Abstract
Background: Despite resistant microbes, induction immunosuppression is used in patients with cystic fibrosis (CF) undergoing lung transplantation (LTx). Methods: To evaluate the effect of induction immunosuppression on survival, the United Network for Organ Sharing (UNOS) was queried restricting analysis to transplant patients 6-55. years old from 2001 to 2012, who received induction agents (INDUCED) or did not (NONE). Results: A total of 1721 CF patients who underwent LTx were included in the analysis; of these 791 (46%) were INDUCED. Of the INDUCED patients, 65% received basiliximab, 10% alemtuzumab, and 25% thymoglobulin/anti-lymphocyte globulin/anti-thymocyte globulin. Mean age was 28.0. years (SD. = 9.7) and 28.5 (SD. = 9.5) for the INDUCED and NONE groups, respectively. The median survival in the INDUCED group was 93.8. months (95% CI: 73.8, --) compared to 61.8. months (95% CI: 55.8-73.8) for the NONE group (log rank p-value <. 0.001). Conclusions: Antibody-based induction immunosuppression had a survival benefit in CF patients undergoing LTx.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 104-110 |
| Number of pages | 7 |
| Journal | Journal of Cystic Fibrosis |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2015 |
Keywords
- Cystic fibrosis
- Immunosuppression
- Induction
- Lung transplantation
- Survival
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pulmonary and Respiratory Medicine