Abstract
Objective: Our objective was to provide information on survival and disease progression in human immunodeficiency virus antibody-positive pregnant women undergoing prospective evaluation. Study design: After an index delivery, 103 human immunodeficiency virus antibody-positive pregnant women were identified and underwent follow-up for 3 years. The patients were assessed medically and/or gynecologically when hospitalized for a human immunodeficiency virus-related illness or at each follow-up visit. The life-table method was used to estimate the cumulative probabilities of survival and remaining free of acquired immunodeficiency syndrome. Cox's proportional-hazards analyses were used to identify prognostic factors for survival and progression to acquired immunodeficiency syndrome. Results: The majority of human immunodeficiency virus-infected pregnant women were alive 3 years later. Lymphadenopathy syndrome or herpes genitalis was significantly associated with a subsequent diagnosis of acquired immunodeficiency syndrome. Of the 103 original patients, six had acquired immunodeficiency syndrome at the index delivery and acquired immunodeficiency syndrome developed in 24. Approximately 94% of evaluable patients with development of acquired immunodeficiency syndrome had CD4-lymphocyte counts <200/mm3. The most common opportunistic infection was Pneumocystis carinii pneumonia. Acquired immunodeficiency syndrome and postpartum zidovudine therapy were independent prognostic factors affecting survival. Conclusion: Survival was affected by Centers for Disease Control group status of human immunodeficiency virus infection at the index delivery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 152-157 |
| Number of pages | 6 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 167 |
| Issue number | 1 |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- acquired immunodeficiency syndrome (AIDS) in pregnancy, survival of human immunodeficiency virus (HIV)-infected women
- Cox's model
- time-dependent covariates
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
Survival and disease progression in human immunodeficiency virus-infected women after an index delivery. / Gloeb, D. J.; Lai, Shenghan; Efantis, J.; O'Sullivan, M. J.
In: American Journal of Obstetrics and Gynecology, Vol. 167, No. 1, 1992, p. 152-157.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Survival and disease progression in human immunodeficiency virus-infected women after an index delivery
AU - Gloeb, D. J.
AU - Lai, Shenghan
AU - Efantis, J.
AU - O'Sullivan, M. J.
PY - 1992
Y1 - 1992
N2 - Objective: Our objective was to provide information on survival and disease progression in human immunodeficiency virus antibody-positive pregnant women undergoing prospective evaluation. Study design: After an index delivery, 103 human immunodeficiency virus antibody-positive pregnant women were identified and underwent follow-up for 3 years. The patients were assessed medically and/or gynecologically when hospitalized for a human immunodeficiency virus-related illness or at each follow-up visit. The life-table method was used to estimate the cumulative probabilities of survival and remaining free of acquired immunodeficiency syndrome. Cox's proportional-hazards analyses were used to identify prognostic factors for survival and progression to acquired immunodeficiency syndrome. Results: The majority of human immunodeficiency virus-infected pregnant women were alive 3 years later. Lymphadenopathy syndrome or herpes genitalis was significantly associated with a subsequent diagnosis of acquired immunodeficiency syndrome. Of the 103 original patients, six had acquired immunodeficiency syndrome at the index delivery and acquired immunodeficiency syndrome developed in 24. Approximately 94% of evaluable patients with development of acquired immunodeficiency syndrome had CD4-lymphocyte counts <200/mm3. The most common opportunistic infection was Pneumocystis carinii pneumonia. Acquired immunodeficiency syndrome and postpartum zidovudine therapy were independent prognostic factors affecting survival. Conclusion: Survival was affected by Centers for Disease Control group status of human immunodeficiency virus infection at the index delivery.
AB - Objective: Our objective was to provide information on survival and disease progression in human immunodeficiency virus antibody-positive pregnant women undergoing prospective evaluation. Study design: After an index delivery, 103 human immunodeficiency virus antibody-positive pregnant women were identified and underwent follow-up for 3 years. The patients were assessed medically and/or gynecologically when hospitalized for a human immunodeficiency virus-related illness or at each follow-up visit. The life-table method was used to estimate the cumulative probabilities of survival and remaining free of acquired immunodeficiency syndrome. Cox's proportional-hazards analyses were used to identify prognostic factors for survival and progression to acquired immunodeficiency syndrome. Results: The majority of human immunodeficiency virus-infected pregnant women were alive 3 years later. Lymphadenopathy syndrome or herpes genitalis was significantly associated with a subsequent diagnosis of acquired immunodeficiency syndrome. Of the 103 original patients, six had acquired immunodeficiency syndrome at the index delivery and acquired immunodeficiency syndrome developed in 24. Approximately 94% of evaluable patients with development of acquired immunodeficiency syndrome had CD4-lymphocyte counts <200/mm3. The most common opportunistic infection was Pneumocystis carinii pneumonia. Acquired immunodeficiency syndrome and postpartum zidovudine therapy were independent prognostic factors affecting survival. Conclusion: Survival was affected by Centers for Disease Control group status of human immunodeficiency virus infection at the index delivery.
KW - acquired immunodeficiency syndrome (AIDS) in pregnancy, survival of human immunodeficiency virus (HIV)-infected women
KW - Cox's model
KW - time-dependent covariates
UR - http://www.scopus.com/inward/record.url?scp=0026637537&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026637537&partnerID=8YFLogxK
M3 - Article
C2 - 1359787
AN - SCOPUS:0026637537
VL - 167
SP - 152
EP - 157
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 1
ER -