Sustained release of galardin and taxol from gelatin chondroitin sulfate coacervate films

Phillip F. Heller, G. Mark Jenkins, Linda Cheng, Kam Leong, Wen Shao, Jeffrey Brinker, Earl Hope, Cynthia Nater, Edward Lakatta, Jeffrey P. Froelich

Research output: Contribution to journalConference article

Abstract

There has been no effective strategy for preventing restenosis in man. Therapeutic strategies have focused on limiting intimal hyperplasia and its physiologic consequences. Although many drugs have been tested with some success in animal models, none have been effective in preventing restenosis in clinical trials. In this study, two hydrophobic drugs, Galardin and Taxol, are evaluated for their effect on neointimal hyperoplasia after loading into gelatin-chondroitin sulfate films. Galardin is an experimental peptide analogue, which has recently been shown to inhibit matrix metalloproteinases; Taxol is an antineoplastic drug, which has been shown to inhibit neointimal proliferation in the rat when delivered systematically. Two animal models, rat and minipig, have been used to test the effects of Galardin and Taxol for restenosis.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalMaterials Research Society Symposium - Proceedings
Volume394
DOIs
StatePublished - 1995
EventProceedings of the 1995 MRS Spring Meeting - San Francisco, CA, USA
Duration: Apr 17 1995Apr 21 1995

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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