Susceptibility of skeletal muscle to Coxsackie A2 virus infection: Effects of botulinum toxin and denervation

Clifford Andrew, Daniel B Drachman, Alan Pestronk, Opendra Narayan

Research output: Contribution to journalArticle

Abstract

Coxsackie A viruses can infect denervated but not innervated mature skeletal muscles. The role of synaptic transmission in preventing susceptibility to Coxsackievirus infection was studied by surgically denervating leg muscles of mice or injecting the muscles with botulinum toxin to block quantal release of acetylcholine. Control muscles were injected with heat-inactivated toxin. Subsequent injection of Coxsackie A2 virus resulted in extensive virus replication and tissue destruction in the denervated and botulinum toxin-treated muscles, while the control muscles showed only minimal changes. This suggests that the susceptibility of skeletal muscle to Coxsackievirus infection is regulated by synoptic transmission.

Original languageEnglish (US)
Pages (from-to)714-716
Number of pages3
JournalScience
Volume223
Issue number4637
StatePublished - 1984

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Coxsackievirus Infections
Botulinum Toxins
Denervation
varespladib methyl
Skeletal Muscle
Muscles
Enterovirus
Virus Replication
Synaptic Transmission
Acetylcholine
Leg
Hot Temperature
Injections

ASJC Scopus subject areas

  • General

Cite this

Susceptibility of skeletal muscle to Coxsackie A2 virus infection : Effects of botulinum toxin and denervation. / Andrew, Clifford; Drachman, Daniel B; Pestronk, Alan; Narayan, Opendra.

In: Science, Vol. 223, No. 4637, 1984, p. 714-716.

Research output: Contribution to journalArticle

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