Swallowing intentional off-state in aging and alzheimer's disease: Preliminary study

Ianessa A. Humbert, Donald G. McLaren, Georgia Malandraki, Sterling C. Johnson, Joanne Robbins

Research output: Contribution to journalArticlepeer-review

Abstract

Frontal cortical activation is elicited when subjects have been instructed not to initiate a sensorimotor task. The goal of this preliminary fMRI study was to examine BOLD response to a "Do Not Swallow" instruction (an intentional "off-state") in the context of other swallowing tasks in 3 groups of participants (healthy young, healthy old, and early Alzheimer's disease (AD)). Overall, the older group had larger, bilaterally active clusters in the cortex, including the dorsomedial prefrontal cortex during the intentional swallowing off-state; this region is commonly active in response inhibition studies. Disease-related differences were evident where the AD group had significantly greater BOLD response in the insula/operculum than the old. These findings have significant clinical implications for control of swallowing across the age span and in neurodegenerative disease. Greater activation in the insula/operculum for the AD group supports previous studies where this region is associated with initiating swallowing. The AD group may have required more effort to "turn off" swallowing centers to reach the intentional swallowing off-state.

Original languageEnglish (US)
Pages (from-to)347-354
Number of pages8
JournalJournal of Alzheimer's Disease
Volume26
Issue number2
DOIs
StatePublished - 2011

Keywords

  • Alzheimer's disease
  • cognitive aging
  • deglutition
  • fMRI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Swallowing intentional off-state in aging and alzheimer's disease: Preliminary study'. Together they form a unique fingerprint.

Cite this