TY - JOUR
T1 - Survival in acute myocardial infarction induced by coronary ligation
T2 - Prognostic relevance of certain hemostatic factors during the occlusion phase
AU - Serebruany, Victor L.
AU - Solomon, Scott R.
AU - Shustov, Andrew R.
AU - Herzog, William R.
AU - Gurbel, Paul A.
N1 - Funding Information:
The authors thank Shane Lewis for measuring fibrin fiber thickness in scanning electron micrographs. This work was supported by grants HL123912 (A.A.H. and J.W.W.), HL116916, HL142122, and HL139448 (D.B.C.), from the National Institutes of Health, National Heart, Lung, and Blood Institute; by grant 930/ 04 from the Israeli Science Foundation; and by the Program for Competitive Growth at Kazan Federal University.
Funding Information:
This work was supported by grants HL123912 (A.A.H. and J.W.W.), HL116916, HL142122, and HL139448 (D.B.C.), from the National Institutes of Health, National Heart, Lung, and Blood Institute; by grant 930/ 04 from the Israeli Science Foundation; and by the Program for Competitive Growth at Kazan Federal University.
PY - 1998
Y1 - 1998
N2 - Alterations in various hemostatic factors have been identified as risk factors for survival after acute myocardial infarction (AMI). However, these clinical data are primarily limited to observations made during the postinfarct stage. We assessed the effects of 50 minutes of left anterior descending artery occlusion on several hemostatic factors and analyzed their changes with outcome in 18 Yorkshire swine. Blood samples were obtained from the systemic circulation at baseline and at 25 and 50 minutes of occlusion. Platelet aggregability and plasma antithrombin-III, protein C, protein S, fibronectin, endothelin-1, as well as the metabolites of thromboxane and prostacyclin were measured. Of the 18 swine, 7 survived the infarct and 11 animals developed fatal ventricular fibrillation. Both groups demonstrated significant decreases in platelet aggregation, and a decline in plasma protein S when compared with baseline. Thromboxane, prostacyclin, and endothelin-1 plasma concentrations were also markedly reduced at the end of occlusion. There were significant changes in antithrombin-III, protein C, and fibronectin levels between surviving animals and those that died of ventricular fibrillation. Acute coronary artery occlusion is associated with substantial changes in the hemostatic factors in swine. Plasma levels of fibronectin, antithrombin-III, and protein C differed between survivors and nonsurvivors and thus might serve as predictors of mortality due to fatal ventricular fibrillation during AMI. The mechanisms of these changes during the acute phase of AMI are unclear. Immediate AMI prognosis may be related to hemostatic changes not only after thrombolysis or spontaneous reperfusion, but also during the occlusion phase as well.
AB - Alterations in various hemostatic factors have been identified as risk factors for survival after acute myocardial infarction (AMI). However, these clinical data are primarily limited to observations made during the postinfarct stage. We assessed the effects of 50 minutes of left anterior descending artery occlusion on several hemostatic factors and analyzed their changes with outcome in 18 Yorkshire swine. Blood samples were obtained from the systemic circulation at baseline and at 25 and 50 minutes of occlusion. Platelet aggregability and plasma antithrombin-III, protein C, protein S, fibronectin, endothelin-1, as well as the metabolites of thromboxane and prostacyclin were measured. Of the 18 swine, 7 survived the infarct and 11 animals developed fatal ventricular fibrillation. Both groups demonstrated significant decreases in platelet aggregation, and a decline in plasma protein S when compared with baseline. Thromboxane, prostacyclin, and endothelin-1 plasma concentrations were also markedly reduced at the end of occlusion. There were significant changes in antithrombin-III, protein C, and fibronectin levels between surviving animals and those that died of ventricular fibrillation. Acute coronary artery occlusion is associated with substantial changes in the hemostatic factors in swine. Plasma levels of fibronectin, antithrombin-III, and protein C differed between survivors and nonsurvivors and thus might serve as predictors of mortality due to fatal ventricular fibrillation during AMI. The mechanisms of these changes during the acute phase of AMI are unclear. Immediate AMI prognosis may be related to hemostatic changes not only after thrombolysis or spontaneous reperfusion, but also during the occlusion phase as well.
KW - Animal model
KW - Hemostatis
KW - Myocardial infarction
KW - Prognosis
KW - Ventricular fibrillation
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U2 - 10.1023/A:1008815914024
DO - 10.1023/A:1008815914024
M3 - Article
C2 - 10608047
AN - SCOPUS:0031931332
VL - 5
SP - 29
EP - 35
JO - Journal of Thrombosis and Thrombolysis
JF - Journal of Thrombosis and Thrombolysis
SN - 0929-5305
IS - 1
ER -