Survival and prognostic factors in hypertrophic cardiomyopathy

A meta-Analysis

Qun Liu, Diandian Li, Alan E. Berger, Roger A Johns, Li Gao

Research output: Contribution to journalArticle

Abstract

Hypertrophic cardiomyopathy (HCM) is a clinically and genetically heterogeneous disorder but data on survival rates are still conflicting and have not so far been quantitatively reviewed. The aim of this study is to conduct a meta-Analysis of cohort studies to assess pooled survival rates and prognostic factors for survival in patients with HCM. Nineteen studies were included representing 12,146 HCM patients. The pooled 1-, 3-, 5-And 10-year survival rates were 98.0%, 94.3%, 82.2% and 75.0%, respectively. Among patients with HCM, age, NYHA functional class, family history of sudden death (FHSD), syncope, atrial fibrillation, non-sustained ventricular tachycardia (nsVT), maximum left ventricular wall thickness and obstruction were significant prognostic factors for cardiovascular death. For sudden cardiac death, FHSD, nsVT, and obstruction showed significant predictive values. Moreover, estimation of population attributable risk (PAR) suggested that nsVT was the strongest predictor for cardiovascular death (13.02%, 95% CI 3.60-25.91%), while left ventricular outflow tract obstruction/mid-ventricular obstruction (LVO/MVO) was the strongest predictor for all-cause death and sudden cardiac death (10.09%, 95% CI 4.72-20.42% and 16.44%, 95% CI 7.45-31.55%, respectively). These risk factors may thus be useful for identifying HCM patients who might benefit from early diagnosis and therapeutic interventions.

Original languageEnglish (US)
Article number11957
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Hypertrophic Cardiomyopathy
Meta-Analysis
Ventricular Tachycardia
Survival
Survival Rate
Sudden Cardiac Death
Sudden Death
Ventricular Outflow Obstruction
Syncope
Atrial Fibrillation
Early Diagnosis
Cause of Death
Cohort Studies
Population

ASJC Scopus subject areas

  • General

Cite this

Survival and prognostic factors in hypertrophic cardiomyopathy : A meta-Analysis. / Liu, Qun; Li, Diandian; Berger, Alan E.; Johns, Roger A; Gao, Li.

In: Scientific Reports, Vol. 7, No. 1, 11957, 01.12.2017.

Research output: Contribution to journalArticle

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abstract = "Hypertrophic cardiomyopathy (HCM) is a clinically and genetically heterogeneous disorder but data on survival rates are still conflicting and have not so far been quantitatively reviewed. The aim of this study is to conduct a meta-Analysis of cohort studies to assess pooled survival rates and prognostic factors for survival in patients with HCM. Nineteen studies were included representing 12,146 HCM patients. The pooled 1-, 3-, 5-And 10-year survival rates were 98.0{\%}, 94.3{\%}, 82.2{\%} and 75.0{\%}, respectively. Among patients with HCM, age, NYHA functional class, family history of sudden death (FHSD), syncope, atrial fibrillation, non-sustained ventricular tachycardia (nsVT), maximum left ventricular wall thickness and obstruction were significant prognostic factors for cardiovascular death. For sudden cardiac death, FHSD, nsVT, and obstruction showed significant predictive values. Moreover, estimation of population attributable risk (PAR) suggested that nsVT was the strongest predictor for cardiovascular death (13.02{\%}, 95{\%} CI 3.60-25.91{\%}), while left ventricular outflow tract obstruction/mid-ventricular obstruction (LVO/MVO) was the strongest predictor for all-cause death and sudden cardiac death (10.09{\%}, 95{\%} CI 4.72-20.42{\%} and 16.44{\%}, 95{\%} CI 7.45-31.55{\%}, respectively). These risk factors may thus be useful for identifying HCM patients who might benefit from early diagnosis and therapeutic interventions.",
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