TY - JOUR
T1 - Susceptibility testing of filamentous fungi to amphotericin B by a rapid radiometric method
AU - Merz, W. G.
AU - Fay, D.
AU - Thumar, B.
AU - Dixon, D.
PY - 1984
Y1 - 1984
N2 - A rapid, radiometric method was developed to determine the susceptibility of filamentous fungi to amphotericin B. The rapid radiometric method depended on measurement of the inhibition of 14CO2 production in the presence of amphotericin B. Thirty isolates of filamentous fungi were tested by the rapid, radiometric method and a reference agar dilution method. There was 93% agreement between the two methods when an 80% or greater decrease in CO2 production was used to calculate the minimal inhibitory concentration with the rapid, radiometric method. Minimal inhibitory concentrations, based on 80% decrease of CO2 production, were achieved within 24 h of incubation with all of the fungi tested.
AB - A rapid, radiometric method was developed to determine the susceptibility of filamentous fungi to amphotericin B. The rapid radiometric method depended on measurement of the inhibition of 14CO2 production in the presence of amphotericin B. Thirty isolates of filamentous fungi were tested by the rapid, radiometric method and a reference agar dilution method. There was 93% agreement between the two methods when an 80% or greater decrease in CO2 production was used to calculate the minimal inhibitory concentration with the rapid, radiometric method. Minimal inhibitory concentrations, based on 80% decrease of CO2 production, were achieved within 24 h of incubation with all of the fungi tested.
UR - http://www.scopus.com/inward/record.url?scp=0021367782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021367782&partnerID=8YFLogxK
U2 - 10.1128/jcm.19.1.54-56.1984
DO - 10.1128/jcm.19.1.54-56.1984
M3 - Article
C2 - 6418762
AN - SCOPUS:0021367782
SN - 0095-1137
VL - 19
SP - 54
EP - 56
JO - Journal of clinical microbiology
JF - Journal of clinical microbiology
IS - 1
ER -