Susceptibility to apoptosis is enhanced in immature cortical neurons

John W. McDonald, Maria I. Behrens, Chris Chung, Tim Bhattacharyya, Dennis W. Choi

Research output: Contribution to journalArticlepeer-review

Abstract

The susceptibility of cortical neurons to two forms of apoptotic death was compared with susceptibility to excitotoxic death during development in vitro (DIV 4-21). Murine cortical cultures were exposed for 48 h to the phosphatase inhibitor cyclosporine, the protein kinase inhibitor staurosporine or the excitotoxin N-methyl-D-aspartate (NMDA). Susceptibility to apoptosis induced by staurosporine or cyclosporine was maximal between DIV 4-10 and declined from DIV 10 through 18. The opposite pattern was observed with susceptibility to NMDA receptor-mediated excitotoxic necrosis, which was minimal at DIV 6 and progressively increased through DIV 21.

Original languageEnglish (US)
Pages (from-to)228-232
Number of pages5
JournalBrain research
Volume759
Issue number2
DOIs
StatePublished - Jun 6 1997

Keywords

  • Aptoptosis
  • Cyclosporine
  • Development
  • Excitotoxicity
  • N- Methyl-D-aspartate (NMDA)
  • Neuronal culture

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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