Sustained proliferation in cancer

Mechanisms and novel therapeutic targets

Mark A. Feitelson, Alla Arzumanyan, Rob J. Kulathinal, Stacy W. Blain, Randall F. Holcombe, Jamal Mahajna, Maria Marino, Maria L. Martinez-Chantar, Roman Nawroth, Isidro Sanchez-Garcia, Dipali Sharma, Neeraj K. Saxena, Neetu Singh, Panagiotis J. Vlachostergios, Shanchun Guo, Kanya Honoki, Hiromasa Fujii, Alexandros G. Georgakilas, Amedeo Amedei, Elena Niccolai & 12 others Amr Amin, S. Salman Ashraf, Chandra S. Boosani, Gunjan Guha, Maria Rosa Ciriolo, Katia Aquilano, Sophie Chen, Sulma I. Mohammed, Asfar S. Azmi, Dipita Bhakta, Dorota Halicka, Somaira Nowsheen

Research output: Contribution to journalArticle

Abstract

Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifested by alterations in cell metabolism. Once tumors appear, growth and metastasis may be supported by overproduction of appropriate hormones (in hormonally dependent cancers), by promoting angiogenesis, by undergoing epithelial to mesenchymal transition, by triggering autophagy, and by taking cues from surrounding stromal cells. A number of natural compounds (e.g., curcumin, resveratrol, indole-3-carbinol, brassinin, sulforaphane, epigallocatechin-3-gallate, genistein, ellagitannins, lycopene and quercetin) have been found to inhibit one or more pathways that contribute to proliferation (e.g., hypoxia inducible factor 1, nuclear factor kappa B, phosphoinositide 3 kinase/Akt, insulin-like growth factor receptor 1, Wnt, cell cycle associated proteins, as well as androgen and estrogen receptor signaling). These data, in combination with bioinformatics analyses, will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression.

Original languageEnglish (US)
JournalSeminars in Cancer Biology
DOIs
StateAccepted/In press - 2015
Externally publishedYes

Fingerprint

Cell Cycle Proteins
Neoplastic Stem Cells
Neoplasms
Hydrolyzable Tannins
Activity Cycles
Somatomedin Receptors
Therapeutics
Hypoxia-Inducible Factor 1
Curcumin
Epithelial-Mesenchymal Transition
1-Phosphatidylinositol 4-Kinase
NF-kappa B
Genistein
Quercetin
Autophagy
Androgen Receptors
Drug Combinations
Stromal Cells
Growth
Computational Biology

Keywords

  • Cancer hallmarks
  • Cancer stem cells
  • Natural products
  • Proliferation
  • Therapeutic targets

ASJC Scopus subject areas

  • Cancer Research

Cite this

Feitelson, M. A., Arzumanyan, A., Kulathinal, R. J., Blain, S. W., Holcombe, R. F., Mahajna, J., ... Nowsheen, S. (Accepted/In press). Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2015.02.006

Sustained proliferation in cancer : Mechanisms and novel therapeutic targets. / Feitelson, Mark A.; Arzumanyan, Alla; Kulathinal, Rob J.; Blain, Stacy W.; Holcombe, Randall F.; Mahajna, Jamal; Marino, Maria; Martinez-Chantar, Maria L.; Nawroth, Roman; Sanchez-Garcia, Isidro; Sharma, Dipali; Saxena, Neeraj K.; Singh, Neetu; Vlachostergios, Panagiotis J.; Guo, Shanchun; Honoki, Kanya; Fujii, Hiromasa; Georgakilas, Alexandros G.; Amedei, Amedeo; Niccolai, Elena; Amin, Amr; Ashraf, S. Salman; Boosani, Chandra S.; Guha, Gunjan; Ciriolo, Maria Rosa; Aquilano, Katia; Chen, Sophie; Mohammed, Sulma I.; Azmi, Asfar S.; Bhakta, Dipita; Halicka, Dorota; Nowsheen, Somaira.

In: Seminars in Cancer Biology, 2015.

Research output: Contribution to journalArticle

Feitelson, MA, Arzumanyan, A, Kulathinal, RJ, Blain, SW, Holcombe, RF, Mahajna, J, Marino, M, Martinez-Chantar, ML, Nawroth, R, Sanchez-Garcia, I, Sharma, D, Saxena, NK, Singh, N, Vlachostergios, PJ, Guo, S, Honoki, K, Fujii, H, Georgakilas, AG, Amedei, A, Niccolai, E, Amin, A, Ashraf, SS, Boosani, CS, Guha, G, Ciriolo, MR, Aquilano, K, Chen, S, Mohammed, SI, Azmi, AS, Bhakta, D, Halicka, D & Nowsheen, S 2015, 'Sustained proliferation in cancer: Mechanisms and novel therapeutic targets', Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2015.02.006
Feitelson, Mark A. ; Arzumanyan, Alla ; Kulathinal, Rob J. ; Blain, Stacy W. ; Holcombe, Randall F. ; Mahajna, Jamal ; Marino, Maria ; Martinez-Chantar, Maria L. ; Nawroth, Roman ; Sanchez-Garcia, Isidro ; Sharma, Dipali ; Saxena, Neeraj K. ; Singh, Neetu ; Vlachostergios, Panagiotis J. ; Guo, Shanchun ; Honoki, Kanya ; Fujii, Hiromasa ; Georgakilas, Alexandros G. ; Amedei, Amedeo ; Niccolai, Elena ; Amin, Amr ; Ashraf, S. Salman ; Boosani, Chandra S. ; Guha, Gunjan ; Ciriolo, Maria Rosa ; Aquilano, Katia ; Chen, Sophie ; Mohammed, Sulma I. ; Azmi, Asfar S. ; Bhakta, Dipita ; Halicka, Dorota ; Nowsheen, Somaira. / Sustained proliferation in cancer : Mechanisms and novel therapeutic targets. In: Seminars in Cancer Biology. 2015.
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AU - Feitelson, Mark A.

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AU - Kulathinal, Rob J.

AU - Blain, Stacy W.

AU - Holcombe, Randall F.

AU - Mahajna, Jamal

AU - Marino, Maria

AU - Martinez-Chantar, Maria L.

AU - Nawroth, Roman

AU - Sanchez-Garcia, Isidro

AU - Sharma, Dipali

AU - Saxena, Neeraj K.

AU - Singh, Neetu

AU - Vlachostergios, Panagiotis J.

AU - Guo, Shanchun

AU - Honoki, Kanya

AU - Fujii, Hiromasa

AU - Georgakilas, Alexandros G.

AU - Amedei, Amedeo

AU - Niccolai, Elena

AU - Amin, Amr

AU - Ashraf, S. Salman

AU - Boosani, Chandra S.

AU - Guha, Gunjan

AU - Ciriolo, Maria Rosa

AU - Aquilano, Katia

AU - Chen, Sophie

AU - Mohammed, Sulma I.

AU - Azmi, Asfar S.

AU - Bhakta, Dipita

AU - Halicka, Dorota

AU - Nowsheen, Somaira

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