Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis

Kalyani Kansal, Manisha Mareddy, Kelly L. Sloane, Alexa A. Minc, Peter V. Rabins, John B. McGready, Chiadi U. Onyike

Research output: Contribution to journalReview article

Abstract

Background: Survival in frontotemporal dementia (FTD) is not well understood. We conducted a mixed effects meta-analysis of survival in FTD to examine phenotype differences and contributory factors. Methods: The PubMed, Medline, EMBASE, CINAHL, PsycINFO and Cochrane databases were searched for studies describing survival or natural history of behavioral variant FTD (bvFTD), progressive non-fluent aphasia (PNFA), semantic dementia (SD), FTD with amyotrophic lateral sclerosis (FTD-ALS), progressive supranuclear palsy and corticobasal degeneration. There were no language restrictions. Results: We included 27 studies (2,462 subjects). Aggregate mean and median survival were derived for each phenotype and, for comparison, Alzheimer's disease (AD) (using data from the selected studies). Survival was shortest in FTD-ALS (2.5 years). Mean survival was longest in bvFTD and PNFA (8 years) and median survival in SD (12 years). AD was comparable in survival to all except FTD-ALS. Age and sex did not affect survival; the education effect was equivocal. Heterogeneity in FTD survival was largely, but not wholly, explained by phenotypes. Conclusions: Survival differs for FTD phenotypes but, except for FTD-ALS, compares well to AD survival. Elucidating the potential causes of within-phenotype heterogeneity in survival (such as complicating features and comorbidities) may open up opportunities for tailored interventions.

Original languageEnglish (US)
Pages (from-to)109-122
Number of pages14
JournalDementia and Geriatric Cognitive Disorders
Volume41
Issue number1-2
DOIs
StatePublished - Mar 1 2016

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Keywords

  • Corticobasal degeneration
  • Epidemiology
  • Frontotemporal dementia
  • Life expectancy
  • Progressive non-fluent aphasia
  • Progressive supranuclear palsy
  • Semantic dementia
  • Survival
  • Years of life lost

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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