Surviving Telomere Attrition with the MiDAS Touch

Rachel L. Flynn, Christopher M Heaphy

Research output: Contribution to journalShort survey

Abstract

Cancer cells maintain telomere lengths through telomerase activity or by alternative lengthening of telomeres (ALT). Using an engineered model system, a recent study by Min et al. reveals that the combination of BLM-mediated DNA resection and telomere clustering, a characteristic of ALT telomeres, catalyzes RAD52-dependent mitotic DNA synthesis (MiDAS) specifically at telomeres to drive ALT activity.

Original languageEnglish (US)
JournalTrends in Genetics
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Telomere Homeostasis
Telomere
Touch
DNA
Telomerase
Cluster Analysis
Neoplasms

Keywords

  • alternative lengthening of telomeres
  • BLM
  • mitotic DNA synthesis
  • RAD52
  • SUMO

ASJC Scopus subject areas

  • Genetics

Cite this

Surviving Telomere Attrition with the MiDAS Touch. / Flynn, Rachel L.; Heaphy, Christopher M.

In: Trends in Genetics, 01.01.2019.

Research output: Contribution to journalShort survey

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