Survey of the phenotypes of susceptibility to β-lactams in enterobacteriaceae at the pitie-salpetriere hospital

V. Jarlier, R. Bismuth, M. H. Nicolas, J. Nguyen, C. Truffot, J. Grosset

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Abstract

The phenotypes of susceptibility to ampicillin, carbenicillin, cephalothin, cefamandole, cefoxitin and cefotaxime were determined by the disc-diffusion method in 10,994 Enterobacteriaceae consecutively isolated from in-patients during 18 months. The susceptible phenotypes were much more frequent among Escherichia coli, Proteus mirabilis and Klebsiella (67.4 to 84.8%) than among Serratia, Enterobacter and Citrobacter (8.8 to 35.5%). In all species the most common resistance phenotypes were to ampicillin and carbenicillin: E. coli (28%), Pr. mirabilis (15.2%), Klebsiella (23.8%), indole-positive Proteus (33.3%), Serratia (74.4%), Enterobacter (61.4%) and Citrobacter (74.8%). Among E. coli, 4.6% of the strains were resistant to ampicillin and cephalothin but susceptible to carbenicillin. Among E. coli Pr. mirabilis and Klebsiella the strains susceptible only to cefotaxime represented 0.3 to 5% and no cefotaxime-resistant strain was isolated; whereas among Serratia, Enterobacter and Citrobacter the former represented 28.3 to 58.3% and the latter 7.5 to 18.5%. Some important differences in the distribution of the phenotypes according to the type of ward were observed.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Volume14
Issue numberSUPPL. B
StatePublished - Dec 1 1984

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ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Jarlier, V., Bismuth, R., Nicolas, M. H., Nguyen, J., Truffot, C., & Grosset, J. (1984). Survey of the phenotypes of susceptibility to β-lactams in enterobacteriaceae at the pitie-salpetriere hospital. Journal of Antimicrobial Chemotherapy, 14(SUPPL. B), 59-65.