Sustained Sexual Behavior Change after Acute HIV Diagnosis in Malawi

Katherine B. Rucinski; Sarah E. Rutstein; Kimberly A. Powers; Dana K. Pasquale; Ann M. Dennis; Sam Phiri; Mina C. Hosseinipour; Gift Kamanga; Dominic Nsona; Cecilia Massa; Irving F. Hoffman; William C. Miller; Audrey E. Pettifor

doi:10.1097/OLQ.0000000000000873

Sustained Sexual Behavior Change after Acute HIV Diagnosis in Malawi

Katherine B. Rucinski, Sarah E. Rutstein, Kimberly A. Powers, Dana K. Pasquale, Ann M. Dennis, Sam Phiri, Mina C. Hosseinipour, Gift Kamanga, Dominic Nsona, Cecilia Massa, Irving F. Hoffman, William C. Miller, Audrey E. Pettifor

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background Identification of acute HIV infection (AHI) allows for important opportunities for HIV prevention through behavior change and biomedical intervention. Here, we evaluate changes in sexual risk behaviors among persons with AHI enrolled in a combined behavioral and biomedical intervention designed to reduce onward transmission of HIV. Methods Participants were randomized to standard HIV counseling, a multisession behavioral intervention, or a multisession behavioral intervention plus antiretrovirals. Sexual behaviors were assessed periodically over 1 year. Results Four weeks after diagnosis, the predicted probability of reporting multiple sexual partners decreased from 24% to 9%, and the probability of reporting unprotected sex decreased from 71% to 27%. These declines in sexual risk behaviors were sustained over follow-up irrespective of study arm. Conclusions Diagnosis of AHI alone may be sufficient to achieve immediate and sustained behavior change during this highly infectious period.

Original language	English (US)
Pages (from-to)	741-746
Number of pages	6
Journal	Sexually transmitted diseases
Volume	45
Issue number	11
DOIs	https://doi.org/10.1097/OLQ.0000000000000873
State	Published - Nov 1 2018
Externally published	Yes

ASJC Scopus subject areas

Dermatology
Public Health, Environmental and Occupational Health
Microbiology (medical)
Infectious Diseases

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10.1097/OLQ.0000000000000873

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@article{b649777693e847f1afc460bf3dced28f,

title = "Sustained Sexual Behavior Change after Acute HIV Diagnosis in Malawi",

abstract = "Background Identification of acute HIV infection (AHI) allows for important opportunities for HIV prevention through behavior change and biomedical intervention. Here, we evaluate changes in sexual risk behaviors among persons with AHI enrolled in a combined behavioral and biomedical intervention designed to reduce onward transmission of HIV. Methods Participants were randomized to standard HIV counseling, a multisession behavioral intervention, or a multisession behavioral intervention plus antiretrovirals. Sexual behaviors were assessed periodically over 1 year. Results Four weeks after diagnosis, the predicted probability of reporting multiple sexual partners decreased from 24% to 9%, and the probability of reporting unprotected sex decreased from 71% to 27%. These declines in sexual risk behaviors were sustained over follow-up irrespective of study arm. Conclusions Diagnosis of AHI alone may be sufficient to achieve immediate and sustained behavior change during this highly infectious period.",

author = "Rucinski, {Katherine B.} and Rutstein, {Sarah E.} and Powers, {Kimberly A.} and Pasquale, {Dana K.} and Dennis, {Ann M.} and Sam Phiri and Hosseinipour, {Mina C.} and Gift Kamanga and Dominic Nsona and Cecilia Massa and Hoffman, {Irving F.} and Miller, {William C.} and Pettifor, {Audrey E.}",

note = "Funding Information: Conflicts of Interest and Sources of Funding: This work was funded by the National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (R01 AI083059) and supported by the UNC Center for AIDS Research, an NIH-funded program (P30 AI50410). S.E.R. was supported by the NIH/National Institute of Mental Health (F30 MH098731) and NIH/National Institute of General Medical Sciences (T32 GM008719). D.K.P. was supported by the NIH/ National Institute of Allergy and Infectious Diseases (T32 AI070114). No conflicts of interest were declared. Publisher Copyright: Copyright {\textcopyright} 2018 American Sexually Transmitted Diseases Association All rights reserved.",

year = "2018",

month = nov,

day = "1",

doi = "10.1097/OLQ.0000000000000873",

language = "English (US)",

volume = "45",

pages = "741--746",

journal = "Sexually transmitted diseases",

issn = "0148-5717",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Sustained Sexual Behavior Change after Acute HIV Diagnosis in Malawi

AU - Rucinski, Katherine B.

AU - Rutstein, Sarah E.

AU - Powers, Kimberly A.

AU - Pasquale, Dana K.

AU - Dennis, Ann M.

AU - Phiri, Sam

AU - Hosseinipour, Mina C.

AU - Kamanga, Gift

AU - Nsona, Dominic

AU - Massa, Cecilia

AU - Hoffman, Irving F.

AU - Miller, William C.

AU - Pettifor, Audrey E.

N1 - Funding Information: Conflicts of Interest and Sources of Funding: This work was funded by the National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (R01 AI083059) and supported by the UNC Center for AIDS Research, an NIH-funded program (P30 AI50410). S.E.R. was supported by the NIH/National Institute of Mental Health (F30 MH098731) and NIH/National Institute of General Medical Sciences (T32 GM008719). D.K.P. was supported by the NIH/ National Institute of Allergy and Infectious Diseases (T32 AI070114). No conflicts of interest were declared. Publisher Copyright: Copyright © 2018 American Sexually Transmitted Diseases Association All rights reserved.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background Identification of acute HIV infection (AHI) allows for important opportunities for HIV prevention through behavior change and biomedical intervention. Here, we evaluate changes in sexual risk behaviors among persons with AHI enrolled in a combined behavioral and biomedical intervention designed to reduce onward transmission of HIV. Methods Participants were randomized to standard HIV counseling, a multisession behavioral intervention, or a multisession behavioral intervention plus antiretrovirals. Sexual behaviors were assessed periodically over 1 year. Results Four weeks after diagnosis, the predicted probability of reporting multiple sexual partners decreased from 24% to 9%, and the probability of reporting unprotected sex decreased from 71% to 27%. These declines in sexual risk behaviors were sustained over follow-up irrespective of study arm. Conclusions Diagnosis of AHI alone may be sufficient to achieve immediate and sustained behavior change during this highly infectious period.

AB - Background Identification of acute HIV infection (AHI) allows for important opportunities for HIV prevention through behavior change and biomedical intervention. Here, we evaluate changes in sexual risk behaviors among persons with AHI enrolled in a combined behavioral and biomedical intervention designed to reduce onward transmission of HIV. Methods Participants were randomized to standard HIV counseling, a multisession behavioral intervention, or a multisession behavioral intervention plus antiretrovirals. Sexual behaviors were assessed periodically over 1 year. Results Four weeks after diagnosis, the predicted probability of reporting multiple sexual partners decreased from 24% to 9%, and the probability of reporting unprotected sex decreased from 71% to 27%. These declines in sexual risk behaviors were sustained over follow-up irrespective of study arm. Conclusions Diagnosis of AHI alone may be sufficient to achieve immediate and sustained behavior change during this highly infectious period.

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Sustained Sexual Behavior Change after Acute HIV Diagnosis in Malawi

Abstract

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