Abstract
The susceptibility of cortical neurons to two forms of apoptotic death was compared with susceptibility to excitotoxic death during development in vitro (DIV 4-21). Murine cortical cultures were exposed for 48 h to the phosphatase inhibitor cyclosporine, the protein kinase inhibitor staurosporine or the excitotoxin N-methyl-D-aspartate (NMDA). Susceptibility to apoptosis induced by staurosporine or cyclosporine was maximal between DIV 4-10 and declined from DIV 10 through 18. The opposite pattern was observed with susceptibility to NMDA receptor-mediated excitotoxic necrosis, which was minimal at DIV 6 and progressively increased through DIV 21.
Original language | English (US) |
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Pages (from-to) | 228-232 |
Number of pages | 5 |
Journal | Brain research |
Volume | 759 |
Issue number | 2 |
DOIs | |
State | Published - Jun 6 1997 |
Keywords
- Aptoptosis
- Cyclosporine
- Development
- Excitotoxicity
- N- Methyl-D-aspartate (NMDA)
- Neuronal culture
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology