Survival after pancreaticoduodenectomy for periampullary adenocarcinoma: An update

R. C I Van Geenen, T. M. Van Gulik, G. J A Offerhaus, L. Th De Wit, O. R C Busch, H. Obertop, D. J. Gouma

Research output: Contribution to journalArticle

Abstract

Aim: Survival after pancreaticoduodenectomy for periampullary tumours is limited. Over the last decade perioperative management has improved and morbidity and mortality decreased. The aim of the study was to analyse recent survival data after pancreaticoduodenectomy and to determine factors that influence survival. Methods: From October 1992 to September 1998, 204 patients with a ductal adenocarcinoma in the pancreatic head (108), distal bile duct (32), and ampulla (64) who underwent standard pancreaticoduodenectomy, were analysed with regard to histology and tumour status. Survival was calculated by using the Kaplan-Meier method. Risk factors were identified in a univariate and multivariate analysis. Results: Median survival after resection for carcinoma of the pancreatic head, distal bile duct, and ampulla were 16*, 25 and 24* months, respectively (*P=0.008). In the univariate analysis vein resection, blood transfusion of more than four packed red cells, the presence of tumour positive resection margins, lymph-node metastases and poor tumour differentiation significantly decreased survival. In the multivariate analysis positive resection margins, lymph-node metastases, and poor tumour differentiation independently influenced survival. Conclusions: Resection margins, lymph-node status and tumour differentiation are independent prognostic factors. Survival after standard pancreaticoduodenectomy for periampullary tumours has not improved.

Original languageEnglish (US)
Pages (from-to)549-557
Number of pages9
JournalEuropean Journal of Surgical Oncology
Volume27
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Ampullary neoplasm
  • Pancreatic neoplasma
  • Pancreaticoduodenectomy
  • Risk factors
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Surgery

Fingerprint Dive into the research topics of 'Survival after pancreaticoduodenectomy for periampullary adenocarcinoma: An update'. Together they form a unique fingerprint.

  • Cite this

    Van Geenen, R. C. I., Van Gulik, T. M., Offerhaus, G. J. A., De Wit, L. T., Busch, O. R. C., Obertop, H., & Gouma, D. J. (2001). Survival after pancreaticoduodenectomy for periampullary adenocarcinoma: An update. European Journal of Surgical Oncology, 27(6), 549-557. https://doi.org/10.1053/ejso.2001.1162