Abstract
To evaluate the relative activity of fourteen beta-lactam agents, including seven new agents, the susceptibility of 77 clinical isolates of group B streptococci were measured using an agar dilution technique. Thienamycin, cefotaxime and azlocillin had better activity than penicillin, with MIC50 of ≤ 0.015 μg/ml. Ampicillin, cefamandole, cefazolin, cefoperazone, mezlocillin and piperacillin had activity similar to penicillin with MIC50 of 0.03-0.06 μg/ml. Oxacillin, ticarcillin, cefoxitin and moxalactam were less active than penicillin with MIC50 of 0.25-2 μg/ml. Susceptibility to five of the more active antibiotics was markedly reduced, however, when the inoculum size was increased from 104 to 108 colony forming units/ml.
Original language | English (US) |
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Pages (from-to) | 693-696 |
Number of pages | 4 |
Journal | Drugs under Experimental and Clinical Research |
Volume | 9 |
Issue number | 10 |
State | Published - Jan 1 1983 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Pharmacology (medical)