Supervivencia en pacientes con tuberculosis infectados por VIH. Estudio de los fallecimientos en los primeros nueve meses de tratamiento

Translated title of the contribution: Survival in patients with tuberculosis infected with HIV. Study of the deaths within the first nine months

Meritxell Falqués Casanovas, Klaus Langohr, Guadalupe Gómez Melis, Patricia Garcia De Olalla Rizo, Josep M. Jansà López Del Vallado, Joan A. Caylà Buqueras

Research output: Contribution to journalArticle

Abstract

Background: Among the individuals with tuberculosis who are infected with HIV a high degree of lethality has been found to exist during the first few weeks following the start of tuberculosis treatment. In this study, the survival of these individuals is studied within the framework of a retrospective cohort study. Methods: This study included 1135 subjects infected by HIV over age fifteen and residents of Barcelona who were registered by the Barcelona Tuberculosis Prevention and Control Program and were diagnoses within the 1988-1993 period. The variables analyzed were age, gender, former imprisonment, municipal district, risk group, percentage of T CD4+ lymphocytes, tuberculin test, AIDS diagnosis (as per CDC-1987), X-ray pattern, bacteriology and part of the body affected by the tuberculosis. The Cox semiparametric method, the Kaplan-Meir curves and the log-rank test were employed. Results: A 77% probability of survival during the first nine months was found to exist, with wide-ranging variations among the different subgroups. The only significant variables in the Cos multivariate model were AIDS, the percentage oft CD4+ lymphocytes and their interaction. The risk of death for an individual not having AIDS and a T CD4+ lymphocyte percentage of 14% or lower was 7.69 times higher than the risk of dying for an individual not having AIDS who had a T CD4+ lymphocyte percentage of above 14%. Conclusions: The survival of those individuals having tuberculosis who are infected with HIV varies greatly. Those who died in the short term were diagnosed as having AIDS on starting the tuberculosis treatment and who also had a T CD4+ lymphocyte percentage of 14% or lower.

Original languageSpanish
Pages (from-to)549-562
Number of pages14
JournalRevista Espanola de Salud Publica
Volume73
Issue number5
StatePublished - Sep 1 1999

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Keywords

  • AIDS
  • CD4
  • Survival
  • Tuberculin test
  • Tuberculosis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Falqués Casanovas, M., Langohr, K., Gómez Melis, G., Garcia De Olalla Rizo, P., Jansà López Del Vallado, J. M., & Caylà Buqueras, J. A. (1999). Supervivencia en pacientes con tuberculosis infectados por VIH. Estudio de los fallecimientos en los primeros nueve meses de tratamiento. Revista Espanola de Salud Publica, 73(5), 549-562.