SV40 Neutralizing antibodies in sera of US residents without history of polio immunization

Keerti V. Shah, Harvey L. Ozer, Harry S. Pond, Loreto D. Palma, Gerald P. Murphy

Research output: Contribution to journalArticle

Abstract

SIMIAN virus 40 (SV40) is a natural infection of rhesus and some other Asiatic macaques1 and has no known natural host in the United States. It is therefore difficult to account for our finding of antibodies neutralizing SV40 in the sera of some elderly persons in the United States who do not have a history of immunization with any vaccine prepared in rhesus kidney cultures. The only recognized exposure of the US population to this virus occurred when poliovirus and adenovirus vaccines prepared in rhesus kidney cultures and administered to a large number of people were later found to have been contaminated with SV40 (ref. 1). The chief exposure occurred between 1955 and 1961 through the use of Salk vaccine, and it is known that subcutaneous administration of SV40 gives a long-lasting antibody response2.

Original languageEnglish (US)
Pages (from-to)448-449
Number of pages2
JournalNature
Volume231
Issue number5303
DOIs
StatePublished - Dec 1 1971

ASJC Scopus subject areas

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    Shah, K. V., Ozer, H. L., Pond, H. S., Palma, L. D., & Murphy, G. P. (1971). SV40 Neutralizing antibodies in sera of US residents without history of polio immunization. Nature, 231(5303), 448-449. https://doi.org/10.1038/231448a0