Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children

D. K. Amre, D. R. MacK, K. Morgan, D. Israel, C. Deslandres, E. G. Seidman, P. Lambrette, I. Costea, A. Krupoves, H. Fegury, J. Dong, G. Grimard, E. Levy

Research output: Contribution to journalArticle

Abstract

Background Recent genome-wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn's disease (CD). Aims To investigate whether reported genes/loci were also associated with CD in Canadian children. Design and Methods A case-control design was implemented at three paediatric gastroenterology clinics in Canada. Children ≤18 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in five genome-wide association studies reported genes/loci were genotyped. Associations between individual SNPs and CD were examined. Results A total of 406 cases and 415 controls were studied. The mean (±s.d.) age of the cases was 12.3 (±3.2) years. Most cases were male (56.6%), had ileo-colonic disease (L3 ± L4, 52.0%) and inflammatory behaviour (B1 ± p, 86.9%) at diagnosis. Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01). Associations with SNP rs4613763 in the PTGER4 locus were marginally nonsignificant (P = 0.07). The ZNF365 and STAT3 SNPs were predominantly associated with ileal disease with or without colonic involvement. Conclusion The identified susceptibility genes/loci for adult-onset CD also confer risk for paediatric-onset CD.

Original languageEnglish (US)
Pages (from-to)1186-1191
Number of pages6
JournalAlimentary Pharmacology and Therapeutics
Volume31
Issue number11
DOIs
StatePublished - Jun 2010
Externally publishedYes

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Genome-Wide Association Study
Crohn Disease
Single Nucleotide Polymorphism
Genes
Ileal Diseases
Colonic Diseases
Pediatrics
Gastroenterology
Canada
Population

ASJC Scopus subject areas

  • Pharmacology (medical)

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Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children. / Amre, D. K.; MacK, D. R.; Morgan, K.; Israel, D.; Deslandres, C.; Seidman, E. G.; Lambrette, P.; Costea, I.; Krupoves, A.; Fegury, H.; Dong, J.; Grimard, G.; Levy, E.

In: Alimentary Pharmacology and Therapeutics, Vol. 31, No. 11, 06.2010, p. 1186-1191.

Research output: Contribution to journalArticle

Amre, DK, MacK, DR, Morgan, K, Israel, D, Deslandres, C, Seidman, EG, Lambrette, P, Costea, I, Krupoves, A, Fegury, H, Dong, J, Grimard, G & Levy, E 2010, 'Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children', Alimentary Pharmacology and Therapeutics, vol. 31, no. 11, pp. 1186-1191. https://doi.org/10.1111/j.1365-2036.2010.04294.x
Amre, D. K. ; MacK, D. R. ; Morgan, K. ; Israel, D. ; Deslandres, C. ; Seidman, E. G. ; Lambrette, P. ; Costea, I. ; Krupoves, A. ; Fegury, H. ; Dong, J. ; Grimard, G. ; Levy, E. / Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children. In: Alimentary Pharmacology and Therapeutics. 2010 ; Vol. 31, No. 11. pp. 1186-1191.
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abstract = "Background Recent genome-wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn's disease (CD). Aims To investigate whether reported genes/loci were also associated with CD in Canadian children. Design and Methods A case-control design was implemented at three paediatric gastroenterology clinics in Canada. Children ≤18 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in five genome-wide association studies reported genes/loci were genotyped. Associations between individual SNPs and CD were examined. Results A total of 406 cases and 415 controls were studied. The mean (±s.d.) age of the cases was 12.3 (±3.2) years. Most cases were male (56.6{\%}), had ileo-colonic disease (L3 ± L4, 52.0{\%}) and inflammatory behaviour (B1 ± p, 86.9{\%}) at diagnosis. Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01). Associations with SNP rs4613763 in the PTGER4 locus were marginally nonsignificant (P = 0.07). The ZNF365 and STAT3 SNPs were predominantly associated with ileal disease with or without colonic involvement. Conclusion The identified susceptibility genes/loci for adult-onset CD also confer risk for paediatric-onset CD.",
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T1 - Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children

AU - Amre, D. K.

AU - MacK, D. R.

AU - Morgan, K.

AU - Israel, D.

AU - Deslandres, C.

AU - Seidman, E. G.

AU - Lambrette, P.

AU - Costea, I.

AU - Krupoves, A.

AU - Fegury, H.

AU - Dong, J.

AU - Grimard, G.

AU - Levy, E.

PY - 2010/6

Y1 - 2010/6

N2 - Background Recent genome-wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn's disease (CD). Aims To investigate whether reported genes/loci were also associated with CD in Canadian children. Design and Methods A case-control design was implemented at three paediatric gastroenterology clinics in Canada. Children ≤18 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in five genome-wide association studies reported genes/loci were genotyped. Associations between individual SNPs and CD were examined. Results A total of 406 cases and 415 controls were studied. The mean (±s.d.) age of the cases was 12.3 (±3.2) years. Most cases were male (56.6%), had ileo-colonic disease (L3 ± L4, 52.0%) and inflammatory behaviour (B1 ± p, 86.9%) at diagnosis. Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01). Associations with SNP rs4613763 in the PTGER4 locus were marginally nonsignificant (P = 0.07). The ZNF365 and STAT3 SNPs were predominantly associated with ileal disease with or without colonic involvement. Conclusion The identified susceptibility genes/loci for adult-onset CD also confer risk for paediatric-onset CD.

AB - Background Recent genome-wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn's disease (CD). Aims To investigate whether reported genes/loci were also associated with CD in Canadian children. Design and Methods A case-control design was implemented at three paediatric gastroenterology clinics in Canada. Children ≤18 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in five genome-wide association studies reported genes/loci were genotyped. Associations between individual SNPs and CD were examined. Results A total of 406 cases and 415 controls were studied. The mean (±s.d.) age of the cases was 12.3 (±3.2) years. Most cases were male (56.6%), had ileo-colonic disease (L3 ± L4, 52.0%) and inflammatory behaviour (B1 ± p, 86.9%) at diagnosis. Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01). Associations with SNP rs4613763 in the PTGER4 locus were marginally nonsignificant (P = 0.07). The ZNF365 and STAT3 SNPs were predominantly associated with ileal disease with or without colonic involvement. Conclusion The identified susceptibility genes/loci for adult-onset CD also confer risk for paediatric-onset CD.

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