Abstract
To evaluate the relative activity of fourteen beta-lactam agents, including seven new agents, the susceptibility of 77 clinical isolates of group B streptococci were measured using an agar dilution technique. Thienamycin, cefotaxime and azlocillin had better activity than penicillin, with MIC50 of ≤ 0.015 μg/ml. Ampicillin, cefamandole, cefazolin, cefoperazone, mezlocillin and piperacillin had activity similar to penicillin with MIC50 of 0.03-0.06 μg/ml. Oxacillin, ticarcillin, cefoxitin and moxalactam were less active than penicillin with MIC50 of 0.25-2 μg/ml. Susceptibility to five of the more active antibiotics was markedly reduced, however, when the inoculum size was increased from 104 to 108 colony forming units/ml.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 693-696 |
| Number of pages | 4 |
| Journal | Drugs under Experimental and Clinical Research |
| Volume | 9 |
| Issue number | 10 |
| State | Published - 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology (medical)
- Drug Discovery
- Pharmacology
Cite this
Susceptibility of group B streptococcus to beta-lactam antibiotics. / McGeary, S. A.; Kim, Kwang Sik; Ward, J. I.
In: Drugs under Experimental and Clinical Research, Vol. 9, No. 10, 1983, p. 693-696.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Susceptibility of group B streptococcus to beta-lactam antibiotics
AU - McGeary, S. A.
AU - Kim, Kwang Sik
AU - Ward, J. I.
PY - 1983
Y1 - 1983
N2 - To evaluate the relative activity of fourteen beta-lactam agents, including seven new agents, the susceptibility of 77 clinical isolates of group B streptococci were measured using an agar dilution technique. Thienamycin, cefotaxime and azlocillin had better activity than penicillin, with MIC50 of ≤ 0.015 μg/ml. Ampicillin, cefamandole, cefazolin, cefoperazone, mezlocillin and piperacillin had activity similar to penicillin with MIC50 of 0.03-0.06 μg/ml. Oxacillin, ticarcillin, cefoxitin and moxalactam were less active than penicillin with MIC50 of 0.25-2 μg/ml. Susceptibility to five of the more active antibiotics was markedly reduced, however, when the inoculum size was increased from 104 to 108 colony forming units/ml.
AB - To evaluate the relative activity of fourteen beta-lactam agents, including seven new agents, the susceptibility of 77 clinical isolates of group B streptococci were measured using an agar dilution technique. Thienamycin, cefotaxime and azlocillin had better activity than penicillin, with MIC50 of ≤ 0.015 μg/ml. Ampicillin, cefamandole, cefazolin, cefoperazone, mezlocillin and piperacillin had activity similar to penicillin with MIC50 of 0.03-0.06 μg/ml. Oxacillin, ticarcillin, cefoxitin and moxalactam were less active than penicillin with MIC50 of 0.25-2 μg/ml. Susceptibility to five of the more active antibiotics was markedly reduced, however, when the inoculum size was increased from 104 to 108 colony forming units/ml.
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M3 - Article
AN - SCOPUS:0021022309
VL - 9
SP - 693
EP - 696
JO - Drugs under Experimental and Clinical Research
JF - Drugs under Experimental and Clinical Research
SN - 0378-6501
IS - 10
ER -