Susceptibility of group B streptococcus to beta-lactam antibiotics

S. A. McGeary, Kwang Sik Kim, J. I. Ward

Research output: Contribution to journalArticle

Abstract

To evaluate the relative activity of fourteen beta-lactam agents, including seven new agents, the susceptibility of 77 clinical isolates of group B streptococci were measured using an agar dilution technique. Thienamycin, cefotaxime and azlocillin had better activity than penicillin, with MIC50 of ≤ 0.015 μg/ml. Ampicillin, cefamandole, cefazolin, cefoperazone, mezlocillin and piperacillin had activity similar to penicillin with MIC50 of 0.03-0.06 μg/ml. Oxacillin, ticarcillin, cefoxitin and moxalactam were less active than penicillin with MIC50 of 0.25-2 μg/ml. Susceptibility to five of the more active antibiotics was markedly reduced, however, when the inoculum size was increased from 104 to 108 colony forming units/ml.

Original languageEnglish (US)
Pages (from-to)693-696
Number of pages4
JournalDrugs under Experimental and Clinical Research
Volume9
Issue number10
StatePublished - 1983
Externally publishedYes

Fingerprint

Streptococcus agalactiae
beta-Lactams
Penicillins
Anti-Bacterial Agents
Azlocillin
Mezlocillin
Cefamandole
Moxalactam
Ticarcillin
Cefoperazone
Indicator Dilution Techniques
Cefoxitin
Cefazolin
Oxacillin
Piperacillin
Cefotaxime
Ampicillin
Agar
Stem Cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology

Cite this

Susceptibility of group B streptococcus to beta-lactam antibiotics. / McGeary, S. A.; Kim, Kwang Sik; Ward, J. I.

In: Drugs under Experimental and Clinical Research, Vol. 9, No. 10, 1983, p. 693-696.

Research output: Contribution to journalArticle

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