Susceptibility of select agents to predation by predatory bacteria

Riccardo Russo, Richard Chae, Somdatta Mukherjee, Eric J. Singleton, James L. Occi, Daniel E. Kadouri, Nancy D. Connell

Research output: Contribution to journalArticlepeer-review


Select Agents are microorganisms and toxins considered to be exploitable as biological weapons. Although infections by many Select Agents can be treated by conventional antibiotics, the risk of an emerging or engineered drug resistant strain is of great concern. One group of microorganisms that is showing potential to control drug resistant Gram-negative bacteria are the predatory bacteria from the genera Bdellovibrio spp. and Micavibrio spp. In this study, we have examined the ability of Bdellovibrio bacteriovorus (B. bacteriovorus) strain 109J, HD100 and Micavibrio aeruginosavorus (M. aeruginosavorus) ARL-13 to prey on a variety of Select Agents. Our findings demonstrate that B. bacteriovorus and M. aeruginosavorus are able to prey efficiently on Yersinia pestis and Burkholderia mallei. Modest predation was also measured in co-cultures of B. bacteriovorus and Francisella tularensis. However, neither of the predators showed predation when Burkholderia pseudomallei and Brucella melitensis were used as prey.

Original languageEnglish (US)
Pages (from-to)903-912
Number of pages10
Issue number4
StatePublished - Dec 2015
Externally publishedYes


  • Bdellovibrio
  • Micavibrio
  • Predatory bacteria
  • Select Agents

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology


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