed by a 30 min pilocarpine iontophoresis test, using the Macroduct{\circledR} Sweat Collection System. IGF-I, Insulin, PTH, 25-hydroxyvitamin D, C-reactive protein (CRP), CPK, glucose, calcium, phosphate, alkaline phosphatase, total proteins and fractions, urinary calcium, and insulin were measured. HOMA-IR was calculated. Results: IGHD presented lower sweating, but normal vitamin D and phosphor-calcium homeostasis. Additionally, IGHD subjects presented lower HOMA-IR, higher CRP and reduced CPK. Conclusion: Untreated IGHD cause reduction in sweating, but does not affect phosphor-calcium homeostasis.",
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AU - Santos, Paula F.C.

AU - Oliveira-Santos, Alécia A.

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AB - Purpose: A reciprocal relationship exists between the skin and the GH/IGF-I axis. Skin produces both IGF- I and vitamin D, and GH and IGF-I exert several actions in the skin. Reduced sweating and altered phosphor-calcium homeostasis are occasionally reported in subjects with GH deficiency (GHD), mostly in the setting of hypopituitarism, therefore associated to other hormonal deficiencies. It is unclear whether these findings are due to GHD. The aim of this study was to assess skin function in subjects with isolated GHD (IGHD) due to a mutation in the GHRH receptor gene. Methods: In a cross-sectional study we enrolled 20 IGHD and 20 local controls. Sweating (volume, conductivity and chloride content) was assessed by a 30 min pilocarpine iontophoresis test, using the Macroduct® Sweat Collection System. IGF-I, Insulin, PTH, 25-hydroxyvitamin D, C-reactive protein (CRP), CPK, glucose, calcium, phosphate, alkaline phosphatase, total proteins and fractions, urinary calcium, and insulin were measured. HOMA-IR was calculated. Results: IGHD presented lower sweating, but normal vitamin D and phosphor-calcium homeostasis. Additionally, IGHD subjects presented lower HOMA-IR, higher CRP and reduced CPK. Conclusion: Untreated IGHD cause reduction in sweating, but does not affect phosphor-calcium homeostasis.

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